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Development of Toughened Porous Hydroxyapatite Sintered Body for Artificial Bone

Research Project

Project/Area Number 01570848
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKitasato University

Principal Investigator

MATSUNO T.  Kitasato University, School of Medicine, Associate Professor, 医学部, 助教授 (80104537)

Co-Investigator(Kenkyū-buntansha) SAKURAI K.  Kitasato University, School of medicine, Assistant Professor, 医学部, 講師 (60050506)
KOISHI M.  Science University of Tokyo, Faculty of Industrial Science and Technology, Profe, 基礎工学部, 教授 (70084423)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsHydroxyapatite / Sintered Body / Porous Sintered Body / Fracture Toughness / Artificial Bone / 破壊靭性値 / CTスキャナ / 均質性評価 / 球晶
Research Abstract

1. The fine rod-like hydroxyapatite(HAP) crystals and spherical HAP particles were prepared with calcium nitrate tetrahydrate and diammonium hydrogenphosphate by the semibatchwise homogeneous reaction. The spherical particle's were obtained by addition of sodium citrate(1x10^<-3> mol/l) to the reaction system.
2. An investigation was undertaken to determine the effect of various conditions on preparation of HAP spherulite in agar-agar gel. It was revealed that the existence of small amounts of additives promote the formation of spherical HAP or amorphous calcium phosphate particles. The more detailed studies will be carried out for obtaining information on the mechanism of the spherical particle formation.
3. Chemical changes of HAP to other calcium phosphate compounds by the calcination and(or) the sintering process were investigated. In the case of Ca/P molar ratio of HAP was close to the theoretical value of 1.67, no change was occurred even when it was heated at 1000-1200゚C for 3 hou … More rs. In other cases (Ca/P molar ratio<1.67), it was recognized that HAP was changed to P-calcium phosphate by heating operation.
4. The interesting information, regarding the change of particle size distribution was obtained from a study of the calcination process of the precipitated HAP. The width of the distribution decreased witb decreasing calcination temperatures.
5. Internal homogeneity of the green compact body and the sintered body of HAP was widely studied by a CT-scanner. The sintered body was somewhat more heterogeneous than the corresponding green compact body.
6. The HAP sintered bodies having relative density of 49.4-85.5% were obtained by the compression molding and the heating operation of the particles with varying microstructures. Fracture toughness of these porous HAP sinipied bodi-es was evaluated by a SEVNB method. The values were 0.13-0.76 MPam^<1/2>. A linear relation between the relative density and fracture toughness was recognized ; the fracture toughness increased with an increase of the relative density. Less

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 松野 昂士: "リン酸一水素カルシウム二水和物の球晶状成長" 材料技術. 8. 243-251 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松野 昂士: "常圧半回分式反応法によるヒドロキシアパタイト超微細結晶の合成" 材料技術. 9. 231-237 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松野 昂士: "不均一系反応によるヒドロキシアパタイトの合成およびそのキャラクタリゼ-ション" 色材協会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松野 昂士: "日本セラミックス協会学術論文誌" CT値によるヒドロキシアパタイト焼結体の均質性評価,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松野 昂士: "日本セラミックス協会学術論文誌" 多孔質ヒドロキシアパタイト焼結体の破壊靭性,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuno: "Spherulitic Crystal Growth of Calcium Monohydrogenorthophosphate Dihydrate" J. Jpn. Research Institute of Material Technology. 8. 243-251 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuno: "Preparation of Hydroxyapatite Ultrafine Crystals by the Semibatchwise Operation at Atmospheric Pressure" J. Jpn. Research Institute of Material Technology. 9. 231-237 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuno: "Synthesis of Hydroxyapatite by Heterogeneous Reaction and Its Characterization" J. Jpn. Soc. Color Material.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuno: "Evaluation of Homogeneity for Sintered Hydroxyapatite by CT-values" J. Ceramic Soc. Jpn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuno: "Fracture Toughness of Porous Hydroxyapatite Sintered Bodies" J. Ceramic Soc. Jpn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松野 昂士: "常圧半回分式反応法によるヒドロキシアパタイト超微細結晶の合成" 材料技術. 9. 231-237 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松野 昂士: "不均一系反応によるヒドロキシアパタイトの合成およびそのキャラクタリゼ-ション" 色材協会誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 松野 昂士: "CT値によるヒドロキシアパタイト焼結体の均質性評価" 日本セラミックス協会学術論文誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 松野 昂士: "多孔質ヒドロキシアパタイト焼結体の破壊靭性" 日本セラミックス協会学術論文誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 松野 昂士: "リン酸一水素カルシウム二水和物の球晶状成長" 材料技術. 8. 243-251 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松野 昂士: "常圧半回分式反応法によるヒドロキシアパタイト超微結晶の合成" 材料技術.

    • Related Report
      1990 Annual Research Report
  • [Publications] 松野昂士: "リン酸カルシウムの生体中における結晶成長" 日本結晶成長学会誌. 16. 91-97 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松野昂士: "リン酸-水素カルシウム二水和物の球晶状成長" 材料技術. 8. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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