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The study of experimental cerebral aneurysms using in vitro simulator

Research Project

Project/Area Number 01570806
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNagoya University

Principal Investigator

NEGORO Makoto  Nagoya University School of Medicine Lecturer, 医学部, 助手 (90115618)

Co-Investigator(Kenkyū-buntansha) MIYACHI Shigeru  Nagoya University School of Medicine Assistant, 医学部, 医員
HANDA Takashi  Nagoya University School of Medicine Assistant, 医学部, 医員
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
KeywordsSimulator / Cerebral aneurysn / Balloon catheter / Metallic coil / ズル-ンカテ-テル / 圧計測 / シュミレ-ション / ダブルバル-ン / ビデオモニタ- / 乱流
Research Abstract

We have created an experimental model for cerebral aneurysms using an infusion pump and glass models. It can be used as a simulation model for the endovascular treatment of cerebral aneurysms. As the technical point, three techniques were established with two balloons : " Guiding", whereby one reverses flow direction with a pilot balloon, thus directing the second balloon into an aneurysm. And "Squeezing", "Coupling" techniques were also established.
We also measured the intraaneurysmal pressure during the procedures and found 50 mmhg elevation above the systemic level. It suggested that if there is remaining space between balloons or aneurysmal wall, the pressure can be high enough to rupture the aneurysm.
Furthermore, we found the fact that a latex balloon is able to occlude the aneurysmal cavity better than a silicone balloon. It confirmed the same fact which was obtained from our in vivo experiment.
We also tested a metallic coil for the intraaneurysmal cavity and found a delay of total occlusion.
This simulation model has the benefit of direct visualization of the endovascular orocedures and could be a good training device.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] M.Negoro et al: "Endorascohar trentment for experimental aneurysm" Neuroradiology. 33. 424-425 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 根来 真他: "動脈瘤に対する血管内治療法" 第5回日本脳神経血管内手術研究会講演集. 79-83 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 宮地 茂他: "in vitroシュミレ-タ-の血管内手術への応用" 第5回日本脳神経血管内手術研究会講演集. 27-30 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Negoro et al: "Extracranial vertebral artery anenrysm with neurofibromatosis" Neuroradiology. 31. 533-536 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Negoro: "Endovascular treatment for experimental aneurysm" Neuroradiology. 33. 424-425 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Negoro: "Endovascular treatment for cerebral aneurysm" Proceeding of JIVS. 5. 79-83 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Miyachi: "The application of an in-vitro simulator model for endovascular surgery" Proceeding of JIVS. 5. 27-30 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Negoro: "Extracranial vertebral artery aneurysm with neurofibromatosis" Neuroradiology. 31. 533-536 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Negoru et al: "Endovascular theatment for experimental aneurysm" Neuroradiolgy. 33. 424-425 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 根来 真 他: "動脈瘤に対する血管内治療法" 神経放射学の進歩. 2. 54-55 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 根来真: "動脈瘤に対する血管内治療法" 第5回日本脳神経血管内手術法研究会講演集. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 宮地茂: "in vitroシュミレ-タ-の血管内治療法への応用" 第5回日本脳神経血管内手術法研究会講演集. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Negoro: "Extracranial vertebral artery aneurysm with neurofibromatosis" Neuroradiology. 31. 533-536 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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