| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Research Abstract |
Interests in the effects of chirality on the aggregation properties has led to the present study. In this study, the amphiphiles, which incorporate an assynmetric carbon atom in the middle of the molecule, N, N, N, N', N'-pentamethyl- N'-(2, 3-dihydroxypropyl) diiodide with chains of 12 - 16 carbons in length (Fig. 1), were synthesized and the influence of hydrophobic chain length and stereo isomerism of molecular on the phisico-chemical parameters were evaluated, with a view to more precise definition of this type of cationic amphiphiles newly synthesized. The objective of much of this research is to develop a systematic approach that would provide a better understanding of the phisicochemical properties of the optically active amphiphiles.
A gel-lamella liquid crystalline transition occurred at the constant temperature (Tc), when a moisture content was higher than 20 wt%. The temperature and the enthalpy of phase transition increased as the number of carbon of an acyl chain length of amphiphile increased.
Calorimetric measurement by differential scanning calorimeter (DSC) showed that approximately twelve water molecules bound per each amphiphile.
Furthermore, it was confirmed by means of transmission electron microscope (TEM) that these amphiphiles prepared various types of aggregates, such as small unilamellar vesicles (SUV), multilamellar vesicles (MLV) and lamellae in water by sonication.
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