| Project/Area Number |
01480403
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
YAMAGUCHI Nobuo Kanazawa Medical University, Serology, Professor, 血清学教室, 教授 (10106916)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Shoji Kanazawa Mecidal University, Serology, lecturer, 血清学教室, 講師 (30150759)
YAMADA Tsubara Kanazawa Medical university, Pediatrics, Lecturer, 小児科学教室, 講師 (70102035)
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Reproductive immunity / Pregnancy / Infection / Antibody production / Suppression of active immunity / Suppressive cell / 制性細胞 |
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| Research Abstract |
The present study focused on the influence of maternal immunity during pregnancy on the responsiveness of the immune system (s) in the offspring. Maternal immunization of pregnant mice with T-dependent foreign antigen SRBC induced suppression-of anti-SRBC PFC responses in their offspring. We attempted to identify the cell-species among the maternal lymphoid cells of the immunized pregnant mice that induced this suppression in their offspring, by separating the maternal cells into T-, B-cells and macrophages, or T-cell subsets, and then adoptively transferring them into other normal pregnant mice. The results demonstrated that the maternal CD4^+ T-cells of the immunized pregnant mice induced the immune suppression in their offspring and that the maternal T-cells could be activated uniquely during pregnancy. Furthermore, cellular organization was required for the maternal T-cells to induce this immune suppression in their offspring.
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