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Survey of prognosis of dermatomyositis

Research Project

Project/Area Number 01570579
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTokyo Women's Medical University

Principal Investigator

HIDANO Akira  Tokyo Women's Medical College, The Medicine faculuty, Professor, 医学部, 教授 (00075178)

Co-Investigator(Kenkyū-buntansha) ISHIGURO Naoko  Tokyo Women's Medical College, The Medicine faculty, Assistant, 医学部, 助手 (30198519)
TORIKAI Sayori  Tokyo Women's Medical College, The Medicine faculty, Assistant, 医学部, 助手 (90200550)
HIGAKI Yuuko  Tokyo Women's Medical College, The Medicine faculty, Assistant, 医学部, 助手 (80189745)
UEMURA Tomoko  Tokyo Women's Medical College, The Medicine faculty, Assistant, 医学部, 助手 (10203481)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
Keywordsdermatomyositis / prognosis / complication / internal malignancy / interstitial pneumonitis / childhood / overlap syngrome
Research Abstract

We sent, in 1990, questionnaires to the major dermatological institutions in Japan concerning the course and associations of dermatomyositi-s and could obtain responses from 186 institutions. We analysed the total 237 cases (182 cases following the criteria of Bohan & Peter, definite or probable dermatomyositis) diagnosed by dermatologists from Jan. 1983 to Dec-1987. In 17 children, no case died, , In adults, 44 cases (26.7*) died : the causes of death were attributed to malignancies (16 cases), interstitial pneumonitis (13 cases), other pneumonia (4 cases), and so on. The associated malignancies were gastric cancer, lung cancer, breast cancer and so on. -Therewas only-a case of malignant lymphoma. The mortality due to cancer was 34.0%. Periungual erythema and dysphagia were more frequently associated in cancer group (p<0.01). Pruritus and poikiloderma were more frequently noted in cancer group (p<0.05). Interstitial pneumonitis (IP) was associated in 31 cases after the age of 30, and 13 of them died of pneumonitis : the majority died within 6 months after the diagnosis of dermatomyositis. Skin ulcer and arthralgia were more frequently noted in the IP group, while pruritus was less frequently associated (p<0.01). No serum examination was statistically different between the IP and non-IP group, but upper dermal edema in skin biopsy was more frequently noted in the IP group. Thus, we could obtain some predictive factors for the vital prognosis of dermatomyositis. In contrast, the association of cancer in systemic lupus. erythematosus in our department was only 3 cases (6.8%) out of 44 cases much lower than the incidence (30.1%) in adult dermatomyositis.

Report

(3 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] A.Hideno,S.Torikai,T.Uemura,S.Shimizu: "Malignancy and interstitial pneumonitis as fatal complications in dermatomyositis." The Journal of Dermatology (Tokyo). 19. 153-160 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鳥飼 抄順,上村 知子,肥田野 信,清水 悟: "間質性肺炎を伴った皮膚筋炎の予後調査" 臨床皮膚科. 46. 37-40 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鳥飼 抄順,上村 知子,肥田野 信: "アンケ-トによる小児皮膚筋炎の調査" 日本小児皮膚科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Hidano, S. Torikai, T. Uemura, S. Shimizu.: "Malignancy and interstitial pneumonitis as fatal complications in dermatomyositis." The Journal of Dermatology. 19-3. 153-160 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Torikai, T. Uemura, A. Hidano, S. Shimizu.: "Prognosis of dermatomyosits with interstitial pneumonitis." Rinsho Hifuka. 46-1. 37-40 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Torikai, T. Uemura, A. Hidano, S. Shimuzu.: "Prognosis of childnood deramatomyositis by questionaire." Jpn J Ped Dermatol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A.Hidano,S.Torikai,T.Uemura,S.Shimizu: "Malignancy and interstitial pneumonitis as fatal complications in dermatomyositis." Archives of Dermatology (Chicago). 127(10). (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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