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A Study of Anastomotic Neointimal Hyperplasia After Graft Inplantation.

Research Project

Project/Area Number 01570699
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHokkaido University

Principal Investigator

SAKUMA Makoto  Hokkaido University School of Medicine, (Surgery) Assistant, 医学部附属病院, 助手 (70170636)

Co-Investigator(Kenkyū-buntansha) TANABE Tatuzo  Hokkaido University School of Medicine, (Surgery) Professor, 医学部, 教授 (50000956)
YASUDA Keisyu  Hokkaido University School of Medicine, (Surgery) Asspcoate Professor, 医学部附属病院, 助教授 (60125359)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsAnastomotic neointimal hyperplasia / Vascular prosthesis / Arterial reconstructive surgery / Graft obstruction / Platelet scintigraphy / anastomotic neointimal hyperplasia
Research Abstract

Despite improvement of the vascular prostheses, the long term patency rate remains unfulfilled after small caliver graft implantation. Anastomotic neointimal hyperplasia (ANH) is known as a contributing factor of graft occlusion after implantation and the difference of mechanical properties between a vascular prosthesis and its host arteries, abnormal graft flow, intimal trauma due to surgical procedure, platelet aggregation in a surface of anastomotic site, suture material and method are suggested the factors of ANH.
In this study, we investigated (1) the difference of mechanical properties between vascular grafts and host arteries. (2) small caliber(3mm in diameter) graft implantation in dogs and long term observation of the anastomotic site after implantation. (3) comparison of thrombogenecity of grafts and ANH. The results are as follows ;
(1) A new type ultrasonic displacement meter was developed and compliance of arterial grafts ware measured. In comparison of compliance of human a … More rteries to that of grafts, a mismatch in compliance between grafts and arteries was obviously demonstrated.
(2) In dogs, carotid artery was replaced with different compliance of graft (ePTFE, segmented polyurethane graft) 3mm in diameter and long term observation was performed. The rate of patency was good in high compliance graft (50%/1 year) but ANH was occurred both in low compliance graft and high compliant graft. Compliance mismatch between vascular prosthesis and host arteries is suggested to be one of the factor contributing ANH, but it seems to be not a main factor.
(3) To evaluate relationship between platelet aggregation in a surface of graft and ANH. In^<111> platelet scintigraphy was performed in the early and late stage of graft implantation. There was significant difference of the patency rate between high platelet aggregation group and low plate let aggregation group in the early stage after implantation but there was no difference of occurrence of ANH between the two groups. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 佐久間 まこと,他: "血行再建の遠隔開存を阻止する因子とその対策一晩期閉塞因子の解析" 脈管学. 29. 1150-1153 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐久間 まこと,他: "理想的人工血管開発へのアプロ-チー抗血栓性と弾性特性からみた人工血管の性能評価" 人工臓器. 19. 1056-1059 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐久間 まこと,他: "閉塞性動脈硬化症の治療" 現代医療. 22. 1602-1606 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐久間 まこと,他: "新しい人工血管の開発" 脈管学.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐久間 まこと,他: "血管吻合部内膜肥厚の発生機序と予防" 脈管学.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Makoto Skuma, Keisyu Yasuda, and Tatuzo Tanabe: "An Analysis of Factors Interrupting Long Term Patency of Bypass Graft after Arterial Reconstruction." Myakkan-Gaku, The Journal of Japanese College of Angiology. Vol 29. 1150-1153 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Makoto Satuma, Keisyu Yasuda, and Tatsuzo Tanabe: "An Approach to Development of the Ideal Vascular Prostheses." Japan Journal of Artificial Organ. Vol 19. 1056-1059 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Makoto Sakuma, Keisyu Yasuda, and Tatsuzo Tanabe: "Treatment of Arteriosclerosis Obliterance" Gendai Iryo. Vol 22. 1602-1606 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Makoto Saguma, Keisyu Yasuda, Toshiya Nisibe, Keisyu Yasuda, and Tatsuzo Tanabe: "Development of New Vascular Prostheses" Myakkan-Gaku. The Journal of Japanese College of Angiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Makoto Sakuma, Toshiya Nishibe, Keisyu Yasuda. and Tatsuzo Tanabe: "Mechanisms of Anastomotic Neointimal Hyperplasia" Myakkan-Gaku, The Journal of Japanese College of Angiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐久間 まこと,他: "血行再建の遠隔開存を阻止する因子とその対策ー晩期閉塞因子の解析" 脈管学. 29. 1150-1153 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間 まこと,他: "理想的人工血管開発へのアプロ-チー抗血栓性と弾性特性からみた人工血管の性能評価" 人工臓器. 19. 1056-1059 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間 まこと,他: "閉塞性動脈硬化症の治療" 現代医療. 22. 1602-1606 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間 まこと,他: "新しい人工血管の開発" 脈管学.

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間 まこと,他: "血管吻合部内膜肥厚の発生機序と予防" 脈管学.

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間まこと,安田慶秀,田辺達三: "血行再建の遠隔開存を阻止する因子とその対策-晩期閉塞因子の分析" 脈管学. 29. 1151-1153 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 佐久間まこと,安田慶秀,田辺達三: "Axillo-femoral bypass" 手術. 43. 1455-1462 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田辺達三,安田慶秀,佐久間まこと 他: "血行再建における新しい展開" 外科治療. 61. 297-299 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 安田慶秀,田辺達三: "人工血管の進歩" 外科診療. 31. 433-437 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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