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Cloning of Glicma Specific Tumor Supressor Gene

Research Project

Project/Area Number 01570819
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionDokkyo University School of Medicine

Principal Investigator

NAGAI Masakatsu (1990)  Dokkyo University School of Medicine, Neurosurgery, Professor, 医学部, 教授 (50049136)

新井 紀元 (1989)  獨協医科大学, 医学部, 助教授 (40103296)

Co-Investigator(Kenkyū-buntansha) WATANABE Kunihiko  Dokkyo University School of Medicine, Neurosurgery, Assistant, 医学部, 助手 (00230954)
永井 政勝  獨協医科大学, 医学部, 教授 (50049136)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsglioma / tumor supressor gene / RFLP / revertant / 発癌制遺伝子 / 悪性グリオ-マ / 遺伝子欠損
Research Abstract

Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma ( seven glioblastomas and two malignant astrocytomas ) was investigated. Loss of constitutional heterozygosity was found in four of the seven ( 57% ) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytoma cases. One glioblastoma case showed loss of constitutional heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Kunihiko Watanabe: "Loss of constitutional heterozygosity in chromsome10in human glioblastoma" Acta Neuropathologica. 80. 251-254 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kunihiko Watanabe, Masakatsu Nagai, Susumu Wakai, Toshimoto Arai and Kazuko Kawashima: "Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma" Acta Neuropathologica. 80. 251-254 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kunihiko W tanabe: "Loss of constitutional heterozygosity in chromsome 10 in human glioblastoma" Acta Neuropathologica. 80. 251-254 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kunihiko Watanabe: "Loss of Constitutional Heterozygosity in chromosome 10 in Human Glioblastoma" Acta Neuropathologica.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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