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Studies on Biologically Active Substances in Marine Worms, Especially on Toxins of The Ribbon Worm

Research Project

Project/Area Number 01560224
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionHiroshima University

Principal Investigator

MIYAZAWA Keisuke  Applied Biological Science, Professor, 生物生産学部, 教授 (20034457)

Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsHelminth / Worm / Tetrodotoxin / Biological Active / Nemertean / Toxic compound / 蠕虫類 / ヒモムシ
Research Abstract

Marine helminth worms (Platyhelminthes, Nemertean, Nematyhelminthes, Trochelminthes, Endoprocta, Annelida and so on) don't have hard carapaces or shells to protect against enemies and are not able to swim quickly to escape from them. And many of them are carnivorous. Therefore they have been assume d or shown to have some chemical agents instead of shells or weapons. Recently we have found that some worms such as flatworm and ribbon worm possess tetrodotoxin (TTX). Some results show that TTX is used as biological defense agent in these organisms. Under these backgrounds, some experiments were conducted and following results were obtained.
1) In addition to known TTX-containing ribbon worm such as Lineus fuscoviridis, some other nemerteans were shown to possess this toxin by means of HPLC and GC-MS. Among the various organs of the ribbon worm L. fuscoviridis, provoscis have the highest potency (max. 1040 MU/g) followed by epidermis. Mucus also have remarkable toxicity.
2) Some annelids such as Lepidonotus spp. and some sea anemones such as Actinia sp. were shown to have lethal potencies (max. 180 MU/g), originating from TTX and its related substances.
3) The distribution of TTX related substances in benthic animals and planktons inhabiting in the Seto Inland Sea and substratums of that sea near Hiroshima were surveyed.
5) Rather strong antimicrobial activities were detected in some worms such as ribbon worms.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] K.MIYAZAWA: "Organic distribution of tetrodotoxin and its related substances in the ribbon worm Lineus fuscoviridis" In preparation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.MIYAZAWA: "Detection of TTX and its related substances in the environments of the Seto Inland Sea" In preparation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A.E.ALII: "Tetrodotoxin and related substances in a ribbon worm Cephalothrix m linearis(Nemertean)" TOXICON. 28. 1081-1093 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 宮澤 啓輔(共同執筆): "身近なバイオテクノロジ-" 広島大学放送教育実施委員会, 169 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. MIYAZAWA: ""Organic distribution of tetrodotoxin and its related substances in the ribbon worm Lineus fuscoviridis ""

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. MIYAZAWA: ""Detection of TTX and its related substances in the environments of the Seto Inland Sea. ""

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. E. ALLI: ""Tetrodotoxin and related substances in a ribbon worm Cephalothrix (Nemertean)"" Toxicon. 28. 1089-1093 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. MIYAZAWA: ""Presents from the Sea"" "Mijikana Biotechnology". Hiroshima Daigaku Housou Kyouiku Jisshi Iinkai. 113-128 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.MIYAZAWA: "Organic distribution of tetrodotoxin and its related substances in the ribbon worm Lineus fuscoviridis" In preparation.

    • Related Report
      1990 Annual Research Report
  • [Publications] K.MIYAZAWA: "Detection of TTX and its related substances in the environments of the Seto Inland Sea" In preparation.

    • Related Report
      1990 Annual Research Report
  • [Publications] A.E.ALII: "Tetrodotoxin and related substances in a ribbon worm Cephalothrix m linearis(Nemertean)" TOXICON. 28. 1081-1093 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 宮澤 啓輔(共同執筆): "身近なバイオテクノロジ-" 広島大学放送教育実施委員会, 169 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Keisuke MIYAZAWA et al.: "Organic distribution of TTX and its related compounds in the ribbon worm Lineus fuscoviridis"

    • Related Report
      1989 Annual Research Report
  • [Publications] Keisuke MIYAZAWA et al.: "Detection of TTX snd its related compounds in the substratum ob the Seto Inland Sea"

    • Related Report
      1989 Annual Research Report
  • [Publications] Keisuke MIYAZAWA et al.: "Detection of TTX and its related compounds in some benthic organisms inhabiting the Seto Inland Sea"

    • Related Report
      1989 Annual Research Report
  • [Publications] 柴田承二編: "新編生物活性天然物質" 医歯薬出版, 459 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 広島大学放送教育実施委員会編: "身近なバイオテクノロジ-" 169 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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