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Role of cytokines produced by epidermal keratinocytes

Research Project

Project/Area Number 01570558
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTeikyo University (1991)
Tohoku University (1989-1990)

Principal Investigator

TAKEMATSU Hideaki  Teikyo University, Dep of Med, Assoc*, 医学部, 助教授 (80124600)

Co-Investigator(Kenkyū-buntansha) 只木 行敬  東北大学, 医学部附属病院, 助手 (40188256)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordskeratinocytes / cytokines / inflammation / 炎症性皮膚疾患
Research Abstract

Cytokine IL-8 has been purified from psoriatic scales. Its leukotactic activity as well as the presence in psoriatic scales suggests a role in the pathogenesis of psoriasis. The purpose of this study was to investigate the contribution of leukotactic IL-8 as well as complement-derived C5a in the transepidermal leukocyte migration in psoriatic skin. We have carried out quantification of the levels of IL-8 in the suction billister fluids as well as chemotactic activity, IL-8, and C5a/C5a des Arg levels in the scale extracts from proriatic skin. The levels of IL-8 in the suction blister fluids from psoriatic lesional skin were significantly higher than those from normal and proriatic univoloved skin. The chemotactic activities of psoriasis vulgaris, erythrodermic psoriasisis, and pustular psoiasis were significantly higer than those of non-psoriatic hyperkeratotic skin. The IL-8 levels in tehorny tissue extacts of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis were signfificantly higer than those of controls. The C5a/C5ades Arg levels in the scale extracts of psoriasis vulgaris, pustrular psoriasis, and pustulosis palmaris et plantaris were also significantly elevated when compared with those of controls. A positive correlation was found between the concentrations of C5a/C5a des Arg and neutrophil chemotactic activities in the horny tissue extracts. Thus, in psoriasis the acitivation of complemnt is a closely relatd to accumulation of leukocytes in the lesional skin, and IL-8 may actsynergistically with complement-derived C5a in the local immune responses by recruiting leukocytes within the sites of inflammation.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 竹松 英明,田上 八朗: "TNFによる乾癬の治療" 臨床免疫. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明: "乾癬とアラキドン酸代謝物" 日本皮膚科学会雑誌. 101. 1707-1710 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明,田上 八朗: "乾癬に対するシクロスポリンの長期投与" 西日本皮膚科. 52. 1046-1050 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明,佐々木 由美子: "好酸球性膿疱性毛嚢炎" 臨床皮膚科. 43. 543-546 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明ほか: "シクロスポリンによる難治性乾癬の治療" 臨床皮膚科. 43. 425-427 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明ほか: "乾癬表皮中に認められたヒストン依存性蛋白リン酸化酵素" 日本皮膚科学会雑誌. 99. 1345-1346 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takematsu H, Tagami H: "Complement fragment C4d and Bb levels in inflammatory skin diseased (e. g. SLE, atopic dermatitis. erythroderma and pustulosis palmaris et plantaris (for assessment of complement activation" Tohoku J Exp Med. 163. 263-268 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takematsu H, Tagami H: "Detection of released CD4 and CD8 antigens in the suction-blister fluid and horny-tissue extract in patients with psoriasis" Br J Dermatol. 124. 550-554 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 竹松 英明,田上 八朗: "TNFによる乾癬の治療" 臨床免疫. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 竹松 英明: "乾癬とアラキドン酸代謝物" 日本皮膚科学会雑誌. 101. 1707-1710 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 竹松 英明,田上 八朗: "乾癬に対するシクロスポリンの長期投与" 西日本皮膚科. 52. 1046-1050 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 竹松 英明,佐々木 由美子: "好酸球性膿疾毛襄炎" 臨床皮膚科. 43. 543-546 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 竹松 英明ほか: "シクロスポリンによる難治性乾癬の治療" 臨床皮膚科. 43. 425-427 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 竹松 英明 ほか: "乾癬表皮中に認めくれたヒストン依存性蛋白リン酸化酵素" 日本皮膚科学雑誌. 99. 1345-1346 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takematsu,H,Isono,N,Kato,T,Tagami,H: "Normal human epidermal keratinocyteーderived neutvophil chemotactic factor" Tohoku J Evp Med. 162. 1-13 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Takematsu & H.Tagami: "Assessment of the activation pathways of the complement in psoriatic patients by use of complement fragment C4d and Bd measurements" Dermatologica. 179. 16-19 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Takematsu et al.: "Psoriatic lesions do not respond to oral administration of Lobenzarit disodium,an inhibitor of interleukin l production" Dermatologica. 179. 64-66 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Takematsu et al.: "Absence of tumor necrosis factor-a in suction blister fluids and stratum corneum from patients with psoriasis" Arch Dermatol Res. 281. 398-400 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Takematsu & H.Tagami: "Pressing and stretching of psoriatic lesions induce their involution" Acta Derm-Venereol. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Takematsu & H.Tagami: "Interleukin 2,interleukin 2 receptor and interferon-r in the suction blister fluids from psoriatic skin" Arch Dermatol Res. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Takematsu & H.Tagami: "Granulocyte-macrophage colony-stimulating factor in psoriasis" Dermatologica. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2019-02-28  

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