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MR (Magnetic Resonance) Evaluation of Bone Marrow Dynamics in Hematological Disorders

Research Project

Project/Area Number 01570594
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionSaitama Medical School

Principal Investigator

HESHIKI Atsuko  Saitama Medical School Department of Radiology Professor and Chairman, 医学部, 教授 (60008589)

Co-Investigator(Kenkyū-buntansha) HIRASHIMA Kunitake  Saitama Medical School Department of 1st Internal Medicine Professor and Chairma, 医学部, 教授 (00165169)
朝日 良一  埼玉医科大学, 放射線科, 講師
西村 克之  埼玉医科大学, 放射線科, 助教授 (10129158)
隣谷 義人  埼玉医科大学, 放射線科, 教授 (50049780)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
KeywordsBone Marrow MRI / STIR / Myelodysplastic Syndrome / Multiple Myeloma / Aplastic Anemia / Chronic Myelogenous Leukemia / STIR with Double Echo / Myelodysplastic Syndrome / MRI / 骨髄 / 血液疾患 / MDS
Research Abstract

l. Normal Bone Marrow MRI
(1) Optimal Pulse Sequences ; The optimal pulse sequences to image in vivo bone marrow dynamics were STIR with double echo ; TR ; 2000sec, TI 160msec. and TE 20msec. for STIR with shortTE and 120 msec. for longTE.
(2) Normal Bone Marrow MRI ; , STIR with short TE disclosed normal mid-sagittal lumbar vertbrae to be high signal in the peripheral portion of the vertbrae and low signal in the center. The high signal corresponds to red marrow and low signal to yellow marrow. The fatty degeneration took place from lower lumbar vertbra and-ascended cephalad direction.
2. Abnormal Bone Marrow MRI
Eighty-four MRI in various hematological disorders were obtained with STIR with short and long TE. Aplastic anemia showed completely low signal with STIR with short TE in 80%. Multiple myeloma, Chronic myelogenous leukemia, Myelodysplastic syndrome and Myelofibrosis revealed either homogeneous or hetrogeneous high signals with STIR with short TE, while their signals decayed with STIR with long TE in Cronic myelogenous leukemia. STIR with short TE highlights water component and STIR with long TE enhances water T2 component.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 平敷 淳子: "外科におけるMRIの現況 骨・軟部組織" 外科療. 32. 56-59 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 平敷 淳子: "関節疾患とMRIー綜説ー" 外節外科. 9. 41-45 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 天沼 誠: "四肢・骨髄疾患" 臨床画像. 7. 192-203 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 平敷 淳子: "血液疾患の画像診断" 朝倉書店, 520 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 水野 ひとみ: "夛発性骨髄腫のMRI" 金原出版, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Atsuko HESHIKI: "Current status of MRI in Surgery---Bone and Soft Tissue" Gekashinryo. 32. 56-59 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Atsuko HESHIKI: "MRI of Joint Diseases ----Overview-----" Kansetsu-Geka. 9. 41-45 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Makoto AMANUMA: "Diseases of Extremities and Bone Marrow" Rinsho-Gazou. 7. 192-203 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitomi MIZUNO: "Bone Marrow Imaging in Hematological Disorders" Journal of Magnetic Resonance Imaging. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitomi MIZUNO: "How to read---Soft Tissue----" Iyaku Journal. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Atsuko HESHIKI: "Imaging Diagnosis of Hematological disorders" Asakura-Shoten. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitomi MIZUNO: "MRI of Multiple Myeloma" Kanehara-Shuppan. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 平敷 淳子: "外科におけるMRIの現況 骨・軟部組織" 外科診療. 32. 56-59 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 平敷 淳子: "関節疾患とMRI 総説" 関節外科. 9. 41-45 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 天沼 誠: "四肢・骨髄疾患" 臨床画像. 7. 192-203 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hitomi MIZUNO: "Bone Marrow Imaging in Hematological DisordersーーーSTIRーーーー" Journal of Magnetic Resonance Imaging. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 平敷 淳子: "血液疾患の画像診断" 朝倉書店, 250 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 水野 ひとみ: "夛発性骨髄腫のMRI" 金原出版, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 平敷 淳子: "外科におけるMRIの現況 骨・軟部組織" 外科診療. 32. 56-59 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 平敷 淳子: "関節疾患とMRI 総説" 関節外科. 9. 41-45 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 平敷 淳子 平嶋 邦猛: "血液疾患の画像診断" 朝倉書店, 150 (1992)

    • Related Report
      1990 Annual Research Report
  • [Publications] 平敷淳子: "外科におけるMRIの現況 骨・軟部組織" 外科診療. 32. 56-59 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 平敷淳子: "間接疾患とMRI総説" 間接外科. 9. 41-45 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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