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Gene expression of Vit D conversion eyzymes and Ca metaboism in the feto-placental system

Research Project

Project/Area Number 01570934
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionFaculty of Medicine, University of Tokyo (1990-1991)
Kagawa Medical School (1989)

Principal Investigator

FUKUOKA Hideoki  University of Tokyo, Faculty of Medicine, Associate Professor, 医学部(医), 助教授 (80111540)

Co-Investigator(Kenkyū-buntansha) TANAKA Hirokazu  Kagawa Medical University. Lecturer, 母子科学, 助手 (80207125)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsCalcium metabolism / Feto-placental unit / 1-alpha-hydroxylase / 25-hydroxyvitamin D 24R-hydroxylase / Vitamin D conversion enzyme / Vitamin D / 活性型ビタミンD / ビタミンD転換酵素 / 胎盤IUGR(子宮内胎児発育不良)
Research Abstract

Calcium metabolism is one of the most interesting areas in the endocrinology. Much amount of research have been done to clarify it in the molecular levels. However, the regulating mechanisms in the feto-placental systems are to be clarified. In addition, the mechanism of gene expression of Vit D conversion enzymes in the fetus is a little different from the adult organs. So our research project consisted with (1) studying chronologically the enzymatic characterization of 1-alpha-hydroxylase and 24R-hydroxylase in the mitochondria in the human placenta, (2) analyzing the 1-alpha-hydroxylase and 24R-hydroxylase in the fetal brain, lung, kidney, which has been thought to be exist only in the renal tubules.
We have found that the biologically active vitamin D was synthesized in the placenta and is one of the important substances regulating the fetal growth. The activity of 24R-hydroxylase appears around pregnancy 20 weeks and slightly increases until partrition. In the placenta of severe type of IUGR (intrauterine growth retardation), however, only 24R-hydroxylase except 1-alpha-hydroxylase was found. We suspect that the gene expression of this enzyme might be inhibited. The activity of rabbit fetus and neonate, and that of 1-alpha-hydroxylase was also found in the brain, placenta, kidney. In the brain it increased transiently and disappeared after the age of the neonate. These new finding suspects that the vitamin D conversion enzyme system might consist with the two types of the adult and the fetus, appearing transiently. We are trying to characterize these fetal systems, especially of 1-alpha-hydroxylase.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] H.Fukuoka,R.Hamamoto,M.Higurashi: "Heterogeneity of serum and amniotic fluid prolactin in humans" Horm Res. 35. 58-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Fukuoka,J.Ohnish,Y.Nishii M.Makoto,Y.Ichikawa.: "Cytochrome P-450-linked monooxygenase systems of bovine brain motochondria and microsomes." Int.J.Biochemistry. 22. 1139-1145 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 福岡 秀興,山城 千珠,神保 利春: "SLE合併妊娠" 産と婦. 57. 215-219 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 福岡 秀興 その他: "抗テンカン剤服用妊娠における胎盤性ビタミンD転換酵素活性の生化学的分析" 母性衛生. 31. 569-570 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 福岡 秀興,神保 利春: "ペプチドホルモン前駆体遺伝子の構造,発現調節と前駆体のプロセッシングー性腺刺激ホルモン(LH,FSH)ー" 日本臨床. 47. 2204-2212 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 福岡 秀興,神保 利春: "周生期における血清Osteocarcinの代謝動態" 日本内分泌学会雑誌. 65. 1116-1122 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Fukuoka,Y.Kobayashi and T.Jimbo: "Immunochemical and bioche mical study of HCG-like protein in the pituitary of postmenopausal women,in "Placental protein hoemones edt by M.Mochizuki and R.Hussa"" Excepta Medica, 335 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 福岡 秀興(分担): "妊娠におけるカルシウム代謝 ブリンシパル産科婦人科学産科編 坂元 正一,水野 正彦監修" メジカルビュ-社,東京., 891 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, R. Hamamoto, M. Higurashi: "Heterogeneity of serum and amniotic fluid prolactin in humans." Horm Res. 35. 58-63 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, J. Ohnishi, Y. Nishii, M. Nakano, Y. Ichikawa: "Cytochrome P-450-linked monooxygenase systems of bovine brain mitochondria and microsomes." Int. J. Biochem.22. 1139-1145 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, C. Yamashiro, T. Jimbo: "Care of the pregnancy with SLE." Obstet Gynecol. 57. 215-219 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, I. Kobayashi et al.: "Biochemical characterization of placental vitamin D conversion enzymes in the placenta of epileptic mother treated with of anticonvulsant." Jpn J Maternal Health. 31. 569-570 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, T. Jimbo: "Gene expression and processing of peptide hormones -LH and FSH-" Jpn J Clin Med. 47. 2204-2212 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Fukuoka, T. Jimbo: "Dynamic change of serum osteocalcin levels in the perinatal periods." Folia Endocrinol.65. 116-1122 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Fukuoka,R.Hamamoto,,M.Higurashi: "Heterogeneity of serum and amniotic fluid prolactin in humans" Horm Res. 35. 58-63 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Fukuoka,J.Ohnish,Y.Nishii,M.Makoto,Y.Ichikawa: "Cytochrome Pー450ーlinked monooxygenase systems of bovine brain motochondria and microsomes." Int.J.Biochemistry. 22. 1139-1145 (199-)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福岡 秀興,山城 千珠,神保 利春: "SLE合併妊娠" 産と婦. 57. 215-219 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福岡 秀興,その他: "抗テンカン剤服用妊娠における胎盤性ビタミンD転換酵素活性の生化学的分析" 母性衛生. 31. 569-570 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福岡 秀興,神保 利春: "ペプチドホルモン前駆体遺伝子の構造,発現調節と前駆体のプロセッシングー性腺刺激ホルモン(LH,FSH)ー" 日本臨床. 47. 2204-2212 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福岡 秀興,神保 利春: "周生期における血清Osteocarcinの代謝動態" 日本内分泌学会雑誌. 65. 1116-1122 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Mochizuki and R.Hussa(ed.),H.Fukuoka,Y.Kobayashi and T.Jimbo: "Placental protein hoemones (Immunochemical and biochemical study of hCGーlike protein in the pituitary of postmenopausa women)" Excepta Media, 335 (1988)

    • Related Report
      1991 Annual Research Report
  • [Publications] 坂元正一,水野 正彦監修,福岡 秀興(分担): "妊娠におけるカルシウム代謝 ブリンシパル産科婦人科学 産科編" メジカルビュ-社,東京., 891 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福岡 秀興,山城 千珠,神保 利春.: "SLE合併妊娠" 産と婦,. 57. 215-219 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Fukuoka,J.Ohnishi,Y.Nishii,M.Nakano,Y.ichikawa;: "Cytochrome Pー450ーlinked monooxygenase systems of bovine brain mitochondria and microsomes.〕" Int.J.Biochemistry,. 22. 1139-1145 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Fukuoka,R.Hamamoto,M.Higurashi;: "Microheterogeneity of human prolactin in the circualtion and in the amniotic fluid." in Hormon Research in press.

    • Related Report
      1990 Annual Research Report
  • [Publications] 福岡 秀興,その他: "抗テンカン剤服用妊婦における胎盤性ビタミンD転換酵素活性の生化学的分析" 母性衛生. 31. 569-570 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 福岡 秀興,神保 利春: "ペプチドホルモン前駆体遺伝子の構造,発現調節と前駆体のプロセッシングー性腺刺激ホルモン(LH,FSH)ー" 日本臨床,. 47. 2204-2212 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 福岡 秀興,神保 利春: "周生期における血清Osteocartinの代謝動態," 日本内分泌学会雑誌. 65. 1116-1122 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Fukuoka,Y.Kobayashi,and T.Jimbo;: "Immunochemical and biochemical study of hCGーlike protein in the pituitary of postmenopausal women.in "Placental protein hormones ed by M.Mochizuki and R.Hussa"" Excepta Medica,335 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] 福岡 秀興,(分担執筆): "妊娠における無機質代謝,胎盤蛋白ホルモンーhCGープリンシパル産科学婦人科学 産科編 監修坂元正一,水野正彦" メジカルビュ-社,東京,

    • Related Report
      1990 Annual Research Report
  • [Publications] 福岡秀興,小林康浩,神保利春: "周生期に於けるオステオカルチンの代謝動態" 日本内分泌学会雑誌日内誌. 56. 756-768 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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