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A study of coagulation and fibrinolysis abnormalities in preeclamptic patients.

Research Project

Project/Area Number 01570924
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KOBAYASHI Takao (1990-1991)  Hamamatsu Univ. Sch. of Med. Dept. of Obslel. & Assistant professor, 医学部, 助手 (30198452)

小林 隆夫 (1989)  浜松医科大学, 医学部, 講師 (20107808)

Co-Investigator(Kenkyū-buntansha) KANAYAMA Naohiro  Hamamatsu Univ. Sch. of Med. Dept. of Obslel. & Gynecol. Assistant, 医学部, 助手 (70204550)
SUMIMOTO Kazuhiro  Hamamatsu Univ. Sch. of Med. Dept. of Obslel. & Gynecol. Assistant, 医学部, 助手 (30126817)
NISHIGUCHI Tomizou  Hamamatsu Univ. Sch. of Med. Dept. of Obsl. & Gynecol. Assistant (30198452)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordspreeclampsia / chronic DIC / AT III / alpha_2 antiplasmin-plasmin complex (PIC) / D-Dimer FDP / Clinical Index / Coagulation Index / anticoagulant therapy / α_2ーAntiplasminーPlasmin complex / DーDimer FDP / Gestosis Index(GI) / ATIII療法 / AT III / α_2ーantiplasminーplasmin complex(PIC) / Dーdimer FDP / Canonical correlation analysis / edema / proteinuria / Protein C activation peptide(PCP) / D-Dimer FDP / Throbin-ATIII complex(TAT) / α_2-Antiplasmin-Plasmin complex(PIC) / Protein S / APC-α_1AT coplex / Plasminogen activator inhibitor 1(PAI-1) / Plasminogen activator inhibitor 2(PAI2)
Research Abstract

1. The hypercoagulable state in preeclamptic patients was investigated in comparison with normal pregnant women using new coagulation parameters : AT III, alpha_1 AT, Protein C, Protein C inhibitor(PCI), APC-PCL complex, AI)C- alpha_1 AT complex, Protein S, alpha_2 antiplasmin-plasmin complex(PIC), Thrombin-ATUI complex(TAT), uPA, tPA, PAI-1, PAI-2, Protein C activation peptide(PCP)and D-Dimer FDP. Among these parameters, a significant increase in TAT, PIC, D-Dimer FDP and APC-alpha_1 AT complex was observed, and a decrease in AT]Hantigen was observed in preeclampsia in comparison with normal pregnant-women. This prove hypercoagulabilities in preeclampsia, which might be one of the coagulalioti disorders such as chronic DIC.
2. The relationship between clinical symptoms and coagulation abnormalities of preeclampsia was analyzed using of canonical correlation analysis as a multivariate analysis. The indicies obtained from the results, which were called the Clinical Index and the Coagulation Index, had significantly high correlation coefficient r=0.7006 on selected varieties : edema, proteinuria and systolic blood pressure among clinical symptoms and AT III antigen, PIC and D-Dimer FDP among coagulative parameters. These new indicies were considered to be useful to evaluate the clinical severity of preeclampsia and to evaluate the efficacy of treatment.
3. Finally the results of present study suggest the possibility of anticoagulants, fibrinolytic agents and platelet aggregation inhibitors on treatment of preeclampsia. Recently we observed therapeutic effectiveness of AT III concentrate as anlicoagulant therapy to severe preeclampsia. As a result, we obtained clinical efficacy of this treatment because of correction of the hypercoagulable state and improvement of clinical symptoms and the fetal condition.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Toshihiko Terao et al: "Pathological State of the Coagulatory and Fibrinolytic System in Preeclampsia and the Possibility of Its Treatment with ATIII Concentrate" Asia-Oceania J.Obstet,Gynaecol. 15. 25-32 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小林 隆夫他: "産科DICにおける新しい凝固線溶系分子マ-カ-の変動について" 東海プラスミン研究会誌(29ー30回). 24-30 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 中島 彰他: "正常妊娠及び妊娠中毒症における血中 _tPa,PAIー1及びPAIー2の推移" 東海血栓症セミナ-報告集(31ー32回). 26-28 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Francisco Espana et al: "Complexes of activated protein C with α_1-antitrypsin in normal pregnancy and in severs preeclampsia" Am.J.Obstet,Gynecol. 164. 1310-1316 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Toshihiko Terao et al: "The Relationship between clinical Signs and Hypercoagulable State in Toxemia Pregnancy" Gynecologic and Obstetric Investigation. 31. 74-85 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小林 隆夫他: "Protein C周辺蛋白の変動よりみた妊娠時の過凝固状態に関する検討" 産婦人科・新生児血液. 2. 63-71 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T., et al.: "Protein C inhibitor and its complexes in normal pregnant and preeclamptic pregnant plasma" Thromb. Haemostas. 62. 302 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Terao T., et al: "Pathological State of the Coagulatory and Fibrinolytic System in Preeclampsia and the Possibility of Its Treatment with AT III Concentrate" Asia-Oceania J. Obstet. Gynaecol. 15. 25-32 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T., et al.: "Analysis of hypercoagulable state in normal pregnant" Acta. Obst. Gynaec. Jpn. suppl. 42. 378 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakajima A., et al.: "Analysis of plasma PAI-1 and PAI-2 in normal pregnant and preeclamptic patients" Acta. Obst. Gynaec. Jpn. suppl. 42. 379 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T., et al.: "Analysis of coagulation/fibrinolysis abnormalities in preeclamptic patient" Protease Inhibitors. Elsevier science publishers B. V.177-186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Franisco Espana, et al.: "Complexes of activated protein C with alph_1 -antitrypsin normal pregnancy and in severe preeclampsia" Am J Obstet Gynecol. 164. 1310-1316 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Terao T., et al.: "The Relationship between Clinical Signs and Hypercoagulable State in Toxemia of Pregnancy" Gynecologic and Obstegtric Investigation. 31. 74-85 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kobayashi T., et al.: "Protein C pathway and the hypercoagulabilitity during pregnancy" Jpn J Obstet Gynecol Neonatal Hematol. 2. 63-71 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小林 隆夫,他: "妊娠時におけるProtein C周辺蛋白の変動" 日本産婦人科新生児学会誌. 2. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小林 隆夫: "正常妊娠および異常妊娠時における凝固線溶動態" 東海血栓セミナ-報告集(第31回,第32回).

    • Related Report
      1990 Annual Research Report
  • [Publications] TAKAO KOBAYASHI: "ANALYSIS OF COAGULATION/FIBRINOLYSIS ABNORMALITIES IN PREECLAMPTIC PATIENTS" Protease Inhibitors.Elsevier Science Publishers B.V.177-186 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 寺尾俊彦: "Protein C activation peptideの測定とその意義" 東海プラスミン研究会誌(第27回〜28回). 28. 46-50 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takao Kobayashi: "Protein C inhibitor and its complexes in normal pregnant and preeclamptic pregnant plasma" Thromb Haemostas. 62. 302 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 小林隆夫: "妊娠時の過凝固状態に関する検討" 日産婦誌(臨時増刊). 42. 378 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 中島彰: "正常妊娠及び妊娠中毒症におけるPAI1及びPAI2の推移" 日産婦誌(臨時増刊). 42. 379 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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