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Pathological Research of Diffuse Lung Disease

Research Project

Project/Area Number 01570172
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MATSUBARA Osamu  Tokyo Medical and Dental University, Department of Pathology, Associate Professor, 医学部, 助教授 (40107248)

Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsLung fibrosis / Interstitial pneumonitis / Collagen / 間貭性肺炎 / 間質性肺矣 / 線維化
Research Abstract

1. Eight cases of normal lung and three cases of lung fibrosis are studied. The fresh lung specimens were sliced 10 microns by a cryostat, placed on slide glasses, treated by pepsin, and washed and rinsed. The rinsed fluid was collected and analysed for collagen subtypes by DEAE cellulose chromatography. Before and after that treatment, slide glasses were stained by elastica van Gieson, reticulin fiber stain, and Masson trichrome. They were also stained for anti-Type I,III,IV and V collagen using ABC method. 2. The fresh samples of those lung were homogenized, solubilized by pepsin treatment, and analysed for Type I and III collagen. The ration of alpha I(III)/alpha I(I) was about 0.1 in normal lungs, and that was about 0.8 in fibrotic lungs. 3. These results suggest that Type III and V collagen component increased, and Type I and IV collagen decreased in fibrotic lung tissues.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] O.Matsubara,T.Sato,M.Kitagawa and T.Kasuga: "Pulmonary thromboembolism: frequency, site, and vascular change in 103 autopsy cases" Am J Cardiovascular Pathol. 2(4). 321-328 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.S.TanーLiu,O.Matsubara,H.C.Grillo and E.J.Mark: "Invasive fibrous tumor of the tracheobronchial tree:Clinical and pathologic study of seven cases" Human Pathol. 20. 180-184 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Kitagawa,Y.Kuwashima,T.Nemoto,S.Seki,O.Matsubara and T.Kasuga: "In vivo dynamics of pulmonary lymphoid cell subpopulations generated against pulmonary metastasis:evaluation by bronchoalveolar lavage fluid" Virchows Arch B Cell Pathol. 58. 365-370 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O.Matsubara,T.Kasuga,F.Marumo,H.Itoh and Y.Tashima: "Localization of 90ーkDa heat shock protein in the kidney" Kidney International. 38. 830-834 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松原 修・吉村 信行: "肉芽腫性疾患(サルコイド-シス)" 呼吸. 9(10). 1220-1226 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松原 修・吉村 信行: "肉芽腫性疾患(肺のヒスチオサイト-シスX,好酸球性肉芽腫,過敏性肺臓炎)" 呼吸. 9(11). 1357-1365 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O. Matsubara et al: "Pulmonary thromboembolism : frequency, site and vascular change in 103 autopsy cases." Am J Cardiovascular Pathol. 2. 321-328 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N. S. Tan-Liu et al.: "Invasive fibrous tumor of the tracheobronchial tree : Clinical and pathologic study of seven cases." Hum Pathol. 20. 180-184 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Kitagawa et al.: "In vivo dynamics of pulmonary lymphoid cell subpopulations generated against pulmonary metastasis : evaluation by bronchoalveolar lavage fluid." Virchows Archiv B. 58. 365-370 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O. Matsubara et al.: "Localization of 90-kDa heat shock protein in the kidney." Kidney International. 38. 830-834 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O. Matsubara et al.: "Pathology of pulmonary sarcoidosis (in Japanese)." Respiration (Kokyu). 9. 1220-1226 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O. Matsubara et al.: "Pathology of pulmonary histiocytosis X, eosinophilic granuloma and hypersensitivity pneumonitis (in Japanese)." Respiration (Kokyu). 9. 1357-1365 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O.Matsubara,T.Sato,M.Kitagawa and T.Kasuga: "Pulmonary thromboembolism:frequency,site,and vascular change in 103 autopsy cases" Am J Cardiovascular Pathol. 2(4). 321-328 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.S.TanーLiu,O.Matsubara,H.C.Grillo and E.J.Mark: "Invasive fibrous tumor of the tracheobronchial tree:Clinical and pathologic study of seven cases" Human Pathol. 20. 180-184 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Kitagawa,Y.Kuwashima,T.Nemoto,S.Seki,O.Matsubara and T.Kasuga: "In vivo dynamics of pulmonary lymphoid cell subpopulations generated against pulmonary metastasis:evaluation by bronchoalveolar lavage fluid" Virchows Arch B Cell Pathol. 58. 365-370 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] O.Matsubara,T.Kasuga,F.Marumo,H.Itoh and Y.Tashima: "Localization of 90ーkDa heat shock protein in the kidney" Kidney International. 38. 830-834 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松原 修,吉村 信行: "肉芽種性疾患(サルコイド-シス)" 呼吸. 9(10). 1220-1226 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松原 修.吉村 信行: "肉芽腫性疾患(肺のヒスチオサイト-シスX,好酸球性肉芽腫,過敏性肺臓炎)" 呼吸. 9(11). 1357-1365 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tan-Liu,NS,Matsubara,O.,Grillo,HC and Mark,EJ: "Invasive fibrous tumor of the trache bronchial tree:clinical and pathologic study of seven cases" Human Pathology. 20. 180-184 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Matsubara,O,Sato,T,Kitagawa,M,Kasuga,T: "Pulmonary thromboembolism:frequency,site,and vascular change in 103 autopsy cases" American Journal of Cardiovascular Pathology. 2. 321-328 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Matsubara,O,Kitagawa,M and Kasuga,T Kuwashima,Y,Nemoto,T,and Seki,S,: "In vivo dynamics of pulmonary lymphoid cell subpopulations generated against pulmonary metastasis:evaluation by bronchoalveolar lavage fluid" Virchows Archiv B.

    • Related Report
      1989 Annual Research Report
  • [Publications] Matsubara,O, Kasuga,T,and Kuwashima,Y,: "Responses of a murine B16 melanoma to pharmacotherapy studied and compared with differnt assay system" Journal of Cancer Research and Clinical Oncology.

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉村信行,松原修,田村厚久,赤川志のぶ,春日孟: "肺胞蛋白症4例の臨床病理学的検討" 日本病理学会会誌.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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