• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A new approach to the diagnosis of Endometrial Carcinoma - P-450HFLa and PP 4 -

Research Project

Project/Area Number 01570918
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Chiba

Principal Investigator

INABA Noriyuki  University of Chiba Faculty of Medicine, Assistant Prof, 医学部, 講師 (70114238)

Co-Investigator(Kenkyū-buntansha) OKAJIMA Yuko  University of Chida Faculty of Medicine, Instructor, 医学部, 助手 (10203978)
FUKAZAWA Ichio  University of Chiba Faculty of Medicine, Instructor, 医学部, 助手 (00189911)
IWSAKI Hideaki  University of Chiba Faculty of Medicine, Assistant Prof, 医学部, 講師 (60124244)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsEndometrial carcinoma / Oncodevelopmental antigen / Fetal protein / Placental protein / Tumor marker / 子宮体癌 / Oncodevelopmental antigen / Oncodelopmental antigen
Research Abstract

Immunohistochemical (ABC method) and immunoserological (EIA) investigations of P-450HFLa and PP4 demonstrated the followings during the period of 1989-1991.1.P-450HFLa
(1) This enzyme was age-dependent immunohistochemically in the human fetal livers, and clearly localized in the human placental villi. P-450HFLa was also localized in 86% of endometrial carcinomas.
(2) Its normal serum upper level was 3 u/ml (mean+2 sigma) . Serum values were not related to menstrual cycles, while the concentrations were elevated in 93% of late pregnancies.
(3) Although its pretherapeutic serum positive rates (>3u/ml) remained 10% in benign gynecologic diseases, the rates were 100% in endometrial carcinomas. 2.PP4
(1) PP4 was demonstrated immunohistochemically in human and cynomolgus placental villi and decidua. This protein was localized clearly in the endometrial stromal cells, while PP4 was demonstrated in 20% of endometrial cancers.
(2) Its normal serum upper limit was 10.9 ng/ml ( mean+2 sigma). Serum concentrations were elevated in the luteal phase and amniotic fluids, and lowered markedly in the late pregnancy.
(3) Its serum positive rates remained 18% in benign gynecologic diseases, but elevated up to 47% even in the 1st stage (FIGO) of endometrial carcinomas.
The above-mentioned data suggest a certain possibility that these two fetoplacental proteins could serve as a tumor marker for endometrial carcinoma.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 深沢 一雄,稲葉 憲之,他: "胎児・胎盤蛋白ーP450HFLaとPP4についてー" Oncology &Chemotuherapy. 5. 324-329 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鎌滝 哲也,稲葉 憲之,他: "新しい標的と抗癌剤耐性しチトクロムPー450" 癌と化学療法. 16. 605-610 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ota Y.Inaba N et al: "Enzym ummunoassay for placental protein 4(PP4) and its possible cliagnostic significance in patients with genital tract cancar" Arch Gynecal Obstet. 247. 139-147 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajima Y.Inada N.et al: "Immunohistochemical investigation of Pー450HFLa in human and Cynomolgusmonkey placentae" Areh Gynecal Pbstet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajima Y.Inaba N.et al: "Immunohistochemical Investigation of Pー450HFLa in gunecologic cliseases." Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajma Y.Inaba N,et al: "Serum levels of Pー450HFLa in gynecologic diseases" Arch Gynecal Obstet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fukasawa I, Inaba N, et al: "Fetoplacental proteins-P450HFLa and PP4-" Oncology & Chemotherapy. 5. 324-329 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kamataki T, Inaba N, et al: "New chemotherapeutic targets and resistance to chemotherapeutic agents - In relation to cytochrome P-450" Cancer and Chemotherapy. 16. 605-610 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] "Enzyme immunoassay for placental protein 4 (PP4) and its possible diagnostic significance in patients with genital tract cancer" Arch Gynecol Obstet. 247. 139-147 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajima Y, Inaba N, et al: "Immunohistochemical investigation of P-450HFLa in human and cynomolgus monkey placentae" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajima Y, Inaba N, et al: "Immunohistochemical investigation of P-450HFLa in gynecologic diseases" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okajima Y, Inaba N, et al :"Serum levels of P-450HFLa in gynecologic diseases" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ota Y,Inaba N,et al: "Enzyme immuno assay for placental tissue protein 4 (PP_4) and its possible diagnostic significance" Arch Gynecol Obstet. 247. 139-147 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鎌窪 哲也,稲葉 憲之 他: "新しい標的と抗癌剤耐性ー抗癌剤耐性とチトクロ-ムPー450" 癌と化学療法. 76. 605-610 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Okajima Y.Inaba N et al.: "Immunohisto chemical investigation of Pー450HFLa in human and cynomalgus monkey placentae" Arch Gynecol Obstet.

    • Related Report
      1990 Annual Research Report
  • [Publications] Okajima Y.Inaba N et al.: "Immunohisto chemical investigation of Pー450HFLa in gynecologic diseases." Arch Gynecol Obstet.

    • Related Report
      1990 Annual Research Report
  • [Publications] Okajima Y.Inaba N et al.: "Serum levels of Pー450HFLa in gynecologic diseases." Arch Gynecol Obstet.

    • Related Report
      1990 Annual Research Report
  • [Publications] 深沢一雄,稲葉憲之,太田順子,岡嶋祐子,高見澤裕吉: "胎児・胎盤蛋白-P450ーHFLaとPP_4について-" Oncology & Chemotherapy. 5. 324-329 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 稲葉憲之,深沢一雄,松本玲子: "産婦人科領域における腫瘍マ-カ-について" 産婦人科Up Date. 115-123 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ota Y,Inaba N,Shirotake S,Fukazawa I,Takamizawa H,Bohn H: "Enzyme immunoassay for placental tissue protein 4(PP_4)and its possible diagnostic significance." Arch Gynecol Obstet.

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi