| Project/Area Number |
01570462
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KOIWA Yoshiro Tohoku University, First Dept. Int. Med., Assistant Professor., 医学部, 助教授 (80091685)
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| Co-Investigator(Kenkyū-buntansha) |
TEZUKA Funiaki Tohoku University, Research Institute for Tuberculosis & Cancer, Assistant Profe, 医学部, 助教授 (60004892)
SHIRATO Kunio Tohoku University, First Dept. Int. Med., Assistant Professor., 医学部, 助教授 (80004761)
TAKISHIMA Tamotsu Tohoku University, First Dept. Int. Med., Professor., 医学部, 教授 (20004765)
清水 芳雄 東北大学, 医学部, 助手 (90005421)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1989: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Myocardial elasticity / Cardiomyopathy / vibration analysis |
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| Research Abstract |
New clinical method for estimating left ventricular myocardial elasticity has been developed by extrapolation the theoretical equation by Advani-Lee or the dimension analysis. Human elasticity per unit myocardium (Young's modulus) can be measured non-invasively by introducing this method. Because these equation only requires non-invasive parameters of vibration mode, eigenfrequency and dimensions. After verifying the validity of this new method by comparing the unit elasticity by Advani-Lee or dimension analysis with those by standard stretch test in the physical thick-walled spherical model, this method was applied to estimate the change in myocardial elasticity in patients with hypertrophic cardiomyopathy (HCM), calculating left ventricular eigenfrequency by parametric spectrum estimation (time dependent AR modeling method) and measuring left ventricular wall thickness and dimensions by echocardiography or by left ventriculography. Left ventricular end-diastolic myocardial elasticities of HCM patients were greater than those of normal subjects. Therefore, the decrease in left ventricular compliance in HCM patients seemed to arise from an increase in myocardial elasticity.
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