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Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease)

Research Project

Project/Area Number 01570181
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionFukuoka University

Principal Investigator

KIKUCHI Masahiro  Fukuoka Univ., Sch. Med., Professor, 医学部, 教授 (80078774)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Kohichi  Fukuoka Univ., Sch. Med., Assistant, 医学部, 助手 (50203766)
IWASKI Hiroshi  Fukuoka Univ., Sch. Med., Professor, 医学部, 教授 (90101170)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
KeywordsKikuchi's disease / Tubuloreticular structure / 2'5'Oligoadenilate acetate synthetase / Interferon / HHV-6 / plasmacytoid monocyte / HHVー6 / 組織球性壊死性リンパ節炎 / インタ-フェロンアルファ- / 2'5'オリゴアデニ-ル酸合成酵素 / ヒトヘルペスウイルス6型 / 組織球性壊死性リンパ節炎(HNL) / 2´5´オリゴアデニル酸(2ー5A)合成酵素活性 / 増殖細胞 / 二重染色 / CD8(cytotoxic / suppressor)
Research Abstract

Histiocytic necrotizing lymphadenitis (HNL) was first reported in 1972 as a lymphadenitis with focal proliferation of retucular cells accompanying numerous nuclear debris by us. We gathered over 300 cases. The patients with HNL has characteristic clinical findings of an occurrence of adolescence in preference to female, localized lymphadenopathy on the neck, frequent leukopenia with a few atypical lymphocytes in peripheral blood and fever, occasional skin rashes, and natural healing within several months with rare recurrence. HNL represents distinctive histological features, such as focal, well circumscribed lesions with aggregation of large lymphocytes, immunoblasts, plasmacytoid monocytes, histiobytes with or without phagocytosis, and karyorrectic nuclear debris, mainly in the paracortex and/or cortex, an absence of significant numbers of neutrophils, eosinophils, and plasma cells, occasional prominent indiridual cell necrosis, eosinophilic fibrin deposits, foamy cells and necrotic foci. The cells in the affected areas consisted mainly of CD8+, CD15- cytotoxic T cells with proliferating activity and non-proliferating CD4, Ki-Mlp positive plasmacytoid monocytes and lysozyme and KP1 positive histiocytes. The same lesions were found in the skin and bone marrow also in some cases. The findings indicate HNL is not lymph node lesion, but generalized disease. A high incidence of tubuloreticular structures in lymphocytes, histiocytes, and vascular endothelial cells and increased production of interferon in the affected areas, the patterns of elevated serum levels of 2'5' oligoadenylate acetate synthetase in the early stage of disease suggested a viral nature of the lesion. We detected HHV-6 antigens with strong membranous reactions of clustering large lymphoid cells, but no difference of HHV-6 genomes in amounts between HNL and contral groups. The results postulate some role of HHV-6 in developing the lesion.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 住吉 慶明他: "組織球性壊死性リンパ節炎における2'5'オリゴアデニル酸合成酵素活性" 医学のあゆみ. 157. 607-608 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi,M.: "Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) in Japan." Am.J.Surg.Pathol. 15. 197-198 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohshima,K.et al.: "Proliferating cells in histiocytic necrotizing lymphadenitis." Virch.Arch.B. 61. 97-100 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sumiyoshi,Y.et al.: "A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement" Virch.Arch A.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sumiyoshi,Y.et al.: "Alpha-interferon in Kikuchi's disease." Virch.Arch.B. 61. 201-207 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi,M.et al.: "Histiocytic necrotizing lymphadenitis:Clinicopathologic,immunologic,and HLA typing study.In "Lymphoid Malignancy:Immunology and Cytogenesis"" Field & Wood, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi,M.et al.: "Kikuchi's disease (histiocytic necrotizing lymphadenitis) In "Human Herpesvirus-6"" Elsevier Science Publishers, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi, M.: "Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto Disease) in Japan." Am. J. Surg. Pathol.15. 197-198 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohshima, K. et al.: "Lymph nodes in incipient adult T-cell leukemia-lymphoma with Hodgkin's disease-like histologic Features." Cancer. 67. 1622-1628 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sumiyoshi, Y. et al.: "2', 5'-oligoadenylate syntherase in histiocytic necrotizing lymphadenitis." Igaku no Ayumi (in Japanese). 157. 607-608 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohsima, K. et al.: "Proliferating cells in histiocytic necrotizing lymphadenitis." Virch. Arch. B. 61. 97-100 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sumiyoshi, Y. et al.: "Alpha-interferon in Kikuchi's disease." Virch. Arch B. 61. 201-207 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohshima, K. et al.: "Human T-cell leukemia virus type I associated lymphadenitis." Cancer. 69. 239-248 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi, M. et al.: "Kikuchi's disease (histiocytic necrotizing lymphadenitis). In "Human Herpesvirus-6"" Elsevier Science Publishers B. V.175-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sumiyoshi, Y. et al.: "A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement." Virch Arch A.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kikuchi, M. et al.: field & Wood, N. Y.Histiocytic necrotizing lymphadenitis : Clinicopathologic, immunologic, and HLA typing study. In "Lymphoid Malignancy : Immunology and Cytogenesis", (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 住吉 慶明 他: "組織球性壊死性リンパ節炎における2′5′オリゴアデニル酸合成" 医学のあゆみ. 157. 607-608 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kikuchi,M.: "Histiocytic necrotizing lymphadenitis(Kikuchi-Fujimoto disease)in Japan." Am.J.Surg.Pathol.15. 197-198 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ohshima,K.,et al.: "Proliferating cells in histiocytic necrotizing lymphadenitis." Virch.Arch.B. 61. 97-100 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sumiyoshi,Y.,et al.: "A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement." Virch.Arch.A.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kikuchi,M.et al.: "Histiocytic necrotizing lymphadenitis:Clinicopathologic,immuno-logic,and HLA typing study.In "Lymphoid Malignancy:Imunology and Cytogenesis"" Field & Wood, (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 住吉 慶明,菊池 昌弘,大島 孝一,竹下 盛重,増田 雄一,南島 洋一,: "組織性壊死性リンパ炎における2'5'オリゴアデニル酸合成酵素活性" 医学のあゆみ accepted.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kohichi Ohshima: "Lymph Node in Incipient Adult T Cell Leukemia/Lymphoma with Hodgikin's DiseaseーLike Histological faturs" CANCER RECEARCH.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kohichi Ohsima,Masahiro Kikuchi,Yuhichi Masuda,Shinichi Kobari,Yoshiaki Sumiyoshi,Fuyuki Eguchi,Hidohito Mohtai,: "Defectiv provirus from of human Tーcell leukemia virus type I in adult Tーcell leukemia/lymphoma:Clinicopathologic featurs." Canser resarch.

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Ohshima,M.Kikuchi,Y.Masuda,S.Kobari,F.Eguchi,H.Mohtai,N.Kimura,M.Takeshita: "Bc1ー2 gene and prognosis of Bーcell Lymphoma" Leukemia Lymphoma.

    • Related Report
      1990 Annual Research Report
  • [Publications] Masahiro Kikuchi: "Histiocytic necrotizing lymphadenitis in Japan" Reactiv Lymphadenopathies:New Concepts and Controversies Society for Hematopathology 1991,3,17.

    • Related Report
      1990 Annual Research Report
  • [Publications] 住吉 慶明,菊池 昌弘,大島 孝一,増田 雄一,竹下 盛重: "組織性壊死性リンパ節炎とヘルペス6型ウイルスとの関係" 第80回日本病理学会総会.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kikuchi M,Sumiyoshi Y,Masuda Y;: "Human Herpesvirusー6 in histiocytic necrotizing lymphadenitis.Eds:Ablaski DV,Krueger GRF,Salakuddin SZ," Elsevir Science Publishers B.V.,

    • Related Report
      1990 Annual Research Report
  • [Publications] Kikuchi M.,takeshita M.Eimoto T.,Iwasaki H.,Ninamishima Y.: "Limphoic Malignancy:Immnology and Cytogenisis" Field & Wood,N.Y.,

    • Related Report
      1990 Annual Research Report
  • [Publications] Masahiro KIKUCHI,et al.: "Histiocytic Necrotizing Lymphadenitis:Clinicopathologic,Immunologic,and HLA Typing STudy.p.251ー257 In“LYMPHOID MALIGNANCY:Immunocytology and Cytogenetics"" FIELD & WOOD, (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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