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Virological and Immunological Study for Prevention of Rotavirus Gastroenteritis.

Research Project

Project/Area Number 01570540
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionSapporo Medical College

Principal Investigator

NAKATA Shuji  Sapporo Medical College, Pediatrics, Assistant Professor, 医学部, 講師 (70155745)

Co-Investigator(Kenkyū-buntansha) KOGAWA Keiko  Sapporo Medical College, Pediatrics, Instructor, 医学部, 助手
UKAE Susumu  Sapporo Medical College, Pediatrics, Instructor, 医学部, 助手
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsRotavirus gastroenteritis / Epidemiology / Rotavirus vaccine / Booster inoculation / Protective effect / Poliovirus vaccine / 干渉現象 / 随伴免疫応答 / RRVワクチン / 血清中和抗体反応 / 交差免疫 / 発症防御 / 分子疫学
Research Abstract

Epiodemiologic study for serotypes of rotaviruses detected in Sapporo showed the relative frequency of individual serotype by year. Serotypes 1 to 4 of rotaviruses were detected during consecutive 3 winter seasons. The immunity against at least four serotypes may be required to induced broad protection. Divergency of RNA pattern of rotaviruses collected in Sapporo suggested that rotaviruses were easily changed genetically.
We have conducted the clinical trial of rhesus rotavirus vaccine MMU-18006 (RRV) (serotype 3) in a welfare nursery in Sapporo. RRV was safe and highly immunogenic. Heterotypic immune response to serotypes 1,2 and 4 of human rotaviruses after RRV inoculation was not enough even after booster inoculation. Based on the serological data RRV may be effective for serotype 3 rotavirus but not enough for other serotype of rotaviruses. During the study period an outbreak of gastroenteritis due to wild strain of serotype 1 rotavirus (RV-1) occurred in the study population. Infa … More nts aged from 0 to 25 monts were divided into three groups based on the vaccine history ; booster vaccine, one dose vaccine and control group. Almost all infants were infected with RV-1 whereas the protection against RV-1 gastroenteritis was seen more in vaccine groups, especially in booster group than in control group. There was significant relationship between asymptomatic infection and higher levels of pre-outbreak antibody titers against KU (serotype 1) but not RRV ; the protection against rotavirus infection was serotype specific. If we analyzed the data in individual case, these phenomena are not so clearly mentioned. The study for local immune response and epitope specific immune response against serotype 1 rotavirus should be needed to answer this problem.
A clinical trial of the simultaneous oral administration of RRV and poliovirus vaccines was conducted in the same nursery. The interference between these two vaccines was not observed. The data showed the possibility for combined vaccination with rotavirus and poliovirus vaccines in future. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 浦沢 正三: "本邦7地域における下痢症患者便中ヒトロタウイルスの血清型別試験成績" 臨床とウイルス. 17. 132-136 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 足立 憲昭: "サル由来ロタウイルスワクチンMMUー18006株の伝播性および免疫原性に関する研究" 医学のあゆみ. 151. 67-68 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Unasawa,S: "Sorvey of human rotavirus serotypes in different locales in Japan by ELISA with mouoclonal autibodies" J.Infect.Dis.160. 44-51 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 足立 憲昭: "ロタウイルスワクチンMMUー18006株の伝播性,免疫原性ならびにブ-スタ-接種効果に関する検討" 臨床とウイルス. 18. 102-114 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shozo Urasawa et al: "Survey of human rotavirus serotypes in different locales in Japan by ELISA with monoclonal antibodies." Rinsho to uirusu. 17. 132-136 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noriaki Adachi et al: "Transmissibility and immunogenicity of the rhesus rotavirus vaccine MMU-18006." Igakunoayumi. 151. 67-68 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shozo Urasawa et al: "Survey of human rotavirus serotypes in different locales in Japan by ELISA with monoclonal antibodies." J. Infect. Dis. 160. 44-51 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Niriaki Adachi: "Transmissibility, immunogenicity and booster effect of rhesus rotavirus vaccine MMU-18006." Rinsho to uirusu. 18. 102-114 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 浦沢正三: "本邦7地域における下痢症患者便中ヒトロタウイルスの血清型別試験成績" 臨床とウイルス. 17. 132-136 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 足立憲昭: "サル由来ロタウイルスワクチンMMU-18006株の伝播性および免疫原性に関する研究" 医学のあゆみ. 151. 67-68 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 足立憲昭: "ロタウイルスワクチンMMU-18006株の伝播性、免疫原性ならびにブ-スタ-接種効果に関する検討" 臨床とウイルス. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Urasawa,S.: "Survey of human rotavirus serotypes in different locales in Japan by ELISA with monoclonal antibodies" J.infect.Dis.160. 44-51 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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