| Project/Area Number |
01570821
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokai University |
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Principal Investigator |
SATO Osamu Tokai University, School of Medicine, Department of Neurosurgery, Professor, 医学部, 教授 (00023763)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEI Futoshi Tokai University, School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (00216839)
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | hydrocephalus / periventricular tissue / cerebrospinal fluid / tissue water content / electronmicroscopy / ventriculo-pleural shunt / craniectomy |
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| Research Abstract |
Results :
Before shunt was put in water content in the subependymal tissue immediate underneath the ependymal cells was 72.2+__-l. 0 % and much increased than the water content of deep white matter tissue of 67.2 +__- 0.7 % The results indicate that water content is definitely increased just underneath the ventricular surface but increased than the water content of deep white matter tissue of 67.2+__-0.7 %. In the animals in which shunt did work, its water content in the subependymal tissue was 70.9+__-1.1% and this was not different from the control animals. In animals which failed to function after shunting water content did not decreased as might be expected and interestingly enough its water content in the deeper tissue was increased. Electron microscopic examination, however, did not show marked enlargement of the extracellular space in the deep white matter and also derangement of the axons and myelin fibers were not prominent at all.
From the series of our experiment it was learned that if shunt procedure failed to reduce the ventricular size water content in the deep white matter, when say that it is only 2 or 3 mm from the ependymal surface though increased definitely suggesting an important role of the subependymal tissue as a subsidiary way of cerebrospinal fluid circulation.
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