| Co-Investigator(Kenkyū-buntansha) |
MURATA K. Aichi Medical University, Dep. of radiology, Lecturer, 医学部, 講師 (90148338)
HAYASHI T. Aichi Medical University, Dep. of Psychiatry, Lecturer, 医学部, 講師 (80173011)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
The brain morphological and/or functional differences between typical schizophrenia and atypical psychosis (ATP) were identified by means of brain imaging techniques.
On CT scan studies, schizophrenics had significant enlargement of interhemispheric fissure, lateral and 3rd ventricle, and sylvian fissures (SF), while ATP patients had only significantly enlarged SFs, especially on the right side. Furthermore, a certain group of schizophrenics showed significantly higher density in the frontal regions and the head of caudate nucleus in contrast to ATP patients. On early image by ^<123>I-IMP SPECT, the schizophrenics showed significantly decreased uptake rates in the bilateral frontal regions, whereas, the ATP patients did so in the right basal ganglia. On late image, the schizophrenics displayed significantly decreased uptake rate not only in frontal region, but also in left occipital and basal ganglia regions. On the contrary, the ATP patients had no findings in any region.
By cluster analysis of brain CT data, typical schizophrenia ATP tend to be grouped differently. The two groups with either interhemispheric fissure or left SF enlargement consisted mainly of schizophrenics. Another group, which had right SF enlargement and demonstrated more frequent family histories, comprised mainly ATP patients and paranoid-type schizophrenics. In fact, a considerable number of patients had no significant abnormal CT findings, suggesting that both psychoses are still heterogeneous and that further subclassification is warranted.
As for ATP, our data indicate that a group of ATP patients with family histories might have functional disorders in right basal ganglia, and frequent recurrence might eventually result in right SF enlargement.
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