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Blood Flow Dynamics of Left Coronary Artery in Hypertrophied Human Heart

Research Project

Project/Area Number 01570796
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKawasaki Medical School

Principal Investigator

FUJIWARA Takashi  Dep. Cardiac Surgery, Kawasaki Medical School, 医学部・心臓外科, 教授 (90090224)

Co-Investigator(Kenkyū-buntansha) KAJIYA Fumihiko  Dep. Medical Engineering, Kawasaki Medical School, 医用工学, 教授 (70029114)
FUKUDA Hisaya  Dep. Thoracic Surgery, Kawasaki Medical School, 胸部外科, 助手 (50199238)
NOGAMI Atsushi  Dep. Cardiac Surgery, Kawasaki Medical School, 心臓外科, 講師 (60140521)
KATSUMURA Tatsuki  Dep. Thoracic Surgery, Kawasaki Medical School, 胸部外科, 教授 (70090222)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordscoronary artery / flow velocity wave form / left ventricular hypertrophy / pulsed Doppler velocimeter / atrial pacing / 左冠動脈血流波形 / 大動脈弁狭窄症 / 人工弁置換術
Research Abstract

To clarify the characteristics of the left coronary blood flow velocity wave forms in left ventricular hypertrophy, we analyzed phasic flow velocity wave forms of left anterior descending coronary artery (LAD) in the patients with aortic regurgitation and stenosis before and after aortic valve replacement using an 80-channel 20 MHz pulsed Doppler velocimeter, and the influence of increase in heart rate on the velocity wave forms was studied by atrial pacing during cardiac operations.
In aortic regurgitation, the LAD flow was characterized by an increase in the systolic flow component, a small and rapidly decreased diastolic flow. An increase in heart rate by pacing brought about a decrease in systolic flow and an increase in diastolic flow component. After aortic valve replacement, systolic flow decreased by 36.3 + 21.7%, whereas diastolic flow markedly increased by 81.4 + 51.8%. These findings suggest that the increase in heart rate in aortic regurgitation and aortic valve replacement … More induce beneficial effects on the myocardial inflow.
The LAD flow velocity wave form in aortic stenosis was characterized by a reverse flow in systole and a slowly increasing diastolic inflow. The time from onset of diastole to the diastolic peak velocity (T-DPV) lengthened in all patients and did not change after an increase in heart rate by pacing. The apparent changes in diastolic flow pattern were observed at the pacing rate of 120, that was, the peak region of diastolic flow velocity overlapped with QRS of subsequent systole, therefore, increasing diastolic inflow rapidly decreased. These findings suggest that the increase in heart rate brings about markedly decrease in coronary blood flow in aortic stenosis. After aortic valve replacement, the increasing rate of the diastolic inflow was augmented and T-DPV was shortened from 176.8 + 28.8 to 90.5 + 18.8 cm/s. In addition, the diastolic peak velocity increased from 90.5 + 28.0 to 122.5 + 17.2 cm/s. These changes suggest the beneficial effects of removal of aortic stenosis on human coronary artery inflow. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Takashi Fujiwara: "Coronary flow velocity waveforms in aortic stenosis and the effects of valve replacement." Ann Thorac Surg. 48. 518-522 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Phasic characteristics of coronary artery blood flow in aortic valvular disease and the effects of surgery." Rinsho Kyobu Geka. 10. 141-145 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fumihiko Kajiya: "Mutigated 20 MHz dual mode(ZerocrossーFourier Transform)Ultrasound pulsed Doppler velocimeter and its application to the measurement of human coronary artery blood flow." Gordon and Breach Science Publishers Inc.(United Kingdom),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Coronary Circulation.Basic mechanism and clinical relevance.Blood velocity waveforms in coronary bypass grafts." SpringerーVerlag Tokyo, 10 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Coronary Circulation.Basic mechanism and clinical relevance.Characteristics of coronary artery blood velocity waveforms in aortic stenosis and regurgitation." SpringerーVerlag Tokyo, 7 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fumihiko Kajiya: "Coronary Circulation.Basic mechanism and clinical relevance.Flow dynamics in coronary stenosis." SpringerーVerlag Tokyo, 9 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Coronary flow velocity wave forms in aortic stenosis and the effects of valve replacement" Ann Thorac Surg. 48. 518-522 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Phasic characteristics of coronary artery blood flow in aortic valvular disease and the effects of surgery." Rinsho Kyobu Geka. 10. 141-145 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fumihiko Kajiya: "Mitigated 20 MHz dual mode (Zerocross+Fourier Transform) Ultrasound pulsed Doppler velocimeter and its application to the measurement of human coronary artery blood flow." Gordon and Breach Science Publishers Inc. (United Kingdom).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Coronary Circulation. Basic mechanism and clinical relevance. Blood velocity wave forms in coronary bypass grafts." Springer-Verlag Tokyo. 325-334 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takashi Fujiwara: "Coronary Circulation. Basic mechanism and clinical relevance. Characteristics of coronary artery blood velocity wave forms in aortic stenosis and regurgitation." Springer-Verlag Tokyo. 306-312 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fumihiko Kajiya: "Coronary Circulation. Basic mechanism and clinical relevance. Flow dynamics in coronary stenosis." Springer-Verlag Tokyo. 296-304 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤原 巍: "大動脈弁膜症における冠動脈血流の拍動特性と手術の効果" 臨床胸部外科. 10. 141-145 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takashi Fujiwara: "Influence of heart rate on coronary flow velocity waveforms in aortic stenosis." 3rd Annual Meeting International Society of Cardio Thoracic Surgeons,July 26,1990.Morioka Japan.

    • Related Report
      1990 Annual Research Report
  • [Publications] Humihiko Kajiya: "Coronary Circulation Basic mechanism and clinical relevance.Flow dynamics in coronary stenosis" SpringerーVerlag Tokyo, 10 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takashi Fujiwara: "Coronary Circulation Basic mechanism and clinical relevance.9:Characteristics of coronary artery blood velocity waveforms in aortic stenosis and regurgitation" SpringerーVerlag Tokyo, 8 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takashi Fujiwara: "Coronary Circulation Basic mechanism and clinical relevance.9:Blood velocity waveforms in coronaty bypass grafts" SpringerーVerlag Tokyo, 9 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Fujiwara,A.Nogami,H.Masski,H.Yamane,S.Matsuoka,H.Yoshida,H.Fukuda,T.Katsumura,F.Kajiya: "Coronary Flow Velocity Waveforms in Aortic Stenosis and the Effects of Valve Replacement" Ann Thorac Surg. 48. 518-522 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤原巍、勝村達喜、野上厚志、山根高廣、吉田浩、福田久也: "大動脈弁膜症における冠動脈血流の拍動特性と手術の効果" 臨床胸部外科.

    • Related Report
      1989 Annual Research Report
  • [Publications] F.Kajiya,Y.Ogasawara,K.tsujioka,T.fujiwara: "Multigated 20 MHz Dual Mode(Zerocross+Fourier Transform)Ultrasound Pulsed Doppler Velocimeter and Its Application to the Measurement of Human Coronary Artery Blood Flow" Gordon and Breach Science Publishers Ine.(United Kingdom), 11 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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