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The Basic and Clinical Studies of Interstitial Hyperthermia of Brain Tumors using

Research Project

Project/Area Number 01480353
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNagoya University

Principal Investigator

TOHNAI Iwai (1991)  Nagoya University School of Medicine, Assist. Prof., 医学部, 講師 (50172127)

小林 達也 (1989-1990)  名古屋大学, 医学部, 助教授 (10093030)

Co-Investigator(Kenkyū-buntansha) AMEMIYA Toshifumi  Chiba Institute of Technology, Prof., 工学部, 教授 (50023221)
MATSUI Masaaki  Nagoya University School of Technology, Prof., 工学部, 教授 (90013531)
KUTIWAKI Hirozi  Nagoya University School of Medicine. Assist. Prof., 医学部, 講師 (60135340)
藤内 祝  名古屋大学, 医学部, 講師 (50172127)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsImplant heating system / Interstitial hyperthermia / Ferromagnetic implant / Curie temperature / Magnetic induction / Brain tumor / Oral tumor / Heat shock protein / 口腔腫瘍 / ヒ-トショックプロティン / キュ-リ-温度 / 口腔内腫瘍 / 鉄ー白金合金 / 感温磁性体 / 高周波磁場発生装置
Research Abstract

l. Development of Implant Heating System (IHS)
We observed that the Fe-Pt afloy (Fe : 73%i Pt : 27%, -Curie point : 68) is the best implant needle of the Implant Heating System (IHS). And we developed IHS for clinical study. The IHS consists of three parts : implant needle, induction coil and generator. The implant needle is 1.8mm in diameter and 15, 20, 25 mm in length, of which Curie pointa is set at 68. The induction coil is 30 cm in diameter, maximum magnetic field strength at the center of the coil is 16.7 Oe. And the generator. has 2.5 kill of maximum power, yielding the high frequency of 240 kHz.
2. Experimental studies
We have investigated intracellular translocation of hsp-70 during at moderate temperatures in HeLa cells. When cells were heated at temperatures above 41, hsp-70 translocated from the cytoplasm into the nuclei and apparently accumulated in nucleoli within, 10 min. At temperatures above 42, hsp-70 remained in the nuclei during, heating.
Then we studied the histopathol … More ogical changes in rabbit tongue tumor model (VX-7 carcinoma) after single treatment of hyperthermia using IHS. The tumor tissue at 5mm apart from implant needle was showed coagulation necrosis. The necrotic lesion -was irregular shaped and tended to extend gradually toward the peripheral side of the tongue for 3 days.
3. Clinical studies
Safe, repeated and longterm treatment of 25 cases of inoperable, recurrent brain tumors (Glioma : 13cases, Meta. : 7cases, Others : 5cases) have been made by the IHS. Before inducing hyperthermia, one or more implants were placed within the tumor by CT guided stereotaxis or inserted manually at craniotomy depending on the size of tumors. All the cases received repeated hyperthermia, combined with either radiotherapy or chemotherapy. The clinical response were 3 CR, 5 PR, 4 MR, 3 ST and 8 PD.
Thirteen cases (tonque : 7cases, mouth floor : 2cases, gingiva : 2cases, palate : lcase lip : lcase) of oral cancer has been treated by IHS. Three cases were treated by IHS, irradiation and chemotherapy, and three cases were treated by IHS and chemotherapy (CDDP : 200mg, PEP : 70-80mg). The other 7 cases were treated by IHS, chemotherapy and operation. The clinical response were 9 CR and 4 PR. Less

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Kobayashi T,et al: "Interstitial Hyperthermla of Experlmental Brain Tumor using Implant Heating System" J.Neuro-Oncology. 7. 201-208 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 後藤 康之他: "Implant Heating Systemによる口腔悪腫瘍に対する組織内温熱療法" 日本ハイパ-サ-ミア誌. 6. 439-449 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤内 祝他: "舌癌に対するImplant Heating Systemによる組織内温熱療法" 日本ハイパ-サミア誌. 6. 450-461 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木田 義久他: "インプラントヒ-ティングシステムによる脳腫瘍の組織内温熱療法ー病理学的検討ー" 日本ハイパ-サミア誌. 7. 159-169 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hayashi Y,et al: "Translocation of hsp-70 and Protein Synthesis during Continous Heating at Mild Temperature in HeLa Cells" Radiation Research. 125. 80-88 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T,et al: "Interstitial hyperthermia of malignant brain tnmors by im〔lant heating system:Clinical experience" J.Nenro-Oncology. 10. 153-163 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小林 達也: "ハイパ-サ-ミアマニュアル" 松田 忠義(マグブロス出版), 192 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T, et al.: "Interstitial Hyperthermia of Experimental Brain Tumor using Implant Heating system" J. Neuro-Oncology. 7. 201-208 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goto Y, et al: "Interstitial Hyperthermia for Oral Malignant Tumor using Implant Heating System - Experimental Studies on Rabbit Tumor Model -" Jpn. J. Hyperthermic Oncol.6. 439-449 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohnai I, et al: "Interstitial Hyperthermia for Cancer of the Tongne using an Implant Heating System" Jpn. J. Hyperthermic Oncol.6. 450-461 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kida Y, et al: "Hyperthermia of Malignant Brain Tumor with Implant Heating System - Histopathological Study -" Jpn. J. Hyperthermic Oncol.7. 159-169 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hayashi Y, et al: "Translocation of hsp-70 and Protein Synthesis during Continous Heating at Mild Temperature in HeLa cells" Radiation Research. 125. 80-88 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T, et al: "Interstitial hyperthermia of malignant brain tumors by implant heating system : Clinical experience." J. Neuro-Oncology. 10. 153-163 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T: "Hyperthermia Manual" Matsuda T.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤内 祝 他: "頭頚部癌に対する発熱磁性体を用いたImplant Heating systemの効果と適応について" 頭頚部腫瘍. 17. 156-161 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tastuya Kobayashi: "Interstitial hyperthermia of malignant brain tumor by implant heating system:clinical experience" J.NeuroーOncology. 10. 153-163 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yasushi Hayashi: "Translocation of hspー70 and Protein Synthesis during Continuous Heating at Mild Temperatures in HeLa Cells" Radiation Research. 125. 80-88 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 後藤 康之: "口腔悪性腫瘍に対するImplant Heating Systemを用いた組織内温熱療法の実験的研究" 口腔科学会雑誌. 40. 778-788 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小林 達也,他: "インプラントヒ-ティングシステム(IHS)を用いた悪性脳腫瘍の組織内温熱療法" 脳神経外科. 18. 247-252 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小林 達也,他: "脳腫瘍に対する新しい組織内温熱療法" 腫瘍と感染. 3. 207-211 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小林 達也: "脳腫瘍に対する温熱療法と放射線外科" 現代医学. 37. 371-380 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小林 達也,他: "インプラントヒ-ティングシステムを用いた脳腫瘍の組織内温熱療法の効果" 日本ハイパ-サ-シア誌. 6. 149-158 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木田 義久,他: "悪性グリオ-マの組織内温熱療法ーInplant Heating systemによる検討ー" 脳神経外科. 18. 1007-1014 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤内 祝,他: "舌癌に対するInplant heating Systemによる組織内温熱療法" 日本ハイパ-サ-シア誌. 6. 450-461 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tatsuya Kobayashi: "Stereotactic and Funcronal Neurosurgery" Karger AG,Basel, 5 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小林達也: "インプラントヒ-ティングシステム(IHS)を用いた悪性脳腫瘍の組織内温熱療法" 医学のあゆみ. 150. 223-224 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 小林達也: "磁性体を埋め込んで組織内加温-脳腫瘍の新しい温熱療法-" モダンメディシン. 18. 66-69 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tatsuya Kobayashi: "Interstitial Hyperthermia of Experimental Brain Tumor using Implant Heating System." J.Neuro-oncology. 7. 201-208 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takayuki Tanaka: "Effect of combined treatment with magnetic induction hyperthermia and chemotherapy in a rabbit brain tumor model." Neurol.Med-chir.(Tokyo). 29. 377-381 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tatsuya Kobayashi: "Hyperthermic Oncology 1988,Vol.II" Taylor & Francis,London, 4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuyoshi Hattori: "Hyperthermic Oncology 1988,Vol.II" Taylor & Francis,London, 2 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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