• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Microcirculatory Disturbances in Cerebral Ischemia ; Analysis of Pathophysiology and Therapeutic Approach.

Research Project

Project/Area Number 01570810
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

YOSHIMINE Toshiki  Osaka Univ., Med. School, Assistant, 医学部, 助手 (00201046)

Co-Investigator(Kenkyū-buntansha) MORIMOTO Kazuyoshi  Osaka Univ., Med. School, Lecturer, 医学部, 講師 (50116117)
HAYAKAWA Toru  Osaka Univ., Med. School, Professor, 医学部, 教授 (20135700)
加藤 天美  大阪大学, 医学部附属病院, 医員
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
KeywordsCerebral ischemia / Microcirculation / Red blood cell / Platelet / White blood cell / Superoxide / 血漿 / 高血圧 / SHRSP
Research Abstract

1. Progression of Microcirculatory Disturbance in Focal Cerebral Ischemia.
Changes in the regional cerebral blood flow (rCBF) and the length of plasma-perfused microvessels were studied after occlusion of the middle cerebral artery (MCA) in rats or the posterior communicating artery (P-com) in gerbils. The data demonstrated that the rCBF decreased markedly within several minutes after arterial occlusion, while the disturbances in microvascular plasma perfusion appeared 30 min or 1 hour later which further deteriorated for the following several hours.
2. Therapeutic approach to microvascular deterioration.
To investigate the effects of tissue-type plasminogen activator (tPA) and Cu, Zn-superoxide dismutase (SOD) on the microvascular deterioration during cerebral ischemia, recombinant human tPA and SOD were continuously applied in rat MCA occlusion model. The results indicated that intravenous application of those enzymes significantly improved the microvascular plasma circulation.
3. Microcirculation in Hypertensive Rats.
The microvascular length per unit volume was measured in the strokeprone spontaneously hypertensive Rats (SHRSP) and the age-matched Wistar Kyoto rats. The data demonstarted that the microvascular length was decreased in several areas of the brain in SHRSP. Daily administrattion of elastase prepartion improved the microvascular plasma perfusion in SHRSP.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (52 results)

All Other

All Publications (52 results)

  • [Publications] 竹本 理: "梗塞巣周辺脳における細胞増殖性変化の検討。抗astroprotein(GFAP)抗体および抗Brdu抗体を用いた免疫組織学的研究。" 脳神経. 41. 361-365 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 嶋田 延光: "脳虚血急性期の脳内 SーadenosylーLーmethionine の変動とエネルギ-代謝" 脳卒中. 11. 81-88 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 正名 好之: "脳虚血における脳内 purine 作動性物質の動態ー脳微小透析法と脳組織抽出法との比較検討。" 脳神経. 41. 687-693 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Amami Kato: "Quantitative morphometric analysis of parenchymal microperfusion in focal cerebral ischemia with doubleーlabeled serum method." Journal Cerebral Blood Flow and Metabolism. 9. S179 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kazumi Yamamoto: "Effect of extract of infantile bovine blood(Solcoseryl)on delayed neuronal death in the gerbil hippocampus." Cytoprotection and Cytobiology. 6. 289-293 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 新居 康夫: "興奮性アミノ酸による脳組織間質液中アデノシンの動態ー脳微小透析法を用いたラット海馬での検討。" Cytoーprotection and Biology. 7. 309-316 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "作用持続型 NGF miniーpellet による海馬遅発性神経細胞壊死の防止" 神経組織の成長・再生・移植. 1. 63-64 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Eiji Kumura: "Effect of recombinant human SOD on the microcirculatory change in rat focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism. 11. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takeshi Mushiroi: "Stab wound prevents delayed neuronal death in the gerbil hippocampus." Journal of Cerebral Blood Flow and Metabolism. 9. S188 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshiki Yoshimine: "rCBF versus microvascular plasma circulation in focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism. 9. S170 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳卒中実験ハンドブック(第4章 微小循環実験法)" アイピ-シ-, 857(66) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "虚血と臓器障害ー虚血によって何が起こるか?(脳虚血による微小循環障害と細胞傷害の発生)" ヘルス出版, (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳卒中実験ハンドブック(砂ネズミ中大脳動脈閉塞モデル並びに後交通動脈閉塞モデルー作成の実際と問題点)" アイピ-シ-, 857(8) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳虚血モデル)" アイピ-シ-, 857(12) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(慢性脳虚血モデル)" アイピ-シ-, 857(2) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(動物実験モデルの選択)" アイピ-シ-, 857(6) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(ネコ中大脳動脈閉塞モデルー経眼窩接近法と本モデルの特徴・問題点)" アイピ-シ-, 857(8) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(Pulsinelli and Brierly のラット4血管閉塞モデル(前脳虚血モデル)について)" アイピ-シ-, 857(2) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 森本 一良: "脳卒中実験ハンドブック(脳代謝測定法ー生化学的方法)" アイピ-シ-, 857(12) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 加藤 天美: "脳卒中実験ハンドブック(脳代謝測定法ーオ-トラジオグラフィ-法)" アイピ-シ-, 857(31) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳循環測定法の実際ー熱電対法)" アイピ-シ-, 857(6) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳循環測定法の実際ーCranial window 法)" アイピ-シ-, 857(4) (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemoto O, Yoshimine T, Hayakawa T, Fujita T, Nakajima S, Taneda M< Mogami H: "Astrocytic proliferation in the brain adjacent to infarcted lesion. Immuno-histochemical study with astroprotein (GFAP) and bromodeoxyuridine (BrdU)." Brain Nerve. 41. 361-365 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shimada N, Morimoto K, Hayakawa T, Yoshimine T, Mogami H: "Study of S-adenosyl-methionine in ischemic gerbil brain and effect on its systemic administration of cerebral energy metabolism." Jap. J. Stroke. 11. 81-88 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masana Y, Morimoto K, Hayakawa T, Shimuzu H, Shimada N, Nii Y, Yoshimine T, Mogami H, Hashimoto T: "Extracellular tissue nucleotides and purine catabolites during progression and recovery of ischemia." Brain Nerve. 41. 687-693 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kato A, Yoshimine T, Hayakawa T, Nakajima S, Mushiroi T, Mogami H: "Quantitative morphometric analysis of parenchymal microcirculation in focal cerebral ischemia with double-labeled serum method." J Cereb Blood Flow Metabolism. 9. 179 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamamoto K, Yoshimine T, Morimoto K, Shimada N, Hayakawa T, Mogami H: "Effect of extract of infantile bovine blood (Solcoseryl) on delayed neuronal death in the gerbil hippocampus." Cytoprotection and Cytobiology. 6. 289-293 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nii Y, Morimoto K, Hayakawa T, Hata J, Mushiroi T, Shimizu H, Masana Y, Yoshimine T, Mogami H: "Effect of excitatory amino acids on the interstitial adenosine concentration." Cyto-protection and biology. 7. 309-316 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshimine T, Hayakawa T, Kumura E, Mogami H, Yamamoto S, moto S, Fujiwara M, Irie T, Fujioka K: "Prevention of hippocampal delayed neuronal death by long-acting NGF mini-pellet." Neural Growth. Regeneration and Transplantation. 1. 63-64 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumura E, Yoshimine T, Kato A, Nakajima S, Hayakawa T: "Effect of recombinant human SOD on the microcirculatory change in rat focal cerebral ischemia." J Cereb Blood Flow Metabolism. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mushiroi T, Yoshimine T, Hayakawa T, Mogami H: "Stab wound prevents delayed neuronal death in the gerbil hippocampus." J Cereb Blod Flow Metabolism. 9. 188 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshimine T, Nakajima S, Hayakawa T, Kato A, Mushiroi T: "rCBF versus microvascular plasma circulation in focal cerebral ischemia." J Cereb Blood Flow Metabolism. 9. 170 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Eiji Kumura: "Effect of recombinant human SOD on the microcirculatory change in rat focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism. 11. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳卒中実験ハンドブック(第4章 微小循環実験法)" アイピ-シ-, 857(66) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 吉峰 俊樹: "虚血と臓器障害ー虚血によって何がおこるか?(脳虚血による微小循環障害と細胞傷害の発生)" ヘルス出版, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(慢性脳虚血モデル)" アイピ-シ-, 857(2) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(動物実験モデルの選択)" アイピ-シ-, 857(6) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳卒中実験ハンドブック(砂ネズミ中大脳動脈閉塞モデル並びに後交通動脈閉塞モデルー作成の実際と問題点)" アイピ-シ-, 857(8) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳虚血モデル)" アイピ-シ-, 857(12) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 一良: "脳卒中実験ハンドブック(脳代謝測定法ー生化学的方法)" アイピ-シ-, 857(12) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 加藤 天美: "脳卒中実験ハンドブック(脳代謝測定法ーオ-トラジオグラフィ-法)" アイピ-シ-, 857(31) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(ネコ中大脳動脈閉塞モデルー経眼窩接近法と本モデルの特徴・問題点)" アイピ-シ-, 857(8) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(Pulsinelli and Brierlyのラット4血管閉塞モデル(前脳虚血モデル)について)" アイピ-シ-, 857(2) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳循環測定法の実際ー熱電対法)" アイピ-シ-, 857(6) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 徹: "脳卒中実験ハンドブック(脳循環測定法の実際ーCranial window法)" アイピ-シ-, 857(4) (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yoshimine,T: "rCBF versus microvascular plasma circulation in focal cerebral ischemia." Journal of Cerebral Blood Flow and Metabolism. 9. S170 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kato,A: "Quantative morphometric analysis of parenchymal microperfusion in focal cerebral ischemia with doublelabeled serum method." Journal of Cerebral Blood Flow and Metabolism. 9. S179 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 嶋田延光: "脳虚血急性期の脳内SーadenosylーLーmethionineの変動とエネルギ-代謝" 脳卒中. 11. 81-88 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 正名好之: "脳虚血における脳内purine作動性物資の動態ー脳微小透析法と脳組織抽出法との比較ー" 脳と神経. 41. 687-693 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 新居康夫: "興奮性アミノ酸による脳組織間質液中アデノシンの動態ー脳微小透析法を用いたラット海馬での検討ー" Cytoprotection and Biology. 7. 309-316 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉峰俊樹: "脳卒中実験マニュアル.第4章微小循環実験法" アイピ-シ-, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 吉峰俊樹: "脳卒中実験マニュアル.メモ:砂ネズミ後交通動脈閉塞モデル,中大脳動脈閉塞モデル" アイピ-シ-, (1990)

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi