• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Antitumor Effects of Flutamide on Experimental Esophageal Carcinoma Induced by N-Amyl-N-Methylnitrosamine (AMN) in Rats

Research Project

Project/Area Number 01570768
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

KONDOH Yasumasa  Department of Surgery, Assistant Professor School of Medicine, Tokai University,, 医学部, 講師 (00130063)

Co-Investigator(Kenkyū-buntansha) OGOSHI Kyoji  Department of Surgery, Assistant Professor School of Medicine, Tokai University,, 医学部, 講師 (30112775)
MAKUUCHI Hiroyasu  Department of Surgery, Associate Professor School of Medicine, Tokai University,, 医学部, 助教授 (80095645)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsEsophageal Cancer / Androgen / AMN / Flutamide / Experimental Esophageal Cancer / 抗アンドロゲン剤 / AMN実験食道癌 / 去勢 / フルタミド / アンドロゲン受容体阻害剤 / 発癌率 / ホルモン療法
Research Abstract

It is known that the incidence of carcinoma of the esophagus in men is about four times higher than that in women, and the prognosis after resection of esophageal carcinoma is substantially better in women than it is in men. Human skin is one of the androgen target organs and the androgen binding capacity of human skin cytosol has been measured. Since the esophageal mucosa consists of squamous epithelium the same as human skin does, it was speculated that sex hormones, androgen in paticular, might play an important role in cell proliferation of the esophageal mucosa and in carcinogenesis. We have been investigating the possible effects of sex hormones on the carcinogenesis of esophageal carcinoma in rats that were given N-Amyl-N-methylnitrosamine (AMN) in drinking water. In the present study, the incidence of carcinoma in intact and castrated rats administered AMN with flutamide was sign ificantly lower than that of intact rats administered AMN alone, and the incidence of esophageal carcinoma in intact and castrated rats that were given flutamide after administration of AMN was a little lower than that of intact rats were not given flutamide after administration of AMN. From this investigation, we speculate that flutamide may have antitumor effects on experimental esophageal carcinoma induced by AMN in rats.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 近藤 泰理,生越 喬二,幕内 博康,三富利夫: "抗アンドロゲン剤の食道癌治療応用に関するラット発癌実験を用いた研究" 日本外科学会雑誌. 臨時増刊. 289- (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤 泰理,上條 あけみ,生越 喬二,幕内 博康,三富 和夫,泰 順一: "AMNラット実験食道癌における抗アンドロゲン剤の発癌抑制効果" 日本癌学会総会記事. 48. 78- (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤 泰理,上條 あけみ,生越 喬二,幕内 博康,三富 利夫,泰 順一: "AMNラット実験食道癌における抗アンドロゲン剤の治療効果に関する研究" 日本癌学会総会記事. 49. 108- (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.KONDOH,K.OGOSHI,T.TAJIMA and T.MITOMI: "ANTITUMOR EFFECTS OF FIUTAMIDE ON EXPERIMENTAL ESOPHAGEAL CARCINOMA INDUCED BY NーAMYLーNーMETHYLNITROSAMINE(AMN) IN RATS" Jounal of Cancer Research and clinicol Oncology. 116. 459- (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] "Antitumor effects of flutamide on experimental esophageal carcinoma induced by N-Amyl-N-methylnitrosamine in rats" Journal of Cancer Research and Clinical Oncology. Vol. 116. 459 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤 泰理.上條 あけみ.生越 喬二 幕内 博康.三富 利夫.秦 順一: "AMNラット実験食道癌における抗アンドロゲン剤の治療効果に関する研究" 日本癌学会総会記事. 49. 108 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.KONDOH,K.OGOSHI,T.TAJIMA and T.HITOMI: "ANTITUMOR EFFECTS OF FlUTAMIDE ON EXPERIMENTAL ESOPHAGEAL CARCINOMA INDUCED BY NーAMYLーNーMETHYLNITROSAMINE(AMN) IN RATS" Journal of Canor Research and clinicol Dncology. 116. 459 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 近藤泰理: "抗アンドロゲン剤の食道癌治療応用に関するラット発癌実験を用いた研究" 日本外科学会雑誌. 289 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 近藤泰理: "AMNラット実験食道癌における抗アンドロゲン剤の発癌抑制効果" 日本癌学会総会記事. 第48回. 78 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 近藤泰理: "AMNラット実験食道癌における抗アンドロゲン剤の治療効果に関する研究" 日本癌学会総会記事. 第49回. (1990)

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi