| Project/Area Number |
01570775
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
HANEDA Kiyoshi Tohoku University, School of Medicine, Department of Thoracic and Cardiovascular Surgery, Associate Professor, 医学部, 助教授 (90111286)
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| Co-Investigator(Kenkyū-buntansha) |
TOGO Takao Tohoku University School of Medicine, Department of Thoracic and Cardiovascular, 医学部附属病院, 助手 (00188707)
TABAYASHI Koichi Tohoku University School of Medicine, Department of Thoracic and Cardiovascular, 医学部附属病院, 講師 (90142942)
伊東 孝 東北大学, 医学部附属病院, 講師 (30111272)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Fontan's operation / Cardiomyoplasty / Right heart assist / Pedicle skeletal muscle / Fatigue resistant skeletal muscle / 有茎骨格筋移植 / 抗疲労性骨格筋 / 有茎骨格移植 |
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| Research Abstract |
This study was conducted to investigate the effect of right heart assist by pedicle skeletal muscle on the hemodynamics after Fontan's operation in order to extend its operative indication. Experimental Fontan's operation model in which experimental animals could survive for long term periods was established. In comparison of the hemodynamic data between normal and Fontan's circulations, systemic blood pressure and cardiac output in Fontan's circulation decreased to 50-70% and 30-50% of the levels in normal circulation, respectively. On the other hand, pulmonary vascular resistance increased to 2.6 times normal level after Fontan's operation. It was recognized that skeletal muscle sutured to either the right atrium or right ventricle acted as a right heart assist device when it was stimulated by burst impulse, but it was easy to fatigue during continuous stimulation. After Fontan's operation, the latissimus dorsi muscle wrapping around the left and right ventricles was stimulated by burst impulse. This muscle stimulation caused an increase of blood pressure and cardiac output to 130 and 170% of the values before stimulation, respectively. Pulmonary vascular resistance was reduced to 40% of the Fontan's circulation level.
From these results it was concluded that right heart assist by electrical stimulation of pedicle skeletal muscle implanted around the heart improved hemodynamics after Fontan's operation. Further study is necessary to define adequate implantation portion of the skeletal muscle and better stimulation mode, and to make fatigue resistant muscle in order to have more effective right heart assist.
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