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Neurochemical analysis on a brain of pure pallidal degeneration with special reference to the termination of GABA ergic pallido-thalamic tract in the thalamus

Research Project

Project/Area Number 01570441
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

KWAK Shin  National Institute of Neuroscience. Chief of laboratory., 神経研究所, 室長 (40160981)

Co-Investigator(Kenkyū-buntansha) AIZAWA Hitoshi  National Institute of Neuroscience. Research fellow., 神経研究所, 流動研究員
NUKINA Nobuyuki  University of Tokyo, Dep.Neurology, Instructor., 医学部, 助手 (10134595)
Project Period (FY) 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1989: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsGlobus Pallidus / Basal ganglia / Pallidothalmic tract / Neurotransmitter / GABA / Akinesia / Progressive pallidal degeneration / アキネジア
Research Abstract

1) Neurotransmitter markers were measured in brain regions of a very rare case of pure pallidal degeneration (PPD) as compared with 16 controls. Gamma-aminobutylate (GABA) concentration was remarkably decreased in extemal (GPe) and internal (GPi) pallidum (GP) and subthalamic nucleus (ST), glutamate concentration was increased markedly in GPi and ST, and choline acetyltransferase (CHAT) activities in GP, ST, ventroanterior (VA) and ventrolateral (VL) nucleus of the thalamus. Noradrenaline concentration in GP was decreased moderately. Dopaminergic and serotonergic systems showed no remarkable change in all the regions examined. These results suggest that the changes of neurotransmitter markers reflect selective degeneration of GP neurons and their efferent fibers, and also of terminals of striatopallidal GABAergic fibers and probably noradrenergic fibers within GP. Because ChAT activities were increased only in GP and its terminal areas, increase of ChAT activity might be a representation of a compensatory reaction against GP neuronal damage in PPD brain. These sets of neurochemical changes are the pathophysiological basis of the characteristic slow movement in PPD patient. 2) Using microdissection method, fine distribution of GABA in the thalamus was analyzed in PPD and 4 control brains. GABA concentration was specifically decreased in PPD brain in the ventro-oral nucleus of VL, which indicates that pallidothalamic fibers contain GABA as a neurotransmitter in the human brain and terminate in the very restricted area of VL thalamus.

Report

(2 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Aizawa H.: "Neurochemical analysis on a brain of pure pallidal degeneration." J.Neurological Sciences.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aizawa H.: "Selective decrease of GABA concentration in the specific thalamic nuclei of pallidal degeneration." J.Neurological Sciences.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 相澤仁志: "脳神経伝達物質" 臨床成人病. 19. 1313-1319 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shinozaki H.: "Specific lesions of rat spinal interneurons induced by systemic administration of acromelic acid,a new potent kainate analogue." Brain Research. 503. 330-333 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 松前光紀: "孔脳症の1症例" Neurologia medico-chirurgia(Tokyo). 29. 347-351 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 貫名信行: "アルツハイマ-病における異常蛋白質" 蛋白核酸酵素. 34. 1725-1732 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 砂田芳秀: "図説内科診断治療講座15巻,パ-キンソン症候群と類縁疾患.“移植療法の現況と展望"(分担執筆)" メジカルビュ-社, 262 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kwak S.: "Amino Acids:chemistry,biology and Medicine.“small neurons in the lower spinal cord are selectively damaged in the spastic rat by acromelic acid."(分担執筆)" ESCOM Science Publishers B.V.(Leiden), (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aizawa H., Kwak S., Shimizu T., Shibasaki H.& Mannen T.: "Neurochemical analysis on a brain of pure pallidal degeneration." J.Nuerol.Sci.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aizawa H.& Kwak S.: "Selective decrease of GABA concentration in the specific thalamic nuclei of pallidal degeneration."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aizawa H.: "Neurochemical analysis on a brain of pure pallidal degeneration." J.Neurological Science.

    • Related Report
      1989 Annual Research Report
  • [Publications] Aizawa H.: "Selective decrease of GABA cocentration in the aspecific thalamic nuclei of pallidal degeneration." J.Neurological Science.

    • Related Report
      1989 Annual Research Report
  • [Publications] 相澤仁志: "脳神経伝達物質" 臨床成人病. 19. 1313-1319 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shinozaki S.: "Specific lesions of rat spinal interneurons induced by systemic administration of acromelic acid,a new potent Kainate analogue." Brain Research. 503. 330-333 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松前光紀: "孔脳症の1症例" Neurologia medicoーchirurgia(Tokyo). 29. 347-351 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 貫名信行: "アルツハイマ-病における異常蛋白質" 蛋白質核酸酵素. 34. 1725-1732 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 砂田芳秀: "図説内科診断治療講座15巻、パ-キンソン症候群と類縁疾患、移植療法の現況と展望(分担執筆)" メジカルビュ-社, 262 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kwak S.: "Amino Acids:Chemistry,Biology and Medicine,Small neurons in the lower spinal cord are selectively damaged in the spastic rat by acromelic acid.(分担執筆)" ESCOM science publishers B.V., (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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