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Role of P40^x on Chronic Bronchobronchiolitis and other HTLV-1 Related Diseases

Research Project

Project/Area Number 01570421
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

HONDA Ichiyou  Faculaty of Medicine, Clinical and Laboratory Medicine associated professor, 医学部附属病院, 助手 (00125650)

Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsChronic bronchobronchiolitis / HTLV-1 / Western blot method / P40^x / DNA analysis / Pseudouidine / 1-Methyladenosine / Bronchial permeability / p40^x / HTLVーI / びまん性間質性肺炎 / プロウィルDNA / PCR / 抗HTLD-I抗体 / ウェスタン・ブロット法 / RNA / 修飾塩基 / ^<13>I-アルブミン
Research Abstract

Chronic bronchobronchiolitis is a very complicated disease which involves pulmonary vascular damage and peribronchial fibrosis as its terminal manifestations. And terminal infection with P. aeruginosa produces an increase in airway mucosal permeability to albumin. We investigated the significance of pX gene derived P-40 as an etiological marker of viral replication and the relationship of clinical manifestations in IITLV--L related discases including 4 cases of clinically diagnosed chronic bronchobronchiolitis by the method of Western blot analysis with randomly selected HTLV-L antibody positive sera.
P-40 positive cases were rioted in all cases of chronic bronchobronchiolitis with more frequent population than other underlying diseases. Three out of 4 those cases were associated with lymphopenia and atypical lymphocytes without any explaflatory reason. The mechanism may involve replated infections with infiltration of a few HTI., V-l infected cells and progressive fibrosis. Another possibility is considered that cell infiltrarion induces fibroblasts through localized alveolar macrophaze and that, interstitial fibrosis progresses as a result. According to the DNA analysis of tumor cell line(HuT-102), high contents of 1-methyladenosine and pseudouridine, the modified nucleosides in the UTLV-L infected cell might follow DNA synthesis.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 星野 敦,本田 一陽,石森 章,伊藤 邦彦,水柿 道直,能勢 真人: "免疫学的原理に基づいた検査法の進展(5)血液学領域:血液疾患の分子免疫学的アプロ-チ" 臨床病理. 38. 756-764 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroshi Ishihara,Ichiyou Honda,Sanae Shimura,Hidetada Sasaki,Tamotsu Takishima: "Role of Chronic Pseudomonas aeruginosa Infection in Airway Mucosal Permeability" Chest. 100. 1607-1613 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda Akira Ishimori (Kazuo Sugamura): "Role of P40^X on Chronic Bronchobronchiolitis and other HTLV-1 related Diseases" The Tohoku Journal of Experimental Medicine.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda,Akira Ishimori,Kunihiko Itoh,Michinao Mizugaki: "Urinary Exeretion Level of Modified Nucleosides in Malignant and Nonmalignant Diseases" Cancer Research.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 本田 一陽,石森 章,遠藤 眞知子,長原 信行,八巻 晴美,狩野 明: "各種病態下におけるリンパ球サブポピュレ-ションの解析(1)癌・炎症性疾患" 臨床病理.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 本田 一陽,石森 章,遠藤 眞知子,長原 信行,八巻 晴美,狩野 明: "各種病態下におけるリンパ球サブポピュレ-ションの解析(2)サブセットの相関からみた免疫応答" 臨床病理.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Atsushi Hoshino, Ichiyou Honda, Akira Ishimori, Kunihiko Itoh, Michinao Mizugaki, Masato Nose: "Molecular and immunological Approach to Hematological Disease : Dtection and analysis of Intracellular Modified Nucleosides by Flowcytometry" Japanese Journal of Clinical Pathology. 38, No. 7. 756-764 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroshi Ishihara, Ichiyou Honda, Sanae Shimura, Hidetada Sasaki, Tamotsu Takishima: "Role of Chronic Pseudomonas aeruginosa Infection in Airway Mucosal Permeability" Chest. 100, No. 6. 1607-1613 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda, Akira Ishimori, Kazuo sugamura: "Role of P40^x on Chronic Bronchobronchiolitis and Other HTLV-1 related diseases" The Tohoku journal of Experimental Medicine.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda, Akira Ishimori, Kunihiko Itoh, Michinao Mizugaki: "Urinary Excretion Level of Modified Nucleosides in Malignant and Nonmalignant Diseases" Cancer Research.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda, Akira Ishimori: "Analysis of Lymphocyte Subpopulations under the Pathological States (1) Malignancy and Inflammatory Diseases" Japanese Journal of Clinical Pathology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ichiyou Honda, Akira Ishimori: "Analysis of Lymphocyte Subpopulations under the Pathological States (2) Immune response" Japanese Journal of Clinical Pathology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 星野 敦,本田 一陽,石森 章,伊藤 邦彦,水柿 道直,能勢 真人: "免疫学的原理に基づいた検査法の進展(5) 血液学領域:血液疾患の分子免疫学的アプロ-チ" 臨床病理. 38. 756-764 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hiroshi Ishihara,Ichiyou Honda,Sanae Shimura,Hidetada Sasaki,Tamotsu Takishima: "Role of Chronic Pseudomonas acruginosa Infection in Airway Mucosal Permeability" Chest. 100. 1607-1613 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ichiyo Honda,Akira Ishimori(Kazuo Sugamura): "Role of P40^x on Chronic Bronchobronchiolitis and other HTLVー1 related Diseases" The Tohoku Journal of Experimental Medicine.

    • Related Report
      1991 Annual Research Report
  • [Publications] Ichiyou Honda,Akira Ishimori,Kunihiko Itoh,Michinao Mizugaki: "Urinary Exeretion Level of Modified Nucleosides in Malignant and Nonmalignant Diseases" Cancer Research.

    • Related Report
      1991 Annual Research Report
  • [Publications] 本田 一陽,石森 章,遠藤 眞知子,長原 信行,八巻 晴美,狩野 明: "各種病態下におけるリンパ球サブポピュレ-ションの解析(1)癌・炎症性疾患" 臨床病理.

    • Related Report
      1991 Annual Research Report
  • [Publications] 本田 一陽,石森 章,遠藤 眞知子,長原 信行,八巻 晴美,狩野 明: "各種病態下におけるリンパ球サブポピュレ-ションの解析(2)サブセットの相関からみた免疫応答" 臨床病理.

    • Related Report
      1991 Annual Research Report
  • [Publications] 本田 一陽,他: "各種病態下におけるリンパ球サブポピュレ-ションの解析" 臨床病理.

    • Related Report
      1990 Annual Research Report
  • [Publications] J.Honda,et al.: "Polyclonal integration of HTLVーI provirus DNA in BAL lymphocytes detected by PCR method." Amer Rev Resp Dis.

    • Related Report
      1990 Annual Research Report
  • [Publications] H.ISHIHARA, I.HONDA et: "Pseudomonas aeruginosa infection increases airway mucosal permeability in chronic bronchitis" AM REV RESPIR DIS.

    • Related Report
      1989 Annual Research Report
  • [Publications] I.HONDA et al: "Analysis of HTLV-I infectious pattern by Western blot method." J.Infect.Dis.

    • Related Report
      1989 Annual Research Report
  • [Publications] I.HONDA: "The urinary level of 1-methyl adenosine and peudouridine in malignancy or in nonmalignancy" Cancer Research.

    • Related Report
      1989 Annual Research Report
  • [Publications] 星野敦・本田一陽他: "血液疾患における分子・免疫学的アプロ-チ" 臨床病理.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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