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Clinical Efficacy and Immunological Response of Microwave Coagulation on Urinary Bladder and Prostatic Cancer

Research Project

Project/Area Number 01570878
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionAkita University School of Medicine

Principal Investigator

MIYAGATA Shigeru (1990-1991)  Akita University School of Medicine Department of Urology Assistant Professor, 医学部, 助手 (00157596)

原田 忠 (1989)  秋田大学, 医学部, 講師 (00108953)

Co-Investigator(Kenkyū-buntansha) SUGAYA Kimio  Akita University School of Medicine Department of Urology Assistant Professor, 医学部, 助手 (20179120)
HARADA Tadashi  Akita University School of Medicine Department of Urology Instructor, 医学部, 講師 (00108953)
宮形 滋  秋田大学, 医学部, 助手 (00157596)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsUrinary bladder cancer / Prostatic cancer / VX-2 Carcinoma / Microwave / Microwave coagulation / Hyperthermia / Immunological inhibitory factor / Ultrasonic monitoring / VXー2腫瘍 / マイクロ波凝固療法 / 組織学的所見 / VX2 / 癌免疫
Research Abstract

In order to evaluate the effectiveness of microwave coagulation therapy on urinary bladder carcinoma, we conducted a series of experiments using carcinoma VX-2 cells designed for application on animal hosts. Three days after implantation of VX-2 cell into the bladder of the rabbits, microwave coagulation therapy was performed. The Anti-tumor effect, i, e, survival rate, histological study, and immunological response, of the microwave therapy was examined in comparison with the control group (no treatment), partial- cystectomy group, and the sham operation group (no tumor cell implantation). The results were obtained as follows : 1) The survival rate in the microwave group was greater than that in the control group. The microwave group, in contrast to the control group, displayed postoperatively a significant increase in body weight. 2)The values of peripheral RBC, hemoglobin, and WBC counts in the microwave group did not present significant fluctuation. However, RBC and hemoglobin values decreased in the control group. 3) The Stimulation Index value (S. 1.), which represents humoral immunity, decreased postoperatively in all groups. In the microwave group, S. 1. increased gradually from 21 days after the transient decrease. 4) Histological findings revealed severe degeneration, necrotization, and complete eradication of cancer cells of the bladder wall in the microwave group, but perforation of the urinary bladder could not be detected.
The results indicate that microwave coagulation therapy is an effective procedure for urinary bladder tumors. Furthermore, microwave therapy may also accelerate the inactivation of immunological suppressers in the carcinoma host, an additional benefit of the microwave procedure.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 木暮 輝明,原田 忠,宮形 滋,他7名: "マイクロ波凝固療法を中心とした膀胱癌の治療成績" マイクロウェ-ブサ-ジェリ-. 8. 57-60 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 原田 忠,木暮 輝明,他6名: "実験的ウサギ移植膀胱腫瘍に対するマイクロ波凝固法の基礎的検討" マイクロウェ-ブサ-ジェリ-. 8. 7-12 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada,T.,et al: "Microwave Coagulation Therapy on VX-2 Carcinoma Implanted in Urinary Bladders" Urologia Internationalis.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada,T.,et al: "Intraoperative Realtime Ultrasonic Scanning for Microwave Coagulation of the Prostate" Urologie Radiology. 12. 45-49 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 原田 忠,木暮 輝明: "泌尿器科疾患に対するマイクロ波を用いた治療法" 日本泌尿器科学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 熊崎 匠,木暮 輝明,他5名: "膀胱癌のマイクロ波凝固治療法における免疫パラメ-タの変動" 泌尿器外科. 2. 901-904 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kigure, T., et al: "Clinical Efficacy of Microwave Coagulation on Urinary Bladder Carcinoma" Microwave Surgery. 8. 57-60 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada, T., et al: "Experimental Study of Microwave Coagulation Therapy on Implanted Urinary Bladder Carcinoma in Rabbits" Microwave Surgery. 8. 7-12 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada, T., et al: "Microwave Coagulation Therapy on VX-2 Carcinoma Implanted in Urinary Bladders" Urologia Internationalis.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada, T., et al: "Intrapoerative Realtime Ultrasonic Scanning for Microwave Coagulation of the Prostate" Urologie Radiology. 12. 45-49 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Harada, T., et al: "Microwave Therapy on Patients with Urological Disease" J. Jap. Urol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kumazaki, T., et al: "Changes of Immunological Parameters after Microwave Coagulation Therapy on Urinary Bladder Cancer" Urologic Surgery. 2. 901-904 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木暮 輝明,原田 忠,宮形 滋,他7名: "マイクロ波凝固療法を中心とした膀胱癌の治療成績" マイクロウェ-ブサ-ジェリ-. 8. 57-60 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 原田 忠,木暮 輝明,他6名: "実験的ウサギ移植膀晄腫瘍に対するマイクロ波凝固法の基礎的検討" マイクロウェ-ブサ-ジェリ-. 8. 1-12 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Harada,T.,et al: "Microwave Coagulation Therapy on VXー2 Carcinama Implanted in Urinary Bladders" Urologia Internationalis.

    • Related Report
      1991 Annual Research Report
  • [Publications] Harada,T.,et al: "Intraoperative Realtime Ultrasonic Scanning for Microwave Coagulation of the Prostate" Urologie Radiology. 12. 45-49 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 原田 忠,木暮 輝明: "泌尿器科疾患に対するマイクロ波を用いた治療法" 日本泌尿器科学会誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 熊崎 匠,木暮 輝明,他5名: "膀胱癌のマイクロ波凝固治療法における免疫パラメ-タの変動" 泌尿器科外. 2. 901-904 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 原田 忠,木暮 輝明,熊崎 匠,本郷 隆二,高 大輔,下田 次郎,佐藤 良延,吉田 公基: "実験的ウサギ移植膀胱腫瘍に対するマイクロ波凝固療法の基礎的検討" マイクロウェ-ブサシェリ-. 8. 7-12 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木暮 輝明,原田 忠,宮形 滋,熊崎 匠,本郷 隆二,高 大輔,下田 次郎,吉田 公基,佐藤 良延: "マイクロ波凝固療法を中心とした膀胱癌の治療成績" マイクロウェ-ブサ-ジェリ-. 8. 57-60 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Harada,T.,Kigure,T.,Kumazaki,T.,Etori,K.,Satoh,Y.and Tsuchida,S.: "Intraoperative realーtime ulfrasonic scanning for microwave coagulation of the prostate" Urol.Radiology. 12. 45-49 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tadashi Harada: "Intraoperative Real-time Ultrasonic Scanning for Microwave coagulation of the Prostate" Urologic Radiology.

    • Related Report
      1989 Annual Research Report
  • [Publications] Tadashi Harada: "Remote afterloading Transurethral Radiotherapy for prostatic Cancer" Urologia Internationalis. 45. 41-43 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 熊崎 匠: "膀胱癌のマイクロ波凝固療法における免疫バラメ-タの変動" 泌尿器外科. 2. 901-904 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 原田 忠: "実験的ウサギ移植膀胱腫瘍に対するマイクロ波凝固療法の基礎検討" マイクロサ-ジェリ-投稿予定.

    • Related Report
      1989 Annual Research Report
  • [Publications] 木暮輝明: "マイクロ波凝固療法を中心とした膀胱癌の治療成績" マイクロサ-ジェリ-.

    • Related Report
      1989 Annual Research Report
  • [Publications] 原田 忠: "膀胱癌に対する腔内照射およびマイクロ波凝固療法の治療効果" 癌治療学会誌.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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