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A Study for Optimization in Brachytherapy-Volume-Dose Relationship and Relating Biologic Factors-

Research Project

Project/Area Number 01570584
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNippon Medical School (1990)
Tokyo Medical and Dental University (1989)

Principal Investigator

HORIUCHI Junichi  School of Medicine, Nippon Medical School, professor, 医学部 (90013870)

Co-Investigator(Kenkyū-buntansha) SHIBUYA Hitoshi  School of Medicine, Tokyo Medical and Dental University associate professor, 医学部, 助教授 (10014292)
竹田 正宗  東京医科歯科大学, 医学部, 助手 (30014244)
松本 悟  東京医科歯科大学, 医学部, 助手 (10209629)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsbrachytherapy / volume-dose factor / optimization, / dose distribution / 容積、線量関係 / Ir-192線源 / 放射線治療
Research Abstract

Introduction of recent afterloading source of Ir-192 (Ir) was successfully decreased undue exposure for medical staff. Treatment results of Ir was obtained equivalent to Radium (Ra) for similar stage of patients, but, late damage was more frequent in Ir group. In order to clarify the optimization of brachytherapy, discriminant analysis based on a volume-dose relationship was examined for tongue cancer patients with Ir. From discriminant analysis of volume-dose histogram (VDH), there was apparent difference between Ir and Ra. Main difference was shape of VDH, concentrating along the peak of modedose with sharp slope in lr group compared to blunt one in Ra. These results demonstrated that stability in source arrangement seemed to be superior in Ir source as the source could be introduced through non-radioactive guide-gutter, and this was compatible to dose distribution of Ir source. As the effective dose distance from the implanted plane in Ir was thin compared to Ra, clinical application of Ir single implant was suitable for rather superficial lesion. Frequent late damage in Ir group seemed to be based on high cumulative volume rate (CVR) which received doses higher than 70Gy. In the case of Ir implant alone, mandibular damage could be markedly decreased with specially made dental guard.
While, in the case of combined external beam irradiation with brachytherapy, higher complication was observed ; as the contribution of external beam was arranged to small as possible, the analysis of VDH was rather difficult, but, some threshold dose must be considered among the stage of the primary lesion.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report

Research Products

(18 results)

All Other

All Publications (18 results)

  • [Publications] Masao Hoshina et al.: "Discriminant analysis on the treatment results of interstitial radium tongue implants." Brit.J.Radiology. 62. 59-63 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一: "口腔悪性腫瘍の放射線治療" 日本口腔外科学会雑誌. 35. 1682-1686 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一: "頭顎部癌の放射線治療" 医学のあゆみ. 150. 953-958 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一ほか: "低線量為TAO式腔内照射による子官顎癌の放射線治療成績" 臨床放射線. 34. 1483-1486 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shigemasa Hisamitsu: "Prognostic factors in head and neck nonーHodgkin's lymphoma with special reference to serumlactic dehydrogenase and serum copper." Acta Oncologicチ. 29. 879-883 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Junichi Horiuchi et al.: "Usefulness of AA198BB Au grain implants in the treatment of oraland oropharyngeal cancer." RADIOTHERAPY and Oncology. 20. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一: "癌治療学:口腔癌 放射線療法" 日本臨床社, 7 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一: "癌治療学:咽頭癌 放射線療法" 日本臨床社, 7 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masao Hoshina et al.: "Discriminant analysis on the treatment results of interstitial radium tongue implants." Brit. J. Radiology. 63. 59-63 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Junichi Horiuchi et al.: "Carcinoma of uterine cervix treated with TAO low-dose rate intracavitary radiation." Jpn. J. Clin. Radiol.34. 1483-1486 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Junichi Horiuchi: "Radiation therapy for head and neck cancer." Igaku no Ayumi. 150. 953-958 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Junichi, Horiuchi: "Treatment of tongue cancer with special emphasis on radiotherapy" Karkinos. 3. 371-378 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shigemasa Hisamitsu et al.: "Prognostic factors in head and neck non-Hodgkin's lymphoma with special reference to serum lactic dehydrogenase and serum copper." Acta Oncologica. 29. 879-883 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Junichi Horiuchi et al.: "Usefulness of ^<198> Au grain implants in the treatment of oral and oropharyngeal cancer." Radiotherapy and Oncology. 20. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堀内 淳一: "口腔癌一治療方針とその選択ー放射称治療の立場からー" JOHNS. 6. 207-212 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 堀内 淳一: "舌癌の治療ー放射線治療を中心として." KARKINOS. 3. 371-378 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shigemasa Hisamitsu: "Prognostic factors in head and neck nonーHodgkin´s lymphoma with special reference to serumlactic dehydrogenase and serum copper." Acta Oncologica. 29. 879-883 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Junichi Horichi et al.: "Usefulness of^<198> Au grain implants in the treatment of oral and oropharyngeal cancer." RADIOTHERAPY and Oncology. 20. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1989-03-31   Modified: 2016-04-21  

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