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Development of Hybrid Artificial Graft With Hierarchical Tissue Structure

Research Project

Project/Area Number 01570797
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MATSUDA Takehisa  Head, Dept. of Bioengineering National Cardiovascular Center, 生体工学部, 部長 (60142189)

Co-Investigator(Kenkyū-buntansha) TAKAICHI Shigeko  Research Associate Dept. of Cardiovascular Diseases National Cardiovascular Cent, 病因部, 研究員 (00093930)
小関 英一  国立循環器病センター研究所, 人工臓器部, 研究員 (30192529)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsHybrid Artificial Graft / Endothelial Cells / Smooth Muscle Cells / 人工血管
Research Abstract

Development of Hybrid Artificial Graft ; Fast Nass Culturing & Seeding on Compliant Small-Diameter Artificial Grft. The fast mass culturing of bovine endothelial cells (ECs) were successfully achieved by using collagen microsphere in a spiner flask under mild agitation. The seeded cells adhered and grew well on microspheres. The harvesting by tripsinization resulted in a quite high cell proliferation rate perunit volume. The collected cells were seeded on a compliant small-diameter polyurethane graft overlayered with an artificial basement membrame, which is compose a of type I collagen and dermatame sulfate complex gel. The resultant lumen surface resembles well the morphoqlogy of natural vessel.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Niu,Matsuda & Oka: "Endothelializaion on Various Segmented Palyurethanes(SPUS): Cellular Behaviors and Its Substrate Dependency" Frans.Am.Soc.Artifi.Intern.Organs.36. 164-167 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Niu,Matsuda & Oka: "In Vitro Model System of Endothelialization at Anastomotic Site: Endothelial Cell Motility on Artificial Substrates" Trans.Am.Soc.Artif.Intern.Organs.36. 757-760 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsuda & Kurumatani: "SurfaceーInduced in vitro Angiogenesis:Surface Property is Determinant of Angiogenesis" Trans.Am.Soc.Artif.Intern.Organs.36. 192-195 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 丹生 智史,松田 武久,岡 隆宏: "人工材料表面における細胞移動実験法の開発と内皮化の定量的取扱い" 生体材料. 8. 238-241 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Niu, Matsuda & Oka: "Endothelialization on Various Segmented Polyurethones (SPUs) : Cellular Behaviors and Its Substrate Dependency" Trano. Am. Soc. Artif. Intern. Orgamo. 36. 164-167 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Niu, Matsuda & Oka: "In Vitro Model System of Endothelialization at Anastomotic Site : Endothelial Cell Motility on Artificial Substrates" Trans Am. Soc. Artp. Intern. Organ. 36. 757-760 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Matsuda & Kurumatani: "Surface- Induced in Vitro Angiogenesis : Surface Property is Determinant of Angiogenesis" Trans Am. Soc. Artip. Intern. Organ. 36. 192-195 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Niu,Matsuda & Oka: "Endothelialization on Various Segmented Polyurethanes (SPUs):Cellular Behaviors and Its Substrate Dependency" Trans.Am.Soc.Artif.Intern.Organs.36. 164-167 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Niu,Matsuda & Oka: "in Vitro Model System of Endothelialization at Anastomotic Site:Endothelial Cell Motility on Artificial Substrates" Trans.Am.Soc.Artif.Intern.Organs.36. 757-760 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Matsuda & Kurumatani: "SurfaceーInduced in Vitro Argiogenesis:Surface Property is Determinant of Argiogenesis" Trans.Am.Soc.Artif.Intern.Organs.36. 192-195 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 丹生 智史、松田 武久、岡 隆宏: "人工材料表面における細胞移動実験法の開発と内皮化の定量的取扱い" 生体材料. 8. 238-241 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松田武久、北村たかね、高野久輝: "ハイブリッド型人工血管の開発:血管壁細胞の大量迅速培養法の開発と小口径コンプライアンド人工血管への播種" 人工臓器. 18. 304-308 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松田武久、北村たかね、高野久輝: "ハイブリッド型人工血管の開発:人工基底膜の設計" 人工臓器. 18. 298-303 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松田武久、北村たかね、阿久津哲造: "細胞と人工材料との相互作用:血管壁細胞の接着及び伸展過程に関する研究" 人工臓器. 18. 54-58 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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