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Studies on the Development of Circadian and Ultradian Rhythms in the Hypothalamo-Pituitary System in Children and Adolescents

Research Project

Project/Area Number 01570511
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionAsahikwa Medical College

Principal Investigator

OKUNO Akimasa  Asahikawa Medical College DEPT PED, Professor, 医学部, 教授 (10000960)

Co-Investigator(Kenkyū-buntansha) OKI Junichi  Asahikawa Medical College DEPT PED, Instructor, 医学部, 助手 (60152401)
AZUMA Hiroshi  Asahikawa Medical College DEPT PED, Instructor, 医学部, 助手 (00167909)
YANO Koichi  Asahikawa Medical College DEPT PED, Instructor, 医学部, 助手 (60182383)
OKA Ryuji  Asahikawa Medical College DEPT PED, Assist Professor, 医学部, 講師 (40113724)
佐々木 一弘  旭川医科大学, 医学部, 医員
鈴木 直己  旭川医科大学, 医学部, 医員
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
KeywordsCircadian Rhythm / Ultradian Rhythm / Infradian Rhythm / Growth hormone / Gonadotropin / 17-Hydroxyprogesterone / Growth Velocity / 性腺刺激ホルモン / 概日性リズム / テストステロン / 成長ホルモン欠損症 / タ-ナ-症候群 / 先天性副腎過形成 / 170Hプロケステロン
Research Abstract

Spontaneous secretory rhythms of growth hormone(GH), gonadotropins(Gn), testosterone, 17-hydroxyprogesterone(17OHP), and cortisol and weight velocity in premature infants were investigated.
1. Episodic secretory peaks of GH and Gn were already exist in early childhood and the intervals of ultradian rhythm were 3.0 hrs and 2.5 hrs in GH and Gn respectively.
2. The ultradian rhythm of GH secretion was maintained normally in the patients of pituitary dwarfism with isolated GH deficiency, even if the maximal GH level was less than 1 ng/ml. On the other hand the rhythm was obscured in the patients with multiple pituitary failure.
3. There was a definite circadian rhythm of Gn secretion in childhood and there was a marked argmentaion of the amplitude of the secretory peaks in early puberty. This augmentation was delayed in the patients with GH deficiency.
4. There was a clear circadian rhythm in testosterone secretion, high in midnight and low in day-time. Acro-phase of the testosterone rhythm was delayed 8 hrs from that of the Gn. Existence of, the testosterone rhythm seemed to predict normal sexual maturation.
5. Serum 17OHP levels were maintained low in prepubertal patients with congenital adrenal hyperplasia(CAH)on conventional dose of cortisol and were elevated at puberty. Poor control of the disease at puberty seemed to be not due to insufficient dose of cortisol. Further investigation on the effect of Gn would be required.
6. There was an infradian rhythm of 11 day-period in weight velocity of premature infants, which was independent of feeding and nursing program.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 伊藤 善也,他: "21ーHydroxylase欠損症における治療前後の下垂体ー副腎・性腺機能" ホルモンと臨床. 37. 157-160 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mitamura R,et al: "Relationship of insulin-like growth factor I level of height velocity,testosterone and oestradiol in healthy children" Acta Paediatr Scand 〔Suppl〕. 356. 127 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 矢野 公一,他: "Hypothalumic hamartomaによる思春期早発症の1例" 日独医報. 34. 396-399 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 伊藤 善也,他: "ブタLeydig細胞を用いた血清黄体化ホルモン生物活性の検討" 日本小児科学会雑誌. 93. 2193-2200 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鈴木 直己,他: "タ-ナ-症候群のGH分泌能" ホルモンと臨床. 38. 177-182 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鈴木 直己,他: "ミトコンドリア病の成長障害と成長ホルモン分泌能の関連について3症例の検討" ホルモンと臨床. 39. 421-423 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 奥野 晃正: "生体活動の周期性とホルモン分泌リズム" 日本小児科学会雑誌. 95. 1905-1908 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Zhang D-H et al: "Growth hormone secretory status in patients with Turner Syndrome" Acta Paediatr Jpn. 34. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 三田村 亮,他: "思春期にみられる身長増加促進とIGFーI・性ステロイドとの関係" 日本小児科学会雑誌. 95. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 角谷 不二雄,他: "体重増加速度の長日リズム(infradian rtythm)低出生体重児における検討" 日本小児科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Itoh Y, Sakaino T, Yano K, Okuno A, Hukusi M, Mizushima Y: "Pituitary-adrenal and gonadal function in patients of congenital adrenal hyperplasia before and after treatment." Horumon To Rinsho (Clin Endocrinol). 37 (Suppl). 157-160 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mitamura R, Itoh Y, Suzuki N, Yano K, Okuno A: "Relationship of insulin-like growth factor I level of height velocity, testosterone and oestradiol in healthy children." Acta Paediatr Scand [Suppl]. 356. 127 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yano K, Saijo M, Mitamura R, Itoh Y, Suzuki N, Okuno A: "Precocious puberty due to hypothalamic hamartoma ; Report of a case" Nitidoku-Iho (Japanisch-Deutsuche Medizinische Berichte). 34 (2). 396-399 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Itoh Y, Mitamura R, Suzuki N, Yano K, Okuno A: "Studies on serum bioactive LH using porcine Leydig cells." J Japan Pediat Soc. 93 (10). 2193-2200 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Suzuki N, Zhang D-H, Mitamura R, Itoh Y, Yano K, Okuno A: "Growth hormone secretion in Turner syndrome." Horumon To Rinsho (Clin Endocrinol). 38. 177-182 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Suzuki N, Mitamura R, Itoh Y, Yano K, Miyamoto A, Itoh J, Kusunoki Y, Oki J, Cho K, Okuno A, Iseki K: "Growth retardation in mitochondrial cytopathy and growth hormone secretion : Studies on 3 cases" Horumon To Rinsho (Clin Endocrinol). 39. 421-423 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Okuno A: "Periodicity of biological activity and hormonal secretory rhythm." J Japan Pediat Soc. 95. 1905-1908 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Zhang D-H, Yano K, Itoh Y, Mitamura R, Suzuki N, Okuno A: "Growth hormone secretory status in patients with Turner syndorome" Acta Paediatr Jpn. 34. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mitamura R, Okuno A: "Pubertal growth spurt, IGF-I, and sex steroids." J Japan Pediat Soc. 95. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kakuya H, Tsuda N, Hayashi T, Ishioka T, Shirai M, Okauno A: "Infradian rhythm in weight velocity : Studies on premature infants" J Japan Pediat Soc.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 矢野 公一,他: "性早熟症の診断と治療の最近の進歩" 小児科診療. 52. 1480-1489 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 奥野 晃正,他: "生体活動の周期性とホルモン分泌の周期性" 日本小児科学会雑誌. 95. 1905-1908 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki Naoki,et al: "Growth retardation and growth hormone secretory capacities in mitochondrial disease:studies in 3 patients" proceedings“The 4th Meeting of the Research Society for Growth Disturbance in Children. 71-76 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] DaoーHua Zhang,et al: "Growth hormone Secretorly status in patients with Turner syndrome" Acta paediatrica Japonica. 34. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三田村 亮,他: "思春期にみられる身長増加促進とIGFーI.性ステロイドとの関係" 日本小児科学会雑誌. 95. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三田村 亮: "InsulinーLike Growth Factor1" 小児内科. 22. 1621-1625 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 直己: "タ-ナ-症候群のGH分泌能" ホルモンと臨床. 38. 177-182 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 矢野 公一: "薬物刺激試験で低反応ならば成長ホルモン分泌不全と診断してよいか?" ホルモンと臨床. 38. 1251-1254 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 伊藤善也: "21-Hydroxylase欠損症における治療前後の下垂体-副腎性腺機能〜未治療16歳男児例についての検討〜" ホルモンと臨床. 37. 157 160 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 伊藤善也: "思春期男児におけるLH生物活性の変動〜ブタLeydig細胞を用いた。LH bioassayによる検討〜" ホルモンと臨床. 37. 525-528 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Mitamura Ryo: "Relationship of insulin-like growth factor 1 level to height velocity,testosteron and oestradiol in Healthy Children" Acta Paediatr.Scand.356. 127-127 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 伊藤善也: "ブタLeydig細胞を用いた血清黄体化ホルモン生物活性測定法の検討" 日本小児科学会雑誌. 93. 2193-2200 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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