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The Sensitivity Test for Human Urinary Tract Malignancies Making of use of the Chick Embryo Method using Chorioallantoic Membrane

Research Project

Project/Area Number 01570882
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKanazawa university

Principal Investigator

UCHIBAYASHI Tadao  Kanazawa University Department of Urology, 医学部・附属病院, 講師 (90151894)

Co-Investigator(Kenkyū-buntansha) UEKI Osamu  Kanazawa University Department of Urology, 医学部附属病院, 助手 (10223447)
西野 昭夫  金沢大学, 医学部附属病院(泌尿器科), 助手 (80198481)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsSensitivity test / Urinary tract malignancies / Chick embryo method / MTT method / Molecular biology / 温熱治療 / 感受性試験 / 特異的DNA増幅法
Research Abstract

In sensitivity tests of chemotherapy alone, hyperthermia alone, or a combination of the two against human urinary tract malignancies making use of the chick embryo method using chorioallantoic membrane, measurement of the weight of the tumor mass was considered to be an effective method of evaluating the antitumor effect. However, in cases in whicha a large part of the tumor is necrotic, this evaluation method did not provide reliable results. At present, using the the MTT method, more accurate quantitative results have been obtained. As a sensitivity test for metastatic tumors using continuously cultured cell lines, DNA is extracted from the metastatic organs of a fertilized chick embryo, specific DNA amplification and immuno-electro-phoresis are performed, and the DNA content is measured. By this method, it was shown that is possible to quantitatively evaluate the anti-tumor effect of various treatment methods.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 打林 忠雄,他: "鶏卵法による温熱と抗癌剤併用効果の検討" 日本泌尿器科学会雑誌. 80. 17-21 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 西野 昭夫,他: "進行性泌尿器悪性腫瘍の局所温熱療法におけるリンパ球サブセットの検討" 日本ハイパ-サ-ミア誌. 5. 27-36 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H.Yamamoto,et al.: "8MHz radiofrequency hyperthermia for pain relief on advanced urological cancer" Hyperthermic Oncology. 1. 134-135 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 中嶋 和喜,他: "浸潤性膀胱癌に対する8MHzーRF局所温熱療法の治療成績" 日本ハイパ-サ-ミア誌. 5. 181-185 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 李 秀雄,他: "電気分解式水素クリアランス法による腎腫瘍および周囲正常組織局所血流量の検討" 日本ハイパ-サ逝ア誌. 5. 375-379 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Uchibayashi,et al.: "Responses of tumor cell lines implanted onto the chorioallantoic membrane of chick embryo to anticancer agents in combination with hyperthermia" Urol.Res.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Amano et al: "A combined therapy of hyperthermia and tumor necrosis factor for nude mice bearing kkー47 bladder cancer" J.UroI.144. 370-374 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Uchibayashi et al.: "Responses of tumor cell lines and surgical specimens transplanted onto chorioallantoic membrane of chick embryo to anticancer agents in combination with/without hyperthermia" Jpn. J. Urol. 80. 17-21 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Nishino et al.: "A study of lymphocyte subsets in patients treated with regional hyperthermia for advanced urological malignancies" Jpn. J. Hyperthermic Oncol. 5. 27-36 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Yamamoto et al.: "8MHz radio frequency hyperthermia for pain relief on advanced urological cancer" Hyperthermic Oncoflogy. 1. 134-135 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Nakajima et al.: "A combined treatment of 8MHz radio-frequency hyperthermia, THP-adriamycin, CDDP or irradiation for invasive bladder carcinoma" Jpn. J. Hyperthermic oncol.5. 181-185 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Lee etal.: "A study of local blood flow in renal cancer and normal tissue using a hydrogen gas clearance method" Jpn. J. Hyperthermic Oncol.5. 375-379 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Amano et al.: "A combined therapy of hyperthermia and tumor necrosis factor for nude mice bearing KK-47 bladder cancer" J. Urol.144. 370-374 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Uchibayashi et al.: "Responses of tumor cell lines implanted onto the chorioallantoic membrane of chick embryo to anticancer agents in combination with hyperthermia" Urol. Res. 1991

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 打林 忠雄ほか: "鶏卵法による温熱と抗癌剤併用効果の検討" 日泌尿会誌. 80. 17-21 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yamamoto et al.: "Radiofregency Ryperthermia for pain relief on advanced urological cancer" Hyperthermic Oncology. 1. 134-135 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Uchibayashi et al.: "Responses of tumor cell lines implanted onto the chorioーallantoic membrane of chick embryo to anticancer agents in combination with hyperthermia" Urol.Res.Accepted.

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Amano et al.: "A combined therapy of hyperthermia and tumor necrosis factor for nude mice bearing KKー47 bladder cancer" J.Urol.144. 370-374 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Uchibayashi: "Responses of Tumor Cell Lines and Surgical Specimens Transplanted onto chorioallantoic Membrare of Chick Embryo to Anticancer Agents in Combination with/without Hyperthermia" Hyperthermic Oncology,'88,Taylor and Francis Publishing,Edited by Tsutomu Sugahara. 216-217 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Amano: "A Combined Therapy of Hyperthermia and Tumor Necrosis Factor for Nude Mice Bearing KK-47 Bladder Cancer" Hyperthermic Oncology, '88. Taylor and Francis Publishing,Edited by Tsutomu Sugahara. 541-542 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Hisazumi: "Eight MHZ RF-Hyperthermia for Deep-seated Urological Malignancies" Hyperthermic Oncology,'88.Taylor and Francis Publishing,Edited by Tsutomu Sugahara. 563-564 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 打林忠雄: "鶏卵法による温熱と抗癌剤併用効果の検討" 日本泌尿器科学会雑誌. 80. 17-21 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 西野昭夫: "進行性泌尿器悪性腫瘍の局所温熱療法におけるリンパ球サブセットの検討" 日本ハイパ-サ-ミア誌. 5. 27-36 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 中嶋和喜: "浸潤性膀胱癌に対する8MHz-RF局所温熱療法の治療成績" 日本ハイパ-サ-ミア誌. 5. 181-185 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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