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Pulmonary Hypoplasia and Morphological Characteristics and Surfactant Content Following Oligohydramnios or Diaphragmatic Hernia.

Research Project

Project/Area Number 01570913
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionAkita University

Principal Investigator

HIGUCHI Motokazu  Dept. of Obstet. Gynecol. Associate Prof., 医学部, 助教授 (20006779)

Co-Investigator(Kenkyū-buntansha) SAITO Masahiro  The First Dept. of Pathology, Lecture, 医学部, 助手 (70162229)
SAGESHIMA Naoto  The Second Dept. of Pathology, Lecture, 医学部, 講師 (10153967)
YOSHINO Hiroaki  The First Dept. of Surgery. Lecture, 医学部, 助手 (90182807)
KATO Tetsuo  The First Dept. of Surgery. Associate Professor, 医学部, 助教授 (20004963)
HIRANO Hideto  Dept. of Obstet. Gynecol. Lecture, 医学部, 講師 (80156687)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordspulmonary hypoplasia / oligohydramnios / diaphragmatic hernia / pulmonary surfactant / Fetus / oligohydramnios / Pulmonary hypoplasia / Pulmonary surfactant / pulmonary hypoplasia / Oligohydramnios / congenital diaphyragmatic hernia
Research Abstract

To study the effect of oligohydramnios on lung growth and biochemical lung development in fetal rabbits, amniotic fluid was drained through a tube inserted into the maternal peritoneal cavity on the 23rd day of gestation. 1-ittermate fetuses without an amniotic shunt were used as controls. The fetuses were delivered abdominally on the 28th day of gestation. In a total of 8 pregnant does, 17 fetuses underwent amniotic shunting and 22 fetuses were used as controls. The amniotic shunt produced a significant reduction in the amniotic fluid volume. There were no differences in the wet weights of the fetal body, liver or brain between the two groups. however, the amniotic sliurit significantly decreased the wet weight of the fetal lung, fetal lung wet weight/body weight ratio, and protein concentration per lung as compared to tile control fetuses. In the fetal liver and brain tissues, no changes were found in the concentrations, of total phospholipids, phosphatidylcholine (PC) or disaturated phosphatidylcholine (DSPC, the main component of Iiing surfactant) per g of wet tissue and per mg of protein. however, the lungs of the fetuses with amniotic shunts contained significantly more PC and DSPC, and the IIS ratio was higher tlian in the control fetuses. These results suggest that the oligoliydramnios produced by an amniotic silunt causes pulmonary hypoplasia, but raises the pulmonary surfactant content of fetal rabbit lung.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Motokazu Higuchi et al: "The influence of experimental pulmonary hypoplasia due to oligohydramnios on lung growth and pulmonary surfactant production in fetal rabbit" Journal of Japanese Medical Society for Interface. 21. 184-185 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Motokazu Higuchi et al: "The influence of experimentally produced oligohydramnios on lung growth and pulmonary surfactant content in fetal rabbit" Journal of Developmental Physiology. 16. 223-227 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] MOTOKAZU HIGUCHI ET AL.: "The Influence of Experimental Pulmonary Hypopiasia Due to Oligohydramnios on Lung Growth and Pulmonary Surfactant Production in Fetal Rabbit." J. of Japanese Medical Society for Biological Interface. 21. 184-185 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] MOTOKAZU HIGUCHI ET AL.: "The Influence of Experimentally Produced Oligohydramnjos on Lung Growth and Pulmonary Surfactant Content in Fetal Rabbit." J. of Developmental Physiology. 16. 223-227 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Motokazu Higuchi et al: "The influence of experimental pulmonary hypoplasia due to oligohydramnios on lung growth and pulmonary surfactant production in fetal rabbit" Journal of Japanese Medical Society for Interface. 21. 184-185 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Motokazu Higuchi et al: "The influence of experimentally produced oligohydramnios on lung growth and and pulmonary content in fetal rabbit" Journal of Developmental Physiology. 16. 223-227 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 加藤 哲夫、他: "先天性横隔膜ヘルニア肺の組織計測および三次元再構築による検討" 日本界面医学雑誌. 21. 118-121 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Higuchi et al.: "The influence of pulmonary hypoplasia following experimentally produced oligohydramnios on lung growth and pulmonary surfactant production in fetal rabbits" J.developmental phisiology.

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2018-02-02  

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