• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Quantitative Analysis of Tumor Growth Dynamics Using Screening Data

Research Project

Project/Area Number 01570328
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

YAMAGUCHI Naohito  University of Occupational and Environmental Health, Dept. Environmental Epidemiology, Associate professor, 医学部, 助教授 (80119031)

Co-Investigator(Kenkyū-buntansha) IKEDA Masato  University of Occupational and Environmental Health, Dept. Clinical Epidemiology, 医学部, 助教授 (90038761)
YOSHIMURA Takesumi  University of Occupational and Environmental Health, Dept. Clinical Epidemiology, 医学部, 教授 (20037435)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsStomach cancer / Screening / Tumor growth / Mathematical model / Epidemiology / 生長ダイナミックス / 腫瘍径 / 自然史 / 連続生長モデル
Research Abstract

We developed a new approach using mathematical modeling technique to estimate the screening sensitivity and the growth rate of cancer based on screening data. Using this method, the sensitivity of screening test with indirect X-ray examination was estimated in relation to the tumor diameter. This method has an advantage over the conventional stochastic progression model, since it can formulate the growth of a malignant tumor as a continuous process instead of unrealistic stepwise progression.
We also analyzed the incidence rate of stomach cancer in different histologic subtypes using a mathematical model of multistage cancer induction and exponential tumor growth. We found that the growth rate as well as the process of cancer induction differ by histologic subtypes. In particular, the induction and growth showed marked differences between well and poorly differentiated subgroups.
We estimated the screening sensitivity for well and poorly differentiated stomach cancer, separately and that for the whole stomach cancer, using our method. We found no difference in the screening sensitivity between these two groups.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Yamaguchi,N.,et al.: "Use of tumor diameter to estimate the growth kinetics of cancer and sensitivity of screening tests." Environmental Health Perspectives. 87. 63-67 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamaguchi,N.et al.: "Analysis of stomach cancer incidence by histologic subtypes based on a mathematical model of multistage cancer induction and exponential growth." Japanese Journal of Cancer Research. 81. 1109-1117 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Naohito YAMAGUCHI, et at: "Use of tumor diameter to estimate the growth kinetics of cancer and sensitivity of screening tests." Environmental Health perspectives. 87. 63-67 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Naohito YAMAGUCHI, et al.: "Analysis of stomach cancer incidence by histologic subtypes based on a mathematical model of multistage cancer induction and exponential growth." Japanese Journal of Cancer Research. 81. 1109-1117 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamaguchi,N.,et al.: "Use of tumor diameter to estimate the growth kinetics of cancer and sensitivity of screening tests." Environmental Health Perspectives. 87. 63-67 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamaguchi,N.,et al.: "Analysis of stomach cancer incidence by histologic subtypes based on a mathematical model of multistage cancer induction and exponential growth." Japanese Journal of Cancer Research. 81. 1109-1117 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山口直人: "Use of tumor diameter to estimate the growth kinetics of cancer and sensitivity of screning tests" Enviromental Health Perspective. 87. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山口直人: "成人病スクリ-ニングプログラムの数量的評価の理論と方法" 産業医科大学雑誌. 12. 83-88 (1990)

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi