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Study on intratumoral injection of drugs combined with hyperthermia and radiation for cacer

Research Project

Project/Area Number 01570596
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTokai University

Principal Investigator

OHIZUMI Yukio  Tokai University, School of Medicine, Lecturer, 医学部, 講師 (30024813)

Co-Investigator(Kenkyū-buntansha) FUKUHARA Noboru  Tokai University, School of Medicine, Assistant, 医学部, 助手 (70218949)
TAMAI Yoshifumi  Tokai University, School of Medicine, Assistant, 医学部, 助手 (90207225)
OHIZUMI Yukio  Tokai University, School of Medicine, Lecturer (30024813)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
KeywordsRadiation / Hyperthermia / Resistant tumor / Anti-cancer drugs / Epinephrine / Intratumoral injection / Lewis lung carcinoma / Drug delivery system / ドラッグ デリバリ- システム / 薬剤
Research Abstract

1. Effects of anti-cancer, drugs injected intratumorally (i. t.) : Anti-cancer drugs injected i. t. had higher effect on growth inhibition and lower complication than the drugs injected i. p. Also, the drugs injected i. t. inhibited lung metastages as well as i. p.
2. Relationship between tumor blood flow, intratumoral concentration of radiosensitizer and radiosensitizing effect : Measurement of the drug concentration showed poor distribution and rapid disappearance of drugs injected i. t. . The drug disappearance rate was related inversely to tumor blood flow. Subcutaneous tumors, which had poorer blood flow than intramuscle tumors, were sensitized remarkably by i. t. injection of radiosensitizer. Drug distribution in the tumor was different between i. t. and i. p. injection and large effect was obtained by the-two rutes of administration.
3. Heat-sensitizing effect by intratumoral drugs : DWA2114R, PEP, BLM, and MMC enhanced hyperthermic effect among anti-cancer drugs. Little enhancement was observed in other drugs, except for epinephrine which sensitized remarkably hyperthermic effect depending on the concentration of drug and temperature. It was considered to be due to iillerceller environment, perhapse low PH, induced by epinephrine.
4. Epinephrine and anti-cancer drugs injected i. t. . : Epinephrine also sensitized the effect of DWA2114R, PEP and MMC, but protected the effect of SMANCS and radiation. This is considered to be due to the drug concentration and interceller enbironment modified by epinephrine.
5. Combining effect of hyperthermia and intratumoral epinephrine and anti-cancer drugs : These combination had remarkable effect. This method seemed to be useful in clinical, because high effect was obtained by low dose of drug and mild temperature.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Yukio OHIZUMI: "Combined effects on tumor growth and lung metastases in Lewis lung carcinoma treated by hyperthermia and intratumoral injection of anti-caner drugs." Int.J.Hyperthermia.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "エピネフリンの腫瘍内投与による温熱効果の増強" 日本ハイパ-サ-ミア誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "エピネフリンの局所投与による温熱増強効果ー投与法の検討" 日本ハイパ-サ-ミア誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "放射線増感剤の腫瘍内投与法に関する基礎的研究" 日本放射線腫瘍学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "エピネフリンによる腫瘍内投与された抗癌剤の効果増強について" Drug Delivery System.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "抗癌剤とエピネフリンの腫瘍内投与と温熱との併用効果" 日本医学放射線学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "腫瘍内増感剤の基礎的研究ー血流と腫瘍内増感剤濃度の関係" 日本医学放射線学会生物部会誌. 3. 84-86 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "ルイス肺癌における局所温熱による肺転移についての再検討" 日本ハイパ-サ-ミア学会誌. 7. 23-32 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "局所温熱と抗癌剤(塩酸アクラルビシン,DWA2114R)併用時における移植ルイス肺癌の成長と肺転移に及ぼす影響について" 日本ハイパ-サ-ミア学会誌. 7. 33-41 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "ルイス肺癌における腫瘍内薬剤投与による抗腫瘍効果と転移に及ぼす影響" Drug Delivery System. 6. 449-453 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大泉 幸雄: "腫瘍内増感剤投与時の放射線増感効果" 日本医学放射線学会生物会誌. 4. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Sato. C., Imamiya, S. et al.: "Study on intratumoral administration of hypoxic radiosensitizer - Relationship between tumor blood flow and intratumoral concentration of the drug." Nippon Act. Radiol. Seibutsu bukaishi. 3. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Imamiya, S., Maezawa, H., et al.: "Re-evaluation on lung metastases by local hyperthermia in Lewis lung carcinoma." Jpn. J. Hyperthermic Oncol.7. 23-32 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Imamiya, S., Maezawa, H., et al.: "Effect of aniticancer drugs (Aclarubicin hydrochloride, DWA2114R) combined with local hyperthermia on growth and metastasis of Lewis lung carcinoma." Jpn. J. Hyperthermic Oncol.7. 33-41 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Imamiya, S., and Mori, T.: "Effects of Intratumoral drug injection on tumor growth and lung metastases in Lewis lung carcinoma." Drug Delivery system. 6. 449-453 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Shoji, T., Imamiya, S. et al.: "Radiosensitizing effect of hypoxic radiosensitizer administered intratumorally." Nippon Act. Radiol. Seibutsu bukaishi.4. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Imamiya, S., Maezawa, H. et al.: "Combined effects on tumor growth and lung metastases in Lewis lung carcinoma treated by hyperthermia and intratumoral injection of anti-cancer drugs(Aclarubicin, DMA2114R, Peplomycin)." Int J Hyperthermia.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Maezawa, H., and Mori, T. et al.: "Heat-sensitizing effect of epinephrine injected intratumorally." Jpn. J. Hypertheric Oncol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Maezawa, H., and Mori, T. et al.: "Heat-sensitizing effect of epinephrine injected locally-Study on administration of epinephrine." Jpn. J. Hypertheric Oncol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Shoji, H., Mori, T. et al.: "Study on intratumoral administration of hypoxic radiosensitizer." J. Jpn. soc. Ther. Radiol. Oncol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Shoji, H., Maezawa, H. et al.: "Modifying effect of anti-cancer drugs injected intratumorrally with epinephrine." Drug Delivery system.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohizumi, Y., Imamiya, S., Maezawa, H. et al.: "Combining effect of hyperthermia and intratumoral injection of epinephrine and anticancer drugs on tumor growth inhibition of Lewis lung carcinoma." Nippon Act. Radiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yukio OHIZUMI: "Combined effects on tumor growth and lung metastases in Lewis lung carcinoma treated by hyperthermia and intratumoral injection of antiーcancer drugs." Int.J.Hyperthermia.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "エピネフリンの腫瘍内投与による温熱効果の増強" 日本ハイパ-サ-ミア誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "エピネフリンの局所投与による温熱増強効果ー投与法の検討" 日本ハイパ-サ-ミア誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "放射線増感剤の腫瘍内投与法に関する基礎的研究" 日本放射腫瘍学会誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "エピネフリンによる腫瘍内投与された抗癌剤の効果増強について" Drug Delivery System.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "抗癌剤とエピネフリンの腫瘍内投与と温熱との併用効果" 日本医学剤射線学会誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "腫瘍内増感剤の基礎的研究ー血流と腫瘍内増感剤濃度の関係" 日本医学放射線学会 生物部会誌. 3. 84-86 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "ルイス肺癌における局所温熱による肺移についての再検討" 日本ハイパ-サ-ミア学会誌. 7. 23-32 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "局所温熱と抗癌剤(塩酸アクラルビシン,DWA21114R)併用時における移植ルイス肺癌の成長と肺転移に及ぼす影響について" 日本ハイパ-サ-ミア学会誌. 7. 33-41 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "ルイス肺癌における腫瘍内薬剤投与による抗腫瘍効果に転移に及ぼす影響" Drug Delivery System. 6. 449-453 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "腫瘍内増感剤投与時の放射線増感効果" 日本医学放射線学会 生物部会誌. 4. (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大泉 幸雄: "腫瘍内増感剤の基礎的研究 ー血流と腫瘍内増感剤濃度の関係" 日本医学放射線学会 生物部会誌. 3. 84-86 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大泉 幸雄: "ルイス肺癌における局所温熱による肺転移についての再検討" 日本ハイパ-サ-ミア学会誌. 7. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大泉 幸雄: "局所温熱と抗癌剤(塩酸アクラルビシン,DWA2114R)併用時における移植ルイス肺癌の成長と肺転移に及ぼす影響について" 日本ハイパ-サ-ミア学会誌. 7. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大泉 幸雄: "ルイス肺癌における腫瘍内薬剤投与による抗腫瘍効果と移転に及ぼす影響" Drug Delivery System.

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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