• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The "direct" effect of experimental subarachnoid hemorrhage on local cerebral metabolism and blood flow.

Research Project

Project/Area Number 01570801
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionChiba University

Principal Investigator

YAMAURA Akira  Chiba University, School of Medicine, Associate Professor, 医学部, 助教授 (40009717)

Co-Investigator(Kenkyū-buntansha) OSATO Katsunobu  Chiba University, School of Medicine, Instructor, 医学部, 助手 (90125906)
OKA Nobuo  Chiba University, School of Medicine, Instructor, 医学部, 助手 (40114251)
NAKAMURA Takao  Chiba University, School of Medicine, Instructor, 医学部, 助手 (70155836)
伊藤 千秋  千葉県こども病院, 医長
和賀井 望  千葉大学, 医学部, 医員
牧野 博安  千葉大学, 医学部, 教授 (10009095)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordssubarachnoid hemorrhage / autoradiography / local cerebral glucose utilization / local cerebral blood flow / cerebral edema / cerebral dysfunction / 脳機能障害 / ラット / autoradiography / 局所脳糖代謝率 / 脳血流 / 脳浮腫
Research Abstract

To investigate the "direct" effects of subarachnoid hemorrhage (SAH) on cerebral blood flow and metabolism, we developed a new cortical SAH model in rat and measured local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) using it.
LCGU and LCBF were measured at 2 hours and 48 hours after production to SAH.
1. Change of LCGU : Cortical LCGU of the affected side 2 hours after SAH was significantly reduced and reduction of LCGU remained at 48 hours after SAH but was less significant. LCGU of subcortical structures remained unchanged.
2. Change of LCBF : Cortical LCBF of the affected side 2 hours after SAH was also significantly reduced.
These results show that fresh blood in the subarachnoid space has "direct" effect on cerebral metabolism and circulation.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 伊藤 千秋 他: "脳表くも膜下出血の脳グルコ-ス代謝におよぼす影響" 脳と神経. 43. 30-36 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ito C. et. al: "The Effect of Cortical Subarachnoid Hemorrhage on Cerebral Glucose Metabolism." Brain and Nerve. 43 ・ 1. 30-36

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 伊藤 千秋,他: "脳長くも膜下出血の脳グルコ-ス代謝におよぼす影響" 脳と神経. 43. 30-36 (1991)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi