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Embryopathogenesis of experimental CNS malformations and functional recovery by fetus to fetus neurostransplantation

Research Project

Project/Area Number 01570812
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKobe University

Principal Investigator

OI Shizuo  Kobe University, School of Medicine Hospital Assistant Professor, 医学部附属病院, 講師 (30194062)

Co-Investigator(Kenkyū-buntansha) KOKUNAI Takashi  Kobe University, School of Medicine Hospital Research Associate, 医学部附属病院, 助手 (30178248)
YAMADA Hiroshi  Kobe University, School of Medicine Research Associate, 医学部, 助手 (10220401)
MATSUMOTO Satoshi  Kobe University, School of Medicine Professor, 医学部, 教授 (10030850)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsCNS malformation / Dysraphism / Experimental model / Whole embryo culture / Neuro-transplantation / Fetal surgery / Neuronal regeneation / 中枢神経奇形 / 動的実験モデル
Research Abstract

Abstract
The paraplegic status in patient with spina bifida(myeloschisis), which is the most common cause for congential paraparetic condition, remains for the entire life of the patient The operative indications and therapeutic modalities have been controversial and it is now becoming more apparent that there are two contradictory therapeutic goals to be selected, termination of the pregnancy under the prenatal diagnosis or radical surgical intervention to reconstruct the neural structures. In early 1980s, clinical application of nerve anastomosis in patients with spina bifida was reported by two authors(Epstein F. et al and Oi, S. et al), namely "Intercostal Nerve to lumbar Nerve Root Anastomosis". The results were not satisfactory enough to obtain the functional recovery.
Based on these historical backgrounds, the authors have investigated the neuronal maturation process in dysraphic states both in the clinical examples and the experimental models. The results disclosed a fact that th … More e neuronal developments were not monotonously suppressed but partly overmatured. The overmatured neuronal components included somatostatin - positive element suggesting the direction of the neuronal overmaturation or developmental error- of certain neuropeptide. These disorderly developed neurons were diffusely identified in cephalic -dysraphysm, while the neural placode was the focus to grow such overgrown neurons in spinal dysraphism. By using a whole-embryo culture technique, a new experimental rat spina bifida model induced by vitamin A was also intended to be made, and its embryopathogenesis was investigated from a viewpoint of morphology. Furthermore, a fetus to fetus spinal cord transplantation was performed to repair the congenital gap of the spinal cord neural function in this model. From the knowledge obtained in these studies, it was emphasized that the neural reconstructive procedure should be undertaken on the process of neuronal maturation, i. e. during the fetal period, in order to develop the proper neural networks and neural connections. Less

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Shizuo Oiら: "Neuronal overmaturation in dysraphism:ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in exencephaly" J.Neurosurgery.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oiら: "Neurovascular developmental interaction:Aspecific form of vascular maldevelopment in malformed brainーAn experimental studyー" Pediatric Neurosurgery.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oiら: "Neuronal maturation process in spinal dysraphism and possibility of functional recovery from paraplegia" Proceedings of International workshop on Newrobionics.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oi, Hiroshi Yamada, Seishiro Urui, Takeshi, Kondo, et al: "Neuronal overmaturation in dysraphysm : Ontogenic expression of neuropeptodes in the fetal brain and developmental anomalies in exencephaly" J. Neurosurgery,.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oi, Seishiro Urui, Takeshi Kondo et al: "Neurovascular developmental interaction : A specific form of vascular maldevelopment in malformed brain -- An experimental study--" Pediatric Neurosurgery.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oi, M. D., et al: "Neuronal Maturation process in spinal dysraphism and possible functional recovery from paraplegia." Proceedings of International Workshop on Neurobionics.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shizuo Oi 他: "Neuronal overmaturation in dysraphism:ontogenic expression of neuropeptides in the fetal brain and developmental anomalies in exencephaly" J.Neurosurgery.

    • Related Report
      1991 Annual Research Report
  • [Publications] Shizuo Oi 他: "Neurovascular developmental interaction:Aspecific form of vascular maldevelopment in malformed brain ーAn experimental studyー" Pediatric Neurosurgery.

    • Related Report
      1991 Annual Research Report
  • [Publications] Shizuo Oi 他: "Neuronal maturation process in spinal dysraphism and possibility of functional recovery from paraplegia" Proceedings of International workshop on Newrobionics.

    • Related Report
      1991 Annual Research Report
  • [Publications] 潤井 誠司郎: "ラット全胚培養法によるビタミンA誘発二分脊椎実験モデルの開発と発生病態解析" 神戸大学紀要. 51. 285-296 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 潤井誠司郎: "Vitamin A誘発中枢神経系奇形モデルにおける癒合不全発生過程の全胚培養下での形態学的検索" 神戸大学紀要.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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