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Immunotherapy of lung cancer using biotechnological methods.

Research Project

Project/Area Number 01480338
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

KIMURA Hideki  Chiba Univ., 医学部, 講師 (10161572)

Co-Investigator(Kenkyū-buntansha) YUSA Toshikazu  Chiba Univ., 医学部, 助手 (70230620)
BABA Masayuki  Chiba Univ., 医学部, 助手 (00143305)
SHIBA Mitsutoshi  Chiba Univ., 医学部, 助手 (20162620)
FUJISAWA Takehiko  Chiba Univ., 医学部, 助教授 (80110328)
YAMAGUCHI Yutaka  Chiba Univ., 医学部, 教授 (80009448)
藤野 道夫  千葉大学, 医学部, 医員
山川 久美  千葉大学, 医学部, 助手 (80191211)
門山 周文  千葉大学, 医学部, 助手 (30152763)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsLung Cancer / Immunotherapy / LAK cell / IL-2 / Adjuvant treatment / LAK Cell / Adjuvant療法 / 肺癌 / 免疫療法(AIT) / 集学的治療 / OKT3 / LAK細胞 / IL2 / 細胞障害テスト
Research Abstract

A controlled, randomized study has been conducted to assess the efficacy of adoptive immunotherapy with Interleukin 2(IL2)and lymphokine activated killer cells(LAK cells)combined with chemotherapy or radiotherapy for advanced non-small cell lung cancer(NSCLC)patients. Out of 403 NSCLC patients who received resection of primary tumors from Jan. 1985 to Dec. 1990 in our hospital, a total of 106 patients with relatively curative and non-curative resection, were entered into a randomized controlled trial of postoperative adjuvant immunotherapy. The former group(n=36)was divided into three groups ; a)Chemotherapy(CDDP+VDS)group(n=13), b)Chemoimmunotherapy(CDDP+VDS+IL2+LAK cells)group(n=12), and c)control group(n=ll). The latter(noncurative)group(n=68)was randomized into d)immunotherapy(chemo/radiotherapy+IL2+LAK cells)group(n=33)and e)control(chemo/radiotherapy alone)group(n=35).
The overall 4 year survival rates of immunotherapy(b+d)and control(a+c+e)groups were 52.4% and 28.3% respectively and the difference was significant(p<0.01)with generalized Wilcoxon test. In the relative curative group, the 4 year survival rates of a), b), and c)groups were 34.2%, 70.9% and 34.1% respectively. In the non-curative group, those of d)and e)groups were 43.1% and 29.3%(p<0.05). From this study, it it suggested that adoptive immunotherapy with IL2 and LAK cells is effective as a postoperative adjuvant immunotherapy for advanced NSCLC patients.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Hideki Kimura: "Cytotoxic activity of various LAK cells agairst aitelegeus lung cancer,K-562,and Daudi Cell" Jap.J.Clin.Oncol. 19. 222-228 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 秀樹他: "ILー2,LAK療法の宿主免疫能に対する影響" Biotherapy. 4. 1712-1717 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 秀樹他: "原発性肺癌切除例における非治癒因子の検討" 日本胸部外科会誌. 39. 257-261 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 秀樹他: "ボ-タ-カット皮下埋め込み式カテ-テルによる転移性肝癌" 癌と化学療法. 18. 1561-1574 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Limin Sun,Hideki Kimura他: "Effect of antiーCD3 monochonal antibody on cytotoxic activity of various LAK cells" J.Jap.Soc.Cancer Thera. 26. 2508-2520 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hideki Kimura他: "Establishment of large cell lang cancer cell lines Recreting growth factors act on leukouyte and platelet progenitor cells." Jap.J.Clin.Oncol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山口 豊(共著): "肺癌外科治療の変様と治療成績向上対策の現況(癌治療の変様と展望)" 蟹書房, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi,Hideki Kimura(共著): "Post sungical adjuvant LAK theragy in patients with primary lung cancer(Current advances and perspectives on Cancer treatment)" 北海道大学出版, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hideki Kimura etal.: "Cytetoxic Activity of varicus LAK cels against autologeus lung cancer,Kー562,and Daudi Cell" Jap.J.Clin Oncol. 19. 222-228 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 秀樹 他: "ILー2,LAK療法の宿主免疫能に対する影響" Biotherapy. 4. 1762-1767 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 秀樹 他: "原発性肺癌切除例における非治癒因子の検討" 日本胸部外科会誌. 39. 257-261 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 秀樹 他: "ポ-タ-カット皮下埋め込式カテ-テルによる転移性肝癌に対する抗癌剤LAK動注療法" 癌と化学療法. 18. 1561-1574 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Limin Sun,Hideki Kimura 他: "Effect of antiーCD3 morne clonal antibody on cytotoxic activity of variouo LAK cells" J.Jap.Soc.Cancer Ther.26. 2508-2520 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hideki Kimura: "Establish ment of large cell lung cancer cell lines pecreting growth jactors act on leukocyte and platelt progenitor cells" Jap.J.clin.Oncol.

    • Related Report
      1991 Annual Research Report
  • [Publications] 山口 豊(共著): "肺癌外科療法の変様と治療成積向上対策の現況(癌治療の変様と展望)" 蟹書房, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yutaka,Yamaguchi,Hideki Kimura,etal(共著): "Post surgicae adjuvant LAK thrapy in patients with primary lung cancer(Current advances and perspectives in cancel treatment)" 北海道大学出版, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 秀樹,山口 豊: "ILー2,LAK療法の宿主免疫能に対する影響" Biotherapy. 4. 1762-1767 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山口 豊,木村 秀樹他: "肺癌手術の治療成績とその現況" 臨床外科. 45. 51-55 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 秀樹,山口 豊他: "原発性肺癌非治癒切除例の検討 その1.非治癒因子からみた検討" 日本胸部外科学会誌. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 秀樹,山口 豊他: "原発性肺癌非治癒切除例の検討.その2.年代別にみた治療成績について." 日本胸部外科学会誌. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Limin Sun,H.Kimura,Y.Yamaguchi: "Effect of AntiーC D_3 m Ab or cytotofic Activity of Variouo LAK cells" Japanese,J.Clinical Oncology.

    • Related Report
      1990 Annual Research Report
  • [Publications] 山口 豊,木村 秀樹,藤野 道夫: "リンパ球sourceとLAK活性に関する検討" 病態生理. 10. 155-157 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村秀樹,山口豊: "肺癌に対するIL2,LAK細胞による受動免疫療法" 日本外科学会誌. 90. 1459-1462 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hideki Himura Yutaka Yamaguchi: "Cytotoxic Activity of Various LAK Cells against Auto gous Lung Cancer,K-562,and Daudi Cells." Jpn.J.Clin.Oncol. 19. 222-228 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊 ほか: "肺非小細胞癌に対する術前化学療法の検討" 日本呼吸器外科学会雑誌. 3. 302-307 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山口豊,木村秀樹,馬場雅行,川野裕ほか: "肺癌手術の治療成績とその現況" 臨床外科. 45. 51-55 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊,藤沢武彦,柴光年ほか: "肺癌外科治療の再評価、N_2症例の成績と手術適応" 日胸外会誌. 37. 884-885 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊,柴光年: "肺、気管支生検" 臨床外科. 44. 1029-1034 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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