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Molecular and cytogenetic studies on hematopoietic cells in heavily exposed A-bomb survivors

Research Project

Project/Area Number 01480534
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 放射線5生物学
Research InstitutionHiroshima University

Principal Investigator

KAMADA Nanao  Research Institute for Nuclear Medicine & Biology, Hiroshima University, Professor, 原爆放射能医学研究所, 教授 (00034629)

Co-Investigator(Kenkyū-buntansha) TANAKA Kimio  Research Institute for Nuclear Medicine & Biology, Hiroshima University, Researc, 原爆放射能医学研究所, 助手 (70116622)
NIWA Ohtsura  Research Institute for Nuclear Medicine & Biology, Hiroshima University, Profess, 原爆放射能医学研究所, 教授 (80093293)
TOGE Tetsuya  Research Institute for Nuclear Medicine & Biology, Hiroshima University, Profess, 原爆放射能医学研究所, 教授 (40034657)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsAtomic bomb survivor / Chromosome abnormality / RAS oncogene / Acute leukemia / Chronic leukemia / Transforming gene / 近距離被爆者 / 死因調査 / 癌発生率 / 健康調査 / 慢性白血病 / BCR遺伝子 / トラシスフォ-ム遺伝子 / ras遺伝子 / 被爆線量
Research Abstract

I. Studies on heavily exposed A-bomb survivors who have no clinical trouble at present ;
a)Cytogenetic studies revealed 5- 45.6% of chromosome abnormalities in the peripheral lymphocytes, which were. estimated to be 9- 650 rad of exposure at the time of bombing.
b)Serological studies for anti-BAST antibody shown that percent of position cases was significantly higher in the proximally exposed group.
c)Molecular-biological studies revealed the transforming -N-ras and K-ras genes in two and one survivors, respectively.
II. Studies on leukemia patients with a history of exposed to Atomic Bomb Radiation.
a)Cytogenetic study on acute leukemia :
Seventy five radiation--'related leukemia(acute non-lymphocyte)in Hiroshima including 16 patients exposed to more than one Gray were cytogenetically examined. Statistical analysis of the data on the frequencies of chromosomal aberrations in survivors according to the bone marrow doses of DS86 estimation revealed that heavily exposed patients tended to have significantly higher aberration rates as compared, -with non-exposed patients. Furthermore, the chromosomal aberrations in the survivors were-observed to be of a more complex nature and had characteristic findings of secondary leukemia.
b)Molecular biological studies on transforming genes in acute and chronic leukemia and the bcr gene in chronic myelocytic leukemia have been performed in exposed and non-exposed groups. So far, no distinctive differences have been observed in the frequency and the sites of point mutations in N-. and K-ras genes or in the rearrangement of the bcr gene, for a final conclusion of the specificity of radiation induced leukemia.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Tanaka,K.: "9;22 translocation and bcr rearragements in chronic myelocytic patients among atomic bomb survivors" Joural of Radiation Research. 30. 352-358 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada,N.: "Acute and late errects of A-bomb radiation studied in a group of young girls with a defined condition at the time of bombing." Joural of Radiation Research. 30. 218-225 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鎌田 七男: "近距離被爆生存者に関する総合医学的研究 第18報antiーBAST抗体陽性率と被爆距離との関係" 広島医学. 43. 394-395 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 田中 公夫: "原爆被爆者にみられたras遺伝子突然変異" 長崎医会誌. 65. 573-580 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada,N.: "Cytogenetic and molecular changes in leukemia found among atomic bomb survivors" Journal of Radiation Research. 32. 172-179 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada,N.: "Chromosome abnormality in early entrants" Journal of Radiation Research. 32. 275-277 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamaka, N., Shigeta, C., Kuramoto, A., Munaka, M. et al: "Acute and late effects of A-bomb radiation studied in a group of young girls with a defined condition at the time of bombing." Journal of Radiation Research. 30. 218-225 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tanaka, K., Takechi, M., Hong, J. H., Shigeta, C. et al: "9 ; 22 translocation and bcr rearrangements in chronic myelocytic patients among atomic bomb survivors." Journal of Radiation Research. 30. 352-358 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada, N.: "Cytogenetic and molecular changes in leukemia found among atomic bomb survivors." Journal of Radiation Research. 32. 172-179 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada, N.: "Chromosome abnormality in early entrants." Journal of Radiation Research. 32. 275-277 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kamada,N.: "Cytogenetic and molecular changes in leukemia found among atomic bomb survivors" Journal of Radiation Research. 32. 172-179 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kamada,N.: "Chromosome abnormality in early entrants" Journal of Radiation Research. 32. 275-277 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鎌田 七男: "近距離被爆生存者に関する総合医学的研究.第20報過去18年の死亡および疾病状況" 広島医学. 45. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鎌田 七男: "原爆放射の人体への影響" 文光堂, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鎌田 七男: "近距離被爆生存者に関する総合医学的研究 第18報 AntiーBAST抗体陽性率と被爆距離との関係" 広島医学. 43. 394-395 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 久住 静代: "広島における白血病調査:1980〜1987年" 広島医学. 43. 396-398 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐藤 幸男: "原爆被爆者の次世代(F_1)及び次々世代(F_2)にみられた所見の比較検討" 広島医学. 43. 459-465 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 田中 公夫: "低線量カリフォルニウム( ^<252>cf)中性子のヒト造血系細胞染色体に及ぼす影響" 広島医学. 43. 532-535 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小熊 信夫: "広島市における早期入市被爆者の染色体異常" 平成元年度原爆障害調査研究班報告書. 26-29 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤村 欣吾: "被爆者におけるM蛋白血症 第1報 昭和63年度がん検診報告" 広島医学. 43. 406-409 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kamada,N.: "Acute and late effects of A-bomb radiation studied in a group of young girls with a defined condition at the time of bombing" J.Radiat.Res.30. 218-225 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kamada,N.: "Chromosome aberrations in lymphoid malignancies and transforming gene in adult T cell leukemia" Lymphoid Malignancy-Immunocytology and Cytogenetics. 57-66 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shigeta,C.: "Effect of tritiated water on human hemopoietic stem cells" Proceeding of the 3rd Japan-US Workshop P-133 on Tritium Radiobiology and Health Physics. 143-148 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tanaka,K.: "9;22 translocation and bcr rearrangements in chronic myelocytic patients among atomic bomb survivors" J.Radiat.Res.30. 352-358 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 鎌田七男: "原爆後障害研究の歩み" ヒロシマ医師のカルテ. 179-185 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 鎌田七男: "近距離被爆者血清中に正常ヒト胎盤絨毛基底膜と反応する抗体の検出" 昭和63年度原爆障害症調査研究班報告書. 114-116 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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