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The study on De- and Re-mineralization of Cementum in vitro and in vivo.

Research Project

Project/Area Number 01480484
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 小児・社会系歯学
Research InstitutionNagasaki University

Principal Investigator

TAKAGI Okiuji  Nagasaki University, School of Dentistry, Professor of Dentistry., 歯学部, 教授 (80005090)

Co-Investigator(Kenkyū-buntansha) INABA Daisuke  Nagasaki University, School of Dentistry, Research Associate., 歯学部, 助手 (90146085)
川崎 浩二  長崎大学, 歯学部, 助手 (60161303)
飯島 洋一  長崎大学, 歯学部, 助教授 (70094860)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
KeywordsRoot Caries / Cementum / Remineralization / Fluorides / Anti-caries Effect / Microradiography / 再石炭化 / マイクロラジオグラフ / 脱灰
Research Abstract

In our study during 1989-1990, the effects of fluoride (F) content on the remineralization of root surfaces were not clarified because F level of remineralizing solution was fixed at 3.0 ppm. To access the relationship between F level in solution and the degree of remineralization, demineralized root specimens with cementum were immersed in solutions at different F level (0.5, 1, 0, 2, 0 and 3, 0 ppmF : F05, F1, F2, F3 group) for 14 days without application of fluorides. Treatment with F free solution (FO) was also studied. The results were as follows ;
(1) Treatments with F containing solutions were significantly effective with relative mineral increments (against the mineral volume after demineralization), F05 : 6.4%, F1 : 7.6%, F2 : 9.2%, F3 : 10.0% and F3 : 13.9%, respectively. The mineral volume increments were remarkably depended on F level in solution and significant coefficient correlation (r=0.98, p<0.05) was observed.
(2) F contents in surface layer (depth : 0-15mum) after 14-day remineralization were F0 : 1, 700ppm, F05 : 5, 000ppm, F1 : 6, 600ppm, F2 : 7, 200ppm and F3 : 7, 400ppm, respectively. Group F05, F1, F2 and F3 showed significantly higher F contents than F0. Furthermore, F contents in deeper part (depth : 40-50mum) of F2 and F3 were also significantly higher than those of another groups.
Our previous findings in 1989-1990 were presented in the 40th Conference of the Japanese Society for Dental Health (September, 1991), and the main results obtained during 1989-1992 were published as a original paper in Journal of Dental Health (D. INABA : Vol. 42, p. 66-78, 1992).
In addition, we have developed the quantitative video-densitometry for the evaluation of mineral volume, and we now intend to publish the papers on the new methodology and its application.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 稲葉 大輔: "再石灰化エナメル質および歯根表層におけるlaminationの画像解析法による評価" 口腔衛生学会雑誌. 41. 294-300 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 稲葉 大輔: "in vitroにおける根面初期齲蝕の再石灰化とフッ素取り込みにおよぼす各種フッ化物の効果に関する研究" 口腔衛生学会雑誌. 42. 66-78 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Daisuke INABA: "Evaluation of Lamination in Remineralized Enamel and Root Surfaces by Digital Image Processing" J. Dent. Health. 41, No, 3. 294-300 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Daisuke INABA: "In vitro Study on the Effects of Various Fluorides on the Remineralization and Fluoride Incorporation in Early Caries Lesion of Root Surfaces" J. Dent. Health. 42, No. 1. 66-78 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 稲葉 大輔,飯島 洋一,高木 興氏: "再石灰化エナメル質および歯根表層におけるlaminationの画像解析法による評価" 日本口腔衛生学会雑誌. 41. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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