Analysis of the Mechanisms of Skin Tumor Promotion in Mice Resistant and Sensitive to TPA.
| Project/Area Number |
01570194
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
WATANABE Hiromitsu Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Associate Professor., 原爆放射能医学研究所, 助教授 (00034653)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Akihiro Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Professor., 原爆放射能医学研究所, 教授 (60034633)
|
|---|
| Project Period (FY) |
1989 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | C57BL mouse / DBA mouse / Initiation-promotiom / Skin tumor / MNNG / TPA / Benzoyl peroxide / SOD activity |
|---|
| Research Abstract |
Strain difference of mouse skin tumor promotion by benzoyl peroxide (BzP) and by 12-0-Tetradecanoyl-Phorbol-13-Acetate (TPA) was examined. After initiation by 4.0mu mol of N-Methyl-N'-nitro-N-nitrosoguannidine (MNNG), 8-week-old female DBA/2N, C57BL/6, C3H/C^b_s, and C3H/HeN mice (in progress) were promoted by 10 mg or 20 mg BzP or 10 n mol of TPA for 30 weeks. The incidence of skin tumors in DBA, C^b_s and C57BL mice promoted by TPA were 72%, 58% and 37%, respectively. By promotion with 10 mg or 20 mg Bzp, the incidences were 74% and 35% in DBA mice, 6% and 25% in C57BL mice, and 0% in C^b_s mice. The results suggest that genetic factors controlling susceptibility to TPA promotion also control sensitivity to other classes of promoters.
|
Report
(3 results)
Research Products
(8 results)
