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Medullary Reticular Neurons Related to Hypoxic Respiratory Depression

Research Project

Project/Area Number 01570424
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

ARITA Hideho  Univ. of Tsukuba. Inst. Clin. Med. Sci., Assist. Prof., 基礎医学系, 講師 (20075576)

Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordshypoxic respiratory depression / serotonin / nucleus paragigantocellularis lateralis / control of breathing / 呼吸抑制 / 脳幹網様体 / 呼気性ニュ-ロン / 延髄 / セロトニン / 微量圧注入法 / 呼吸調節
Research Abstract

We have performed the following three distinct experiments.
1. Respiratory effect of intravertebral arterial injections of hypoxic or normoxic saline has been studied in sino-aortic denervated, vagotomized, artificially ventilated cats. Injections of N_2-saturated saline (a central hypoxic loading) evoked a clear respiratory depression (a decrease in phrenic nerve activity) with a short onset latency within a few seconds. Similar hypoxic respiratory depression was observed after decerebration at the mid-collicular level. Therefore, it was concluded that the structures responsible for the hypoxic respiratory depression were located within ponto-medullary regions supplied by the vertebral-basilar artery.
2. We have examined changes in activity of medullary reticular neurons with non-phasic discharges during the forementioned hypoxic respiratory depression. Both excitatory and inhibitory units were isolated, and most of them were found in the rostral vetrolateral medulla, corresponding to the nuleus paragigantocellularis lateralis.
3. Since it has been reported that brainstem serotonergic system was depressed during the central hypoxic loading, we have tested responsiveness of medullary inspiratory neurons to direct applications of serotonin, using a multi-barreled micropipette. The medullary inspiratory neurons examined herein were classified into two subgroups based upon the differences in firing patterns. The inspiratory neurons with decrementing firing pattern were excited by serotonin application, whereas the inspiratory neurons with augmenting firing pattern were inhibited. These results suggest a possibility that inspiratory premotor neurons supplying the dilator muscles of upper airway might be more sensitive to the hypoxic respiratory depression.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Arita, H., Ichikawa, K. and Ochiishi, M.: "Pressor response and respiratory depression evoked by intravertebral arterial injections of hypoxic saline。" J.Autonomic Nervous System. 28. 27-33 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kogo, N. and Arita, H.: "In vivo study on medullary H^+ーsensitive neurons." J. Applied Physiology. 69. 1408-1412 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arita, H. and Ochiishi, M.: "Opposing effects of 5ーhydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns." J. Neurophysiology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arita, H. Ichikawa, K. and Ochiishi, M.: "Pressor response and respiratory depression evoked by intravertebral arterial injections of hypoxic saline." J. Autonomic Nervous System. 28. 27-33 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kogo, N. and Arita, H.: "In vivo study on medullary H^+-sensitive neurons." J. Applied Physiology. 69. 1408-1412 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arita, H. and Ochiishi, M.: "Opposing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns." J. Neurophysiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ARITA,H.et al.: "Pressor response and respiratory depression evoked by introvertebral arterial injections of hypoxic saline." J.Autonomic Nervous System. 28. 27-33 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] ARITA,H.et al.: "Possible locations of pHーdependent chemoreceptors" Brain Research. 485. 285-293 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] KOGO,N.et al.: "In vivo study on medullary H^+ーsensitive neurons." J.Applied Physiology. 69. 1408-1412 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] ARITA,H.et al.: "Opposiong effects of 5ーhydroxy tryptamine on two types of medullary inspiratory neurons" J.Neurophysiology. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Arita,H.et al.: "Pressor response and respiratory depression evoked by intravertebral arterial injection of hypoxic saline" Journal of Autonomic Nervous System. 28. 27-33 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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