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Study of orthotopic and auxiliary partial liver grafting from living donor

Research Project

Project/Area Number 01480314
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHiroshima University

Principal Investigator

DOHI Kiyohiko  Hiroshima Univ. School of Med. /Professor, 医学部, 教授 (90034024)

Co-Investigator(Kenkyū-buntansha) ASAHARA Toshimasa  Hiroshiama Univ. School of Med. /Research Professor, 医学部, 助手 (70175850)
FUKUDA Yasuhiko  Hiroshiama Univ. School of Med. /Assistant Professor, 医学部, 講師 (40093801)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsPartial liver grafting / Auxiliary liver grafting / 異所性肝移植部分肝移植 / 同所性部分肝移植
Research Abstract

1) Establishment of auxiliary partial liver grafting procedure after isolating the whole liver of a young pig, left internal and external lobes were separated by bench surgery, and the left lobe was heterotopically grafted in the lower part of the recipient's liver, leaving the latter, as it was. Anastomosis of the graft hepatic vein with the recipient's IVC, porto-portal anastomosis by oblique graft portal vein and through blood flow blockage around the recipient hepatic hilum enable us to make the grafted liver functional No stable results have been obtained yet, but we have some cases of not less than 5-week survival.
2) Establishment of orthotopic partial liver grafing procedure
Left lobe (left internal lobe, external lobe) of a young pig was orthotopically grafted in the recipient, of which the whole liver was isolated. Harvest of a partial liver from the donor and isolation of the recipient's whole liver require considerable amount of skill, but orthotopic partial liver grafting fr … More om the donor in pigs obtained not less than 5-day survival. Moreover, these grafted livers were confirmed to show regenerative hypermat rophy and good function.
3) Examination of the graft size for partial liver grafting and immunological reaction
With the view of examining the size of graft liver necessary for the recipient, the size and the regeneration of the graft liver were examined, using rat orthotopic partiall liver grafting showed approximately similar survival rate to total liver grafting and had grafted liver weight recovered to its original weight 5 days postoperatively. Histologically, hepatocytic karyokinesis was noted frequently 2 days postoperatively, but rarely 5 days postoperatively. On the contrary, isogeneic 20%-partial liver grafting showed not only enhanced postoperative hepatic dysfunction and remarkably lowered survival rate, but also lowered hepatic ATP resynthesis and higher endo-toxihemia compared with the former grafting. The above results indicated that partial liver grafting>30% at least was successful in keeping the recipients life. Examination of iunosuppressants in rat's 30% partial liver grafting model suggested FK506 to be less responsible for hepatic dysfunction than CyA. Less

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 古屋敷 進: "移植肝のviabilityの判定における胆汁流量の有用性について" 日消外会誌. 25(2). 479 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 丸林 誠二: "異所性部分肝移植の実験的研究" 日消外会誌. 25(2). 480 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松坂 知恒: "豚異所性部分肝移植における移植肝のviabilityに関する研究" 移植. 25. 160 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 土肥 雪彦: "生体部分肝移植の諸問題ー特に肝保存とグラフト機能不全についてー" 移植. 26. 171 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 厚雄: "ラット同所性部分肝移植の研究" 移植. 26. 341 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 丸林 誠二: "部分肝移植の実験的研究" 移植. 26. 342 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 板本 敏行: "移植" In situ肝冷却潅流に関する実験的検討, 351 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsusaka. C.: "Stydy of examining the viability for grafting liver in auxiliary partial liver transplant in pig" Jap. J. Transplant.25. 160 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Dohi. K.: "Problem of partial liver transplant from living donor-preservation and graft non-functioning" Jap. J. Transplant.26. 171 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kimura. A.: "Study of orthotopic partial liver transplant" Jap. J. Transplant.26. 341 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Marubayashi. S.: "Experimental study for partial liver transplant" Jap. J. Transplant.26. 342 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Itamoto. T.: "Experimental study of in situ cooling perfusion for the liver" Jap. J. Transplant.26. 351 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Marubayashi. S.: "Experimental study for auxiliary partial liver transplant" Jap. J. Gastroenterol. Surg.25(2). 480 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fwruyashiki. S.: "Bile flow in examining the viability of transplanted liver" Jap. J. Gastroenterol. Surg.25(2). 479 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 古屋敷 進: "移植肝のviabilityの判定における胆汁流量の有用性について" 日消外会誌. 25(2). 479 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 丸林 誠二: "異所性部分肝移植の実験的研究" 日消外会誌. 25(2). 480 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松坂 知亘: "豚異所性部分肝移植における移植肝のviabilityに関する研究" 移植. 25. 160 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 土肥 雪彦: "生体部分肝移植の諸問題ー特に肝保存とグラフト機能不全についてー" 移植. 26. 171 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 厚雄: "ラット同所性部分肝移植の研究" 移植. 26. 341 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 丸林 誠二: "部分肝移植の実験的研究" 移植. 26. 342 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 板本 敏行: "移植" In situ肝冷却潅流に関する実験的検討, 351 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 春日直樹: "バイオポンプを用いた同所性豚肝移植の研究" 移植. 23. 162 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 小野栄治: "ブタ同所性肝移植の予後に影響する因子の検討" 移植. 24. 245 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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