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Studies on the protective immunity to Strongyloides infection in mice infected with S. venezuelensis

Research Project

Project/Area Number 01570218
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 寄生虫学(含医用動物学)
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SATO Yoshiya  University of the Ryukyus, Department of Parasitology, Professor, 医学部, 教授 (60092699)

Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
Keywordsparasitic infection / strongyloidiasis / Strongyloides venezuelensis / protective immunity / nude mouse / IL-5 / susceptibility / インタ-ロイキン5 / 寄生虫 / 免疫 / 感染防御
Research Abstract

Strongyloides venezuelensis is a rodent parasite which is infective to mice. In the present study, the murine infection model with S. venezuelensis was found to be a more useful model for the study of human strongyloidiasis than that with S. ratti, because S. venezuelensis is much more infective to mice and also because the migratory route in mice may be comparable to that of S. stercoralis in humans. The mice infected with S. venezuelensis were also found to aquire an almost complete resistance to the secondary infection after expulsion of intestinal adults of the primary infection.
Unlike the immunocompetent nu/+ mice, the hypothymic nude (nu/nu) mice were unable to expel the adult worms and no aquired resistance to rechallenge was observed among them. The expulsion of adult worm, as well as the resistance against migratory larvae in the secondary infection, were transferrable to nude mice by spleen cells from intact nu/+ mice, but not by infected serum. These results support the hypothesis that direct worm immunity and worm expulsion are a T cell-dependent phenomenon.
In another experiment in which inetrleukin-5 (IL-5) was depleted by treatment with anti-IL-5 monoclonal antibodies, the anti-IL-5 treatment did not affect worm burden and faecal egg output after primary infection. However, when mice were treated after expulsion of intestinal adults, the worm recovery from lungs after the secondary infection was the same as that in the primary infection. The results suggested that the host's protective immunity against tissuemigrating larvae was IL-5-dependent but intestinal immunity was not.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] HIDEO HASEGAWA: "Strongyloides venezuelensis Brumpt 1934 (Nematoda: Strongyloididae) collected from Rattus norvegicus in Naha,Okinawa,Japan." Japanese Journal of Parasitology. 37. 429-434 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYA SATO: "Strongyloides venezuelensis infections in mice." Internation Journal for Parasitology. 20. 57-62 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYA SATO: "Effect of spleen cells and serum on transfer of immunity to Strongyloides Venezuelensis infection in hypothymic. (nude) mice." International Journal for Parasitology. 20. 63-67 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] MASATAKA KORENAGA: "The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice." Immunology. 72. 502-507 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] HIDEO HASEGAWA: "Strongyloides venezuelensis Brumpt 1934(Nematoda:Strongyloididae) collected from Rattus norvegicus in Naha, Okinawa, Japan." Japanese J. Parasitology. 37-6. 429-434 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYA SATO: "Strongyloides venezuelensis infection in mice." International J. for Parasitology. 20-1. 57-62 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIYA SATO: "Effect of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic (nude) mice." International J. for Parasitology. 20-1. 63-67 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] MASATAKA KORENAGA: "The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice." Immunology. 72-4. 502-507 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshiya Sato: "Strongyloides venezuelensis infections in mice" International Journal for Parasitology. 20. 57-62 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yoshiya Sato: "Effects of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothimic (nude) mice." International Journal for Parasitology. 20. 63-67 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yoshiya Sato: "Immunoblot analysis of three antigen preparations from Strongyloides stercoralis larvae in human strongyloidiasis" Japanese Journal of Parasitology. 39. 258-266 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Masataka Korenaga: "The role of interleukinー5 (ILー5) in protective immunity to Strongyloides venezuelensis infection in mice." Immunology.

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐藤良也: "Strongyloides venezuelensis infections in mice" International Journal for Parasitology. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 佐藤良也: "Effect of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic(nude)mice." International Journal for Parasitology. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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