| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Motoyuki Kochi Medical School, Urology, Assistant, 医学部, 助手 (50220348)
YAMASHITA Akemi Kochi Medical School, Urology, Assistant, 医学部, 助手 (70230414)
渡辺 裕修 高知医科大学, 医学部, 助手 (20201220)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
1) Although the average of NK activity of regional lymph nodes was 10%, cytotoxicity of LAK cells induced by interleukin-2 from lymph nodes was 20-30%. The cytotoxicity of LAK cells induced from one of them who had lymph node metastasis was the strongest at the condition of less than 20 units/ml of interleukin density and the culture time is from 3 till 5 days.
2) On the subsets of peripheral blood lymphocyte, the number of anti-Leu4(+), antiLeul9(+) cells was not correlated to stage, but decreased at terminal stage. As stage is higher, the cell number of anti-Leu2a(+), HLA-DR(+) was more than that of anti-Leu3a(+), HLA-DR(+) and anti-Leu2a(+) anti-Leul5(+) cells were more than anti-Leu2a(+), anti-Leul5(-) cells.
3) On the subsets of regional lymph node lymphocyte by ABC stain, anti-Leu3a(+) cells were more than. anti-Leu2a(+) cells. Since few anti-Leu7(+), anti-Leull(+) cells were there, its cytotoxicity may be little.
4) On the subsets of 1-lymphocyte around the tumor, anti-Leu7(+), anti-Leull(+) cells were rare and anti-Leu2a(+), anti-Leul5(-) cells were internal and anti-Leu3a(+) cells external.
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