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Studies on the Inhibitory Effect of Blood Transfusion Against Anti-Tumor Immunity

Research Project

Project/Area Number 01480312
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

KODAMA Masashi  Shiga University of Medical Science, Professor, 医学部, 教授 (50079836)

Co-Investigator(Kenkyū-buntansha) SANO Haruo  Shiga Univirsity of Medical Science, Medical Staff, 医学部, 医員
TERADA Nobukuni  Shiga Univirsity of Medical Science, Lecturer, 医学部, 講師 (50167756)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1990: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1989: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsBlood transfusion / Immunological suppression / CTL / NK / TNP-CTL / Suppressor cell / 輸血 / 成分輸血 / TNPーKiller / suppressor cell / JNPーKiller / TNP-Killer
Research Abstract

To analyze the mechanism on the effect of blood transfusion, we studied on survival rate in mice in vivo experiments. Mice that received allogenic blood had significantly worse survival rate than either syngenic-transfuued or saline-infused control groups (C57BL/10 : p<0.05, BALB/C : p<0.01). A transfusion of lymphocytes reduced survival rate in comparison with a transfusion of plasma or RBC (P<0.05). On the other hand, in vitro experiments, the responses of the greop transfused with allogenic donors were significantly lower than responses of control or syngenic transfused group, in either anti-X5563 CTL (P<0.05), TNP-CTL (p<0.01), or NK (p<0.05). Furthermore, we demonstrated that the suppression of CTL activity was mediated by suppressor cells.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 寺田 信國他7名: "担癌宿主の生存率に及ぼす輸血の影響" BIOTHERADY. 3. 1129-1132 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 寺田 信國他2名: "輸血と癌患者の予後" Oncologia. 23. 61-70 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小玉 正智他4名: "輸血による抗腫瘍免疫抑制に関する研究" 病態生理. 9. 579-581 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 土増 聡他2名: "輸血時期を中心とした輸血の抗腫瘍免疫への影響に関する研究" 日本外科学会誌. 93. 1-8 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N. Terata et al.: "The Effect of Blood Transfusion on the Survival of Tumor Bearer" Biotherapy. 3(PART-2). 1129-1132 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N. Terata et al.: "Blood Transfusion and Prognosis of Cancer Patients" Oncolologia. 23. 61-70 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kodama et al.: "Suppression of anti-tumor immunity by allogenic blood transfusion" Medicina Philosophica. 9(7). 579-581 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Domasu et al.: "The Effect of Blood Transfusion on Immunological Response in Mice" J. Japan Surg. Society. 93(1). 1-8 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 寺田 信國 他7名: "担癌宿主の生存率に及ぼす輸血の影響" BIOTHERADY. 3. 1129-1132 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 寺田 信國 他2名: "輸血と癌患者の予後" Oncologia. 23. 61-70 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小玉 正智 他4名: "輸血による抗腫瘍免疫抑制に関する研究" 病態生理. 9. 579-581 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 土増 聡 他2名: "輸血時期を中心とした輸血の抗腫瘍免疫への影響に関する研究" 日本外科学会誌. 93. 1-8 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 寺田 信國,他: "担癌宿主の生存率に及ぼす輸血の影響" BIOTHERAPY. 3. 1129-1132 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小玉 正智,他: "輸血による抗腫瘍免疫抑制に関する研究" 病態生理. 9. 579-581 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 寺田 信國,他: "輸血と癌患者の予後" Oncologia. 23. 61-70 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 寺田信国他7名: "担癌宿主の生存率に及ぼす輸血の影響" BIOTHERAPY. 3. 1129-1132 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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