| Project/Area Number |
01480386
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SHIMIZU Tetsuya Asahikawa Medical College. Dept. of OB&GYN. Professor, 医学部, 教授 (20000979)
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| Co-Investigator(Kenkyū-buntansha) |
SENGOKU Kazuo Asahikawa Medical College. Dept. of OB&GYN. Instructor, 医学部, 講師 (30163124)
TANAKA Kunio Asahikawa Medical College. Central Laboratory for Research & Education. Associat, 実験実習機器センター, 助教授 (20041840)
ISHIKAWA Mutsuo Asahikawa Medical College. Dept. of OB&GYN. Associate Professor, 医学部, 助教授 (20002131)
木村 広幸 旭川医科大学, 医学部, 助手 (90214890)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | MRI / Magnetic exposure / Gonadotoxity / In vitro fertilization / Ovulation / Embryonic development / Anti-neoplastic agents |
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| Research Abstract |
For safety aspects of NMR clinical imaging, the gonadotoxic effect of NMR clinical imaging procedures and static homogeneous field of 1.5T has been investigated in vivo.
1. In order to establish methods to evaluate gonadotoxity of static magnetic exposure, as control experiment gonadotoxicity of anti-neoplastic agents for female mice has been studied. First, anti-neoplastic agents (Act-D, MTX, VP-16) were injected to female mice which were induced superovulation. There was no detectable decrease in numbers of ovulation soon after chemotherapy. However, the numbers of vulation decreased to 80% ofcontrol on 24 days after chemotherapy. Second, after chemotherapy female mice were mated with male mice in natural ovulation cycle. In the first cycle of ovulation effterchemotherapy, the number of embryos statically decreased as compared to non-exposedcontrols. AT the 3rd cycle of ovulation after chemotherapy, the number of embryos recovered to contrals.
2. Using the static magnetic exposure facility, experiments were perfound, to evaluate on reproductive efficiency and gonadotoxity of the exposure of female mice. There was a slight decrease of number of ovulation in superovulated female mice as compared to control. The effects of embryonic development of exposure to 1.5T of pregnant mice has also been studied from 2nd day to 5th day after mating. The offspring were examined prenatary. There was slight decrease in number of embryos as compared to control. The results of this study suggest that static homogeneous magnetic exposure of female mice causes goandotoxity and reduction of reproductive efficiency.
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