| Project/Area Number |
01570766
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | School of Medicine, Keio University |
|---|
Principal Investigator |
TSUZUKI Toshiharu School of Medicine Keio University Associate Professor, 医学部, 助教授 (80051192)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANABE Minoru School of Medicine Keio University instructor, 医学部, 助手 (50197513)
MIYAZAWA Mitsuo School of Medicine Keio University instructor, 医学部, 助手 (20200165)
ARAI Youmei School of Medicine Keio University instructor, 医学部, 助手 (30184261)
UEDA Masakazu School of Medicine Keio University instructor, 医学部, 助手 (50142419)
|
|---|
| Project Period (FY) |
1989 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | liver cirrhosis / liver resection / liver failure / functional reserve / 肝硬変併存肝癌 / 残存肝予定領域 |
|---|
| Research Abstract |
To select patients with sufficient functional reserve of the liver, we have preoperatively measured blood flow in the hepatic veins draining remnant liver and quantity of indocyanine green (ICG) removed in the remnant liver. We have refined this test by using a coronary sinus flow catheter, which is introduced through a internal jugular vein into the hepatic veins without difficulty.
Blood flow is measured by a thermistor which is contained in the catheter, and calculated by a personal computer. The test can be carried out with accuracy in a short time.
Between May 1988 and February 1991, 20 patients with a variety of diseases of the liver and biliary tract received this test and 10 of the 20 patients underwent liver resection.
Postoperatively, 3 of the 10 patients presented intractable ascites, signs of encephalophathy, and jandice of the total bilirubin level of more than 5 mg/dl. In these patients, blood flow in the hepatic vein draining remnant liver was less than 300 ml/min and quantity of ICG removed was less than 0.1 mg/ml. Thus, it is necessary to select candidates with better results than these levels.
|
