| Project/Area Number |
01550049
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Aerospace engineering
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| Research Institution | Tokyo Metropolitan Institute of Technology |
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Principal Investigator |
TERAI Minoru Tokyo Metropolitan Institute of Technology, Engineering, Associate Professor, 工学部, 助教授 (10087116)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 武雄 東京都立神経科学総合研究所, 研究員 (30142160)
ITOH Noriko Tokyo Metropolitan Institute of Technology, Engineering, Associate Professor, 工学部, 助教授 (30040116)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | extreme environment / astronouts' bone mass / stress / bone mass loss / decalcification / dephosphate from bone / ATP / epinephrine / リン比 / 緊張 / 極限環境 / 骨中リン酸カルシウム / 生理機能制御 / カテコ-ルアミン / 副腎皮質ホルモン / エネルギ-循環 / β-エンドルフィン |
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| Research Abstract |
In 21 century, Homosapiens will be able to fling away and live anywhere in the space. Though the human's hope might be reached in the final goal., we have many problems to solve before departing for the space. One of the most difficult problems to solve is psychological and physical stress being loaded to astronauts in the space. Generally speaking, astronaut's bone mass loss is caused by microweight or weightlessness in the space. We considered another possibility of decalcification of astronaut's bone in the space. If the astronaut subjects him in any strong psychological and physical stress in his space flight, he consumes so much energy in his body. Now, energy is produced by dephosphate from high energy phosphate compound(ATP)in the human body. If much phosphate is used in the body, phosphate in the body liquid such as blood or/and cell fluid lacks in them. Then phosphate is provided from his bone. We intended to prove relationships between psychological and physical stress and th
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e decalcification of astronaut's bone.
The experiments were carried using Wistar male and female rats for this object. Stress was loaded to rats by means of swimming and running. First group rats were forced to swim until being drowned. Second group rats were run until being tired out. Rats' urine sample was collected at 3 hours before each stress loading, in stress loading and 3 through 9 hours after stress loading. Chemical constituents such as Ca, P, Zn and catecholeamines in rats' urine were determined by ICPAES for Ca, P, Zn and HP-LC with ECD for catecholeamines.
1. Every stress loading experiment resulted in increasing P excretion in urine against before stress loading. This increasing P excretion in urine lasted for 9 hours in some cases.
2. Reversely, Ca excretion in urine after experiment was slightly decreased against before stress loading.
3. Urinary epinephrine significantly increased during stress loading and ten or more weeks old rats excreted on much epinephrine for 6 hours or more.
By stress loading, rats consume so much energy and a large quantity of phosphate is used in their body. The bone which is storageplace of phosphate supplies so much phosphate for blood to produce energy. Thus, bone mass decrease by stress loading. Less
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