The "direct" effect of experimental subarachnoid hemorrhage on local cerebral metabolism and blood flow.

Research Project

Project/Area Number	01570801
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Chiba University
Principal Investigator	YAMAURA Akira Chiba University, School of Medicine, Associate Professor, 医学部, 助教授 (40009717)
Co-Investigator(Kenkyū-buntansha)	OSATO Katsunobu Chiba University, School of Medicine, Instructor, 医学部, 助手 (90125906) OKA Nobuo Chiba University, School of Medicine, Instructor, 医学部, 助手 (40114251) NAKAMURA Takao Chiba University, School of Medicine, Instructor, 医学部, 助手 (70155836) 伊藤千秋千葉県こども病院, 医長和賀井望千葉大学, 医学部, 医員牧野博安千葉大学, 医学部, 教授 (10009095)
Project Period (FY)	1989 – 1990
Project Status	Completed (Fiscal Year 1990)
Budget Amount *help	¥2,000,000 (Direct Cost: ¥2,000,000) Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000) Fiscal Year 1989: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords	subarachnoid hemorrhage / autoradiography / local cerebral glucose utilization / local cerebral blood flow / cerebral edema / cerebral dysfunction / 脳機能障害 / ラット / autoradiography / 局所脳糖代謝率 / 脳血流 / 脳浮腫
Research Abstract	To investigate the "direct" effects of subarachnoid hemorrhage (SAH) on cerebral blood flow and metabolism, we developed a new cortical SAH model in rat and measured local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) using it. LCGU and LCBF were measured at 2 hours and 48 hours after production to SAH. 1. Change of LCGU : Cortical LCGU of the affected side 2 hours after SAH was significantly reduced and reduction of LCGU remained at 48 hours after SAH but was less significant. LCGU of subcortical structures remained unchanged. 2. Change of LCBF : Cortical LCBF of the affected side 2 hours after SAH was also significantly reduced. These results show that fresh blood in the subarachnoid space has "direct" effect on cerebral metabolism and circulation.