| Project/Area Number |
01480416
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIOSAKA Sadao Osaka University, Med. Sch., Associate Prof., 医学部, 助教授 (90127233)
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| Co-Investigator(Kenkyū-buntansha) |
KUWAYAMA Yasuaki Osaka University, Med. Sch., Research Assist., 医学部, 助手 (70186568)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | Beta_2-adrenergic receptor / Immunohistochemistry / Retina / Neurotransmission / Calbindin / Dopaminergic amacrine cell / チロシンハイドロキシレ-ゼ / ド-パミン / アドレナ-ジックレセプタ- |
|---|
| Research Abstract |
Using antisera against tyrosine hydroxylase (TH) and purified beta_2-adrenergic receptors (beta_2-AdR), we found that TH- and AdR-like immunoreactivities coexisted in large amacrine cells. These findings indicated an association between dopamine-containing amacrine cells and adrenergic amacrine cells. The present study also showed that amacrine cells with TH-like immunoreactivity have vitaminDdependent calcium-binding protein (calbindin. 27000 kDa)-like immunoreactivity as well, suggesting that calbindin plays an important post-synaptic role in dopaminergic amacrine cells.
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