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RESEARCH FOR SENSITIVITY SCREENING TEST OF BIOLOGICAL RESPONSE MODIFIERS TO TREAT CANCER PATIENTS

Research Project

Project/Area Number 01570758
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

GOCHI Akira  OKAYAMA UNIVERSITY ATTACHED HOSPITAL ASSISTANT, 医学部附属病院, 助手 (10186877)

Co-Investigator(Kenkyū-buntansha) FUCHIMOTO Sadanori  OKAYAMA UNIVERSITY ATTACHED HOSPITAL LECTURER, 医学部附属病院, 講師 (60144771)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
KeywordsBIOLOGICAL RESPONSE MODIFIERS / SENSITIVITY SCREENING / IMMUNOLOGICAL PARAMETER / TH1 AND TH2 BALANCE / HLA CLASS 1 ANTIGEN / INDIVIDUALIZATION OF THERAPY / Biological responce modifier / 免疫パラメ-タ / 免疫抑制物質 / BRM / 至適パラメ-タ / 皮内反応 / 宿主要因 / biological responce modifier / パラメ-タ / HLA / cytokine
Research Abstract

Immunotherapy was thought one of miraculous therapy for cancer patients.
Too many biological response modifiers (BRMs) has been used for post operative adjuvant chemotheraph in Japan reason for less adverse effectof these agents. Nevertheless, recently, these therapy agents have been reevaluated scince 1989. Some reports douted the efficasy of these agents were published. On the otherhand, many researchers gradually clarified the mechanisms of BRMs. Our randomized control study used these BRMs were not obtained advantage ous results. But subsets analysis of these trials reveals the advantage of therapy used BRMs. In these results, It showes the nessesity of the selection ofresponder for BRMs therapy same as sensitivity test of anti-biotics.
We tried to select which is the more useful in the conventional immunological parameters, for example, number of lymphocyte, blasted ratio of lymphocyte, skin test, nutritional index and so on. None of these parameters useful to select the responder before treatment. But, the alterlation of these parameters during the therapy were useful for selection of the responder. Our analysis shows that some subtypes of HLA class 1 antigen will be one of the useful sensitive screening parameter for lentinan therapy. Recently, it is emphacized that Th1 and Th2 balance is important factor for cancer therapy. We examined the Th1 and Th2 balance with cytokine production assay of whole blood assaystimulated each BRMs. About one of third shifted from Th2 to Th1, another one third shifted from Th1 to Th2 in each assay system. These results show that each BRMs have been selected according to the state of immunopotencity of patients.
In this study, we propose the candidate of sensitivity screening of BRMs such as HLA class 1 antigen, the alterlation of conventional immunological parameters and evaluation of Th1-Th2 balance due to cytokine assay.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] AKIRA GOCHI KUNZOU ORITA et al.: "Reduction of Lymph node(LN)metastasis and improvement of survival by preoperative endoscopic intratumoral (IT)injection of OK=432",streptococal preparation,in gastric cancer patients." Frontiers of Mucosal Immunology. 2. 453-456 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 折田 薫三、合地 明: "BRM治療における宿主要因の重要性" Ther.Res.11. 232-244 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 合地 明、渕本 定儀 他: "OK-432術前経内視鏡的腫瘍内投与の意義と感受性スクリーニングの可能性" Ther.Res.11. 394-402 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 中山 文夫、合地 明 他: "胃癌患者末梢血単核球のOK-432添加培養からみた癌患者の免疫能およびBRM感受性の検討" Biotherapy. 5. 852-854 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 中山 文夫、合地 明 他: "胃癌患者末梢血単核球のBRM添加培養からみたBRM感受性スクリーニングの可能性" Biotherapy. 5. 595-599 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 嶋村 廣視、合地 明 他: "全血アッセイを用いたBRM感受性試験の可能性" Biotherapy. 9. 644-599 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] AKIRA GOCHI,KUNZOU ORITA et al: "Reduction of lymph node (LN) metastasis and improvement of survival by preoperative endoscopic intratumoral (IT) injection of OK-432, streptococcal preparation, in gastric cancer patients" Frontiers of Mucosal Immunology. Vol.2. 453-456 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] KUNZOU ORITA,AKIRA GOCHI: "Importance of host immune responcibility on BRM therapy for cancer patients" Ther.Res.vol 11. 232-244 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] AKIRA GOCHI,SADANORI FUCHIMOTO: "Possivility of sensitive screening and efficasy of preoperative intratumoral injection of OK-432" Ther.Res.vol.11. 394-402 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] FUMIO NAKAYAMA,AKIRA GOCHI et al: "Research for sensitivity assay of BRMs and immunopotencity of cancer patient due to PBL assay added OK-432" Biotherapy. vol.5. 852-854 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] FUMIO NAKAYAMA,AKIRA GOCHI et al: "Possivility of sensitive screening for BRMs by PBL assay added BRMs" Biotherapy. vol.5. 595-599 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] HIROSHI SHIMAMURA,AKIRA GOCHI et al: "Possivility of sensitive screening test for BRMs by whole blood cell assay" Biotherapy. vol.9. 644-646 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 中山 文夫: "胃癌患者末梢血単核球のBRM添加培養からみたBRM感受性スクリ-ニングの可能性" BIOTHERAPY. 5. 595-599 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 中山 文夫: "胃癌患者末梢血単核球のOKー432添加培養からみた癌患者の免疫能およびBRM感受性の検討" BIOTHERAPY. 5. 852-854 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 合地 明: "HLAとOKー432感受性の関連についてー術前腫瘍投与症例から検討ー" BIOTHERAPY.

    • Related Report
      1991 Annual Research Report
  • [Publications] 中山 文夫: "胃癌患者末梢血単核球のOKー432添加培養からみた癌患者の免疫能およびBRM感受性の検討" Biotherapy.

    • Related Report
      1990 Annual Research Report
  • [Publications] 中山 文夫: "胃癌患者末梢血単核球のBRM添加培養からみたBRM感受性スクリ-ニングの可能性" Biotherapy.

    • Related Report
      1990 Annual Research Report
  • [Publications] 合地 明: "OKー432術前腫瘍内投与例の免疫パラメ-タからの検討" Biotherapy.

    • Related Report
      1990 Annual Research Report
  • [Publications] 合地 明: "術前OKー432投与経路別免疫パラメ-タにおよぼす効果" Biotherapy.

    • Related Report
      1990 Annual Research Report
  • [Publications] 合地明: "胃癌術前免疫療法としてのOK-432経内視鏡的腫瘍内投与の意義" 日本外科学会雑誌. 90. 1439-1442 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 折田薫三: "胃癌リンパ節転移に対するOK-432術前内視鏡的投与の意義" BIOTHERAPY. 4. 176-181 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 合地明: "OK-432の術前経内視鏡的腫瘍内投与の意義と感受性スクリ-ニングの可能性" Therapeutic Research. 11. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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